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Development and val...
Development and validation of circulating CA125 prediction models in postmenopausal women
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- Sasamoto, Naoko (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Babic, Ana (författare)
- Dana-Farber Cancer Institute
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- Rosner, Bernard A. (författare)
- Harvard Medical School,Brigham and Women's Hospital / Harvard Medical School
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- Fortner, Renee T. (författare)
- German Cancer Research Centre
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- Vitonis, Allison F. (författare)
- Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School
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- Yamamoto, Hidemi (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Fichorova, Raina N. (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Titus, Linda J. (författare)
- Dartmouth College,Norris Cotton Cancer Center
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- Tjonneland, Anne (författare)
- Danish Cancer Society,University of Copenhagen
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- Hansen, Louise (författare)
- Danish Cancer Society
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- Kvaskoff, Marina (författare)
- Institut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP)
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- Fournier, Agnes (författare)
- Institut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP)
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- Mancini, Francesca Romana (författare)
- Institut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP)
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- Boeing, Heiner (författare)
- German Institute of Human Nutrition
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- Trichopoulou, Antonia (författare)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
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- Peppa, Eleni (författare)
- Hellenic Health Foundation, Athens
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- Karakatsani, Anna (författare)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
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- Palli, Domenico (författare)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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- Grioni, Sara (författare)
- Istituto Nazionale dei Tumori
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- Mattiello, Amalia (författare)
- University of Naples Federico II
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- Tumino, Rosario (författare)
- Civic and M.P Arezzo Hospital
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- Fiano, Valentina (författare)
- University of Turin
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- Onland-Moret, N. Charlotte (författare)
- University Medical Center Utrecht,Utrecht University
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- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer, World Health Organization
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- Gram, Inger T. (författare)
- UiT The Arctic University of Norway, Tromsø
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- Quiros, J. Ramon (författare)
- Public Health Directorate
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- Lujan-Barroso, Leila (författare)
- Catalan Institute of Oncology,Bellvitge University Hospital-IDIBELL
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- Sanchez, Maria-Jose (författare)
- Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP),University of Granada
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- Colorado-Yohar, Sandra (författare)
- University of Antioquia,CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council
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- Barricarte, Aurelio (författare)
- CIBER Epidemiology and Public Health (CIBERESP)
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- Amiano, Pilar (författare)
- CIBER Epidemiology and Public Health (CIBERESP)
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- Idahl, Annika, 1965- (författare)
- Umeå University,Umeå universitet,Obstetrik och gynekologi
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- Lundin, Eva (författare)
- Umeå University,Umeå universitet,Patologi
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- Sartor, Hanna (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups,Skåne University Hospital
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- Khaw, Kay-Tee (författare)
- University of Cambridge
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- Key, Timothy J. (författare)
- University of Oxford
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- Muller, David (författare)
- Imperial College London
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- Riboli, Elio (författare)
- Imperial College London
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- Gunter, Marc (författare)
- International Agency for Research on Cancer, World Health Organization
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- Dossus, Laure (författare)
- International Agency for Research on Cancer, World Health Organization
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- Trabert, Britton (författare)
- National Cancer Institute, USA
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- Wentzensen, Nicolas (författare)
- National Cancer Institute, USA
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- Kaaks, Rudolf (författare)
- German Cancer Research Centre
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- Cramer, Daniel W. (författare)
- Harvard Medical School,Brigham and Women's Hospital / Harvard Medical School
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- Tworoger, Shelley S. (författare)
- Harvard University,H. Lee Moffitt Cancer Center & Research Institute
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- Terry, Kathryn L. (författare)
- Brigham and Women's Hospital / Harvard Medical School,Harvard University
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(creator_code:org_t)
- 2019-11-26
- 2019
- Engelska.
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Ingår i: Journal of Ovarian Research. - : BioMed Central (BMC). - 1757-2215. ; 12:1
- Relaterad länk:
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https://doi.org/10.1...
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visa fler...
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https://umu.diva-por... (primary) (Raw object)
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https://ovarianresea...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background: Cancer Antigen 125 (CA125) is currently the best available ovarian cancer screening biomarker. However, CA125 has been limited by low sensitivity and specificity in part due to normal variation between individuals. Personal characteristics that influence CA125 could be used to improve its performance as screening biomarker.Methods: We developed and validated linear and dichotomous (>= 35 U/mL) circulating CA125 prediction models in postmenopausal women without ovarian cancer who participated in one of five large population-based studies: Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO, n = 26,981), European Prospective Investigation into Cancer and Nutrition (EPIC, n = 861), the Nurses' Health Studies (NHS/NHSII, n = 81), and the New England Case Control Study (NEC, n = 923). The prediction models were developed using stepwise regression in PLCO and validated in EPIC, NHS/NHSII and NEC. Result The linear CA125 prediction model, which included age, race, body mass index (BMI), smoking status and duration, parity, hysterectomy, age at menopause, and duration of hormone therapy (HT), explained 5% of the total variance of CA125. The correlation between measured and predicted CA125 was comparable in PLCO testing dataset (r = 0.18) and external validation datasets (r = 0.14). The dichotomous CA125 prediction model included age, race, BMI, smoking status and duration, hysterectomy, time since menopause, and duration of HT with AUC of 0.64 in PLCO and 0.80 in validation dataset.Conclusions: The linear prediction model explained a small portion of the total variability of CA125, suggesting the need to identify novel predictors of CA125. The dichotomous prediction model showed moderate discriminatory performance which validated well in independent dataset. Our dichotomous model could be valuable in identifying healthy women who may have elevated CA125 levels, which may contribute to reducing false positive tests using CA125 as screening biomarker.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Ovarian cancer
- Early detection
- CA125
- Prediction model
- Postmenopausal
- CA125
- Early detection
- Ovarian cancer
- Postmenopausal
- Prediction model
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Sasamoto, Naoko
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Babic, Ana
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Rosner, Bernard ...
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Fortner, Renee T ...
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Vitonis, Allison ...
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Yamamoto, Hidemi
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visa fler...
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Fichorova, Raina ...
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Titus, Linda J.
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Tjonneland, Anne
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Hansen, Louise
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Kvaskoff, Marina
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Fournier, Agnes
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Mancini, Frances ...
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Boeing, Heiner
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Trichopoulou, An ...
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Peppa, Eleni
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Karakatsani, Ann ...
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Palli, Domenico
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Grioni, Sara
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Mattiello, Amali ...
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Tumino, Rosario
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Fiano, Valentina
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Onland-Moret, N. ...
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Weiderpass, Elis ...
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Gram, Inger T.
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Quiros, J. Ramon
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Lujan-Barroso, L ...
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Sanchez, Maria-J ...
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Colorado-Yohar, ...
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Barricarte, Aure ...
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Amiano, Pilar
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Idahl, Annika, 1 ...
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Lundin, Eva
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Sartor, Hanna
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Khaw, Kay-Tee
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Key, Timothy J.
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Muller, David
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Riboli, Elio
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Gunter, Marc
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Dossus, Laure
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Trabert, Britton
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Wentzensen, Nico ...
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Kaaks, Rudolf
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Cramer, Daniel W ...
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Tworoger, Shelle ...
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Terry, Kathryn L ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reproduktionsmed ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Journal of Ovari ...
- Av lärosätet
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Umeå universitet
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Lunds universitet