((WFRF:(Kaaks R)) mspu:(article) pers:(Tjonneland A)) srt2:(2005-2009)
Sökning: ((WFRF:(Kaaks R)) mspu:(article) pers:(Tjonneland A)) srt2:(2005-2009) > Haplotype analysis ...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04478naa a2200745 4500 | |
| 001 | oai:lup.lub.lu.se:6687a936-68ea-4eae-8247-267764a7eea3 | |
| 003 | SwePub | |
| 008 | 160401s2006 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/4175562 URI |
| 024 | 7 | a https://doi.org/10.1158/0008-5472.CAN-05-35742 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Feigelson, HS4 aut |
| 245 | 1 0 | a Haplotype analysis of the HSD17B1 gene and risk of breast cancer: A comprehensive approach to multicenter analyses of prospective cohort studies |
| 264 | 1 | c 2006 |
| 520 | a The 17 beta-hydroxysteroid dehydrogenase 1 gene (HSD17B1) encodes 17HSD1, which catalyzes the final step of estradiol biosynthesis. Despite the important role of HSD17B1 in hormone metabolism, few epidemiologic studies of HSD17B1 and breast cancer have been conducted. This study includes 5,370 breast cancer cases and 7,480 matched controls from five large cohorts in the Breast and Prostate Cancer Cohort Consortium. We characterized variation in HSD17B1 by resequencing and dense genotyping a multiethnic sample and identified haplotype-tagging single nucleotide polymorphisms (htSNP) that capture common variation within a 33.3-kb region around HSD17B1. Four htSNPs, including the previously studied SNP rs605059 (S312G), were genotyped to tag five common haplotypes in all cases and controls. Conditional logistic regression was used to estimate odds ratios (OR) for disease. We found no evidence of association between common HSD17B1 haplotypes or htSNPs and overall risk of breast cancer. The OR for each haplotype relative to the most common haplotype ranged from 0.98 to 1.07 (omnibus test for association: X-2 = 3.77, P = 0.58, 5 degrees of freedom). When cases were subdivided by estrogen receptor (ER) status, two common haplotypes were associated with ER-negative tumors (test for trend, Ps = 0.0009 and 0.0076; n = 353 cases). HSD17B1 variants that are common in Caucasians are not associated with overall risk of breast cancer; however, there was an association among the subset of ER-negative tumors. Although the probability that these ER-negative findings are false-positive results is high, these findings were consistent across each cohort examined and warrant further study. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng |
| 700 | 1 | a Cox, DG4 aut |
| 700 | 1 | a Cann, HM4 aut |
| 700 | 1 | a Wacholder, S4 aut |
| 700 | 1 | a Kaaks, R4 aut |
| 700 | 1 | a Henderson, BE4 aut |
| 700 | 1 | a Albanes, D4 aut |
| 700 | 1 | a Altshuler, D4 aut |
| 700 | 1 | a Berglund, Göranu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-gbe |
| 700 | 1 | a Berrino, F4 aut |
| 700 | 1 | a Bingham, S4 aut |
| 700 | 1 | a Buring, JE4 aut |
| 700 | 1 | a Burtt, NP4 aut |
| 700 | 1 | a Calle, EE4 aut |
| 700 | 1 | a Chanock, SJ4 aut |
| 700 | 1 | a Clavel-Chapelon, F4 aut |
| 700 | 1 | a Colditz, G4 aut |
| 700 | 1 | a Diver, WR4 aut |
| 700 | 1 | a Freedman, ML4 aut |
| 700 | 1 | a Haiman, CA4 aut |
| 700 | 1 | a Hankinson, SE4 aut |
| 700 | 1 | a Hayes, RB4 aut |
| 700 | 1 | a Hirschhorn, JN4 aut |
| 700 | 1 | a Hunter, D4 aut |
| 700 | 1 | a Kolonel, LN4 aut |
| 700 | 1 | a Kraft, P4 aut |
| 700 | 1 | a LeMarchand, L4 aut |
| 700 | 1 | a Linseisen, J4 aut |
| 700 | 1 | a Modi, W4 aut |
| 700 | 1 | a Navarro, C4 aut |
| 700 | 1 | a Peeters, PH4 aut |
| 700 | 1 | a Pike, MC4 aut |
| 700 | 1 | a Riboli, E4 aut |
| 700 | 1 | a Setiawan, VW4 aut |
| 700 | 1 | a Stram, DO4 aut |
| 700 | 1 | a Thomas, G4 aut |
| 700 | 1 | a Thun, MJ4 aut |
| 700 | 1 | a Tjonneland, A4 aut |
| 700 | 1 | a Trichopoulos, D4 aut |
| 710 | 2 | a Internmedicin - epidemiologib Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Cancer Researchg 66:4, s. 2468-2475q 66:4<2468-2475x 1538-7445 |
| 856 | 4 | u http://cancerres.aacrjournals.org/cgi/content/abstract/66/4/2468x freey FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1158/0008-5472.CAN-05-3574y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/417556 |
| 856 | 4 8 | u https://doi.org/10.1158/0008-5472.CAN-05-3574 |
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- Feigelson, HS
- Cox, DG
- Cann, HM
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- Kaaks, R
- Henderson, BE
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- Albanes, D
- Altshuler, D
- Berglund, Göran
- Berrino, F
- Bingham, S
- Buring, JE
- Burtt, NP
- Calle, EE
- Chanock, SJ
- Clavel-Chapelon, ...
- Colditz, G
- Diver, WR
- Freedman, ML
- Haiman, CA
- Hankinson, SE
- Hayes, RB
- Hirschhorn, JN
- Hunter, D
- Kolonel, LN
- Kraft, P
- LeMarchand, L
- Linseisen, J
- Modi, W
- Navarro, C
- Peeters, PH
- Pike, MC
- Riboli, E
- Setiawan, VW
- Stram, DO
- Thomas, G
- Thun, MJ
- Tjonneland, A
- Trichopoulos, D
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