WFRF:(van der Velden J)
Sökning: WFRF:(van der Velden J) > Association of MC1R...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05822naa a2200829 4500 | |
| 001 | oai:lup.lub.lu.se:deaf5359-5cb1-41ce-8d97-f44575131a30 | |
| 003 | SwePub | |
| 008 | 160404s2010 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:121528150 | |
| 024 | 7 | a https://lup.lub.lu.se/record/16876882 URI |
| 024 | 7 | a https://doi.org/10.1093/jnci/djq3632 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1215281502 URI |
| 040 | a (SwePub)lud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Demenais, F4 aut |
| 245 | 1 0 | a Association of MC1R Variants and Host Phenotypes With Melanoma Risk in CDKN2A Mutation Carriers: A GenoMEL Study. |
| 264 | c 2010-10-20 | |
| 264 | 1 | b Oxford University Press (OUP),c 2010 |
| 520 | a Background Carrying the cyclin-dependent kinase inhibitor 2A (CDKN2A) germline mutations is associated with a high risk for melanoma. Penetrance of CDKN2A mutations is modified by pigmentation characteristics, nevus phenotypes, and some variants of the melanocortin-1 receptor gene (MC1R), which is known to have a role in the pigmentation process. However, investigation of the associations of both MC1R variants and host phenotypes with melanoma risk has been limited. Methods We included 815 CDKN2A mutation carriers (473 affected, and 342 unaffected, with melanoma) from 186 families from 15 centers in Europe, North America, and Australia who participated in the Melanoma Genetics Consortium. In this family-based study, we assessed the associations of the four most frequent MC1R variants (V60L, V92M, R151C, and R160W) and the number of variants (1, ≥2 variants), alone or jointly with the host phenotypes (hair color, propensity to sunburn, and number of nevi), with melanoma risk in CDKN2A mutation carriers. These associations were estimated and tested using generalized estimating equations. All statistical tests were two-sided. Results Carrying any one of the four most frequent MC1R variants (V60L, V92M, R151C, R160W) in CDKN2A mutation carriers was associated with a statistically significantly increased risk for melanoma across all continents (1.24 × 10(-6) ≤ P ≤ .0007). A consistent pattern of increase in melanoma risk was also associated with increase in number of MC1R variants. The risk of melanoma associated with at least two MC1R variants was 2.6-fold higher than the risk associated with only one variant (odds ratio = 5.83 [95% confidence interval = 3.60 to 9.46] vs 2.25 [95% confidence interval = 1.44 to 3.52]; P(trend) = 1.86 × 10(-8)). The joint analysis of MC1R variants and host phenotypes showed statistically significant associations of melanoma risk, together with MC1R variants (.0001 ≤ P ≤ .04), hair color (.006 ≤ P ≤ .06), and number of nevi (6.9 × 10(-6) ≤ P ≤ .02). Conclusion Results show that MC1R variants, hair color, and number of nevi were jointly associated with melanoma risk in CDKN2A mutation carriers. This joint association may have important consequences for risk assessments in familial settings. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 700 | 1 | a Mohamdi, H4 aut |
| 700 | 1 | a Chaudru, V4 aut |
| 700 | 1 | a Goldstein, A M4 aut |
| 700 | 1 | a Newton Bishop, J A4 aut |
| 700 | 1 | a Bishop, D T4 aut |
| 700 | 1 | a Kanetsky, P A4 aut |
| 700 | 1 | a Hayward, N K4 aut |
| 700 | 1 | a Gillanders, E4 aut |
| 700 | 1 | a Elder, D E4 aut |
| 700 | 1 | a Avril, M F4 aut |
| 700 | 1 | a Azizi, E4 aut |
| 700 | 1 | a van Belle, P4 aut |
| 700 | 1 | a Bergman, W4 aut |
| 700 | 1 | a Bianchi-Scarrà, G4 aut |
| 700 | 1 | a Bressac-de Paillerets, B4 aut |
| 700 | 1 | a Calista, D4 aut |
| 700 | 1 | a Carrera, C4 aut |
| 700 | 1 | a Hansson, Ju Karolinska Institutet4 aut |
| 700 | 1 | a Harland, M4 aut |
| 700 | 1 | a Hogg, D4 aut |
| 700 | 1 | a Höiom, Vu Karolinska Institutet4 aut |
| 700 | 1 | a Holland, E A4 aut |
| 700 | 1 | a Ingvar, Christianu Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)kir-cin |
| 700 | 1 | a Landi, MT4 aut |
| 700 | 1 | a Lang, J M4 aut |
| 700 | 1 | a Mackie, R M4 aut |
| 700 | 1 | a Mann, G J4 aut |
| 700 | 1 | a Ming, M E4 aut |
| 700 | 1 | a Njauw, C J4 aut |
| 700 | 1 | a Olsson, Håkanu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-hol |
| 700 | 1 | a Palmer, J4 aut |
| 700 | 1 | a Pastorino, L4 aut |
| 700 | 1 | a Puig, S4 aut |
| 700 | 1 | a Randerson-Moor, J4 aut |
| 700 | 1 | a Stark, M4 aut |
| 700 | 1 | a Tsao, H4 aut |
| 700 | 1 | a Tucker, M A4 aut |
| 700 | 1 | a van der Velden, P4 aut |
| 700 | 1 | a Yang, X R4 aut |
| 700 | 1 | a Gruis, N4 aut |
| 710 | 2 | a Karolinska Institutetb Kirurgi, Lund4 org |
| 773 | 0 | t Journal of the National Cancer Instituted : Oxford University Press (OUP)g 102, s. 1568-1583q 102<1568-1583x 1460-2105x 0027-8874 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/20876876?dopt=Abstracty FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1093/jnci/djq363y FULLTEXT |
| 856 | 4 | u https://academic.oup.com/jnci/article-pdf/102/20/1568/18614448/djq363.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1687688 |
| 856 | 4 8 | u https://doi.org/10.1093/jnci/djq363 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:121528150 |
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