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Immunogenetics of l...
Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder.
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Herrera-Rivero, Marisol (author)
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Gutiérrez-Fragoso, Karina (author)
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Thalamuthu, Anbupalam (author)
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Amare, Azmeraw T (author)
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Adli, Mazda (author)
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Akiyama, Kazufumi (author)
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Akula, Nirmala (author)
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Ardau, Raffaella (author)
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Arias, Bárbara (author)
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Aubry, Jean-Michel (author)
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- Backlund, Lena (author)
- Karolinska Institutet
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Bellivier, Frank (author)
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Benabarre, Antonio (author)
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Bengesser, Susanne (author)
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Abesh, Bhattacharjee (author)
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Biernacka, Joanna (author)
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Birner, Armin (author)
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Cearns, Micah (author)
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Cervantes, Pablo (author)
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Chen, Hsi-Chung (author)
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- Chillotti, Caterina (author)
- Karolinska Institutet
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Cichon, Sven (author)
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Clark, Scott (author)
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Colom, Francesc (author)
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Cruceanu, Cristiana (author)
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Czerski, Piotr (author)
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Dalkner, Nina (author)
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Degenhardt, Franziska (author)
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Del Zompo, Maria (author)
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DePaulo, J Raymond (author)
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Etain, Bruno (author)
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Falkai, Peter (author)
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Ferensztajn-Rochowiak, Ewa (author)
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Forstner, Andreas J (author)
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Frank, Josef (author)
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- Frisen, Louise (author)
- Karolinska Institutet
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Frye, Mark (author)
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Fullerton, Janice (author)
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Gallo, Carla (author)
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Gard, Sebastien (author)
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Garnham, Julie (author)
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Goes, Fernando (author)
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Grigoroiu-Serbanescu, Maria (author)
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Grof, Paul (author)
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Hashimoto, Ryota (author)
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Hasler, Roland (author)
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Hauser, Joanna (author)
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Heilbronner, Urs (author)
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Herms, Stefan (author)
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Hoffmann, Per (author)
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Hou, Liping (author)
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Hsu, YiHsiang (author)
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Jamain, Stéphane (author)
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Jiménez, Esther (author)
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Kahn, Jean-Pierre (author)
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Kassem, Layla (author)
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Kato, Tadafumi (author)
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Kelsoe, John (author)
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Kittel-Schneider, Sarah (author)
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Kuo, Po-Hsiu (author)
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Kurtz, Joachim (author)
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Kusumi, Ichiro (author)
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König, Barbara (author)
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Laje, Gonzalo (author)
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- Landén, Mikael, 1966 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Lavebratt, Catharina (author)
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Leboyer, Marion (author)
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Leckband, Susan (author)
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- Maj, Mario (author)
- Karolinska Institutet
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Manchia, Mirko (author)
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Marie-Claire, Cynthia (author)
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- Martinsson, Lina (author)
- Karolinska Institutet
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McCarthy, Michael (author)
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McElroy, Susan L (author)
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- Millischer, Vincent (author)
- Karolinska Institutet
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Mitjans, Marina (author)
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Mondimore, Francis (author)
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Monteleone, Palmiero (author)
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Nievergelt, Caroline (author)
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Novak, Tomas (author)
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Nöthen, Markus (author)
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Odonovan, Claire (author)
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Ozaki, Norio (author)
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Papiol, Sergi (author)
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Pfennig, Andrea (author)
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Pisanu, Claudia (author)
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Potash, James (author)
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Reif, Andreas (author)
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Reininghaus, Eva (author)
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Richard-Lepouriel, Hélène (author)
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Roberts, Gloria (author)
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Rouleau, Guy (author)
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Rybakowski, Janusz K (author)
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Schalling, Martin (author)
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Schofield, Peter (author)
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Schubert, Klaus Oliver (author)
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Schulte, Eva (author)
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Schweizer, Barbara (author)
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Severino, Giovanni (author)
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Shekhtman, Tatyana (author)
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Shilling, Paul (author)
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Shimoda, Kazutaka (author)
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Simhandl, Christian (author)
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Slaney, Claire (author)
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Squassina, Alessio (author)
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Stamm, Thomas (author)
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Stopkova, Pavla (author)
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Streit, Fabian (author)
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Ayele, Fasil (author)
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Tortorella, Alfonso (author)
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Turecki, Gustavo (author)
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Veeh, Julia (author)
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Vieta, Eduard (author)
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Viswanath, Biju (author)
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Witt, Stephanie (author)
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Zandi, Peter (author)
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Alda, Martin (author)
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Bauer, Michael (author)
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McMahon, Francis (author)
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Mitchell, Philip (author)
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Rietschel, Marcella (author)
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Schulze, Thomas (author)
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Baune, Bernhard (author)
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(creator_code:org_t)
- 2023
- English.
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In: Research square.
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.2...
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http://kipublication...
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Abstract
Subject headings
Close
- The link between bipolar disorder (BP) and immune dysfunction remains controversial. While epidemiological studies have long suggested an association, recent research has found only limited evidence of such a relationship. To clarify this, we investigated the contributions of immune-relevant genetic factors to the response to lithium (Li) treatment and the clinical presentation of BP. First, we assessed the association of a large collection of immune-related genes (4,925) with Li response, defined by the Retrospective Assessment of the Lithium Response Phenotype Scale (Alda scale), and clinical characteristics in patients with BP from the International Consortium on Lithium Genetics (ConLi+Gen, N = 2,374). Second, we calculated here previously published polygenic scores (PGSs) for immune-related traits and evaluated their associations with Li response and clinical features. We found several genes associated with Li response at p < 1×10- 4 values, including HAS3, CNTNAP5 and NFIB. Network and functional enrichment analyses uncovered an overrepresentation of pathways involved in cell adhesion and intercellular communication, which appear to converge on the well-known Li-induced inhibition of GSK-3β. We also found various genes associated with BP's age-at-onset, number of mood episodes, and presence of psychosis, substance abuse and/or suicidal ideation at the exploratory threshold. These included RTN4, XKR4, NRXN1, NRG1/3 and GRK5. Additionally, PGS analyses suggested serum FAS, ECP, TRANCE and cytokine ligands, amongst others, might represent potential circulating biomarkers of Li response and clinical presentation. Taken together, our results support the notion of a relatively weak association between immunity and clinically relevant features of BP at the genetic level.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Publication and Content Type
- vet (subject category)
- ovr (subject category)
To the university's database
- By the author/editor
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Herrera-Rivero, ...
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Gutiérrez-Fragos ...
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Thalamuthu, Anbu ...
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Amare, Azmeraw T
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Adli, Mazda
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Akiyama, Kazufum ...
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show more...
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Akula, Nirmala
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Ardau, Raffaella
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Arias, Bárbara
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Aubry, Jean-Mich ...
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Backlund, Lena
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Bellivier, Frank
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Benabarre, Anton ...
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Bengesser, Susan ...
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Abesh, Bhattacha ...
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Biernacka, Joann ...
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Birner, Armin
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Cearns, Micah
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Cervantes, Pablo
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Chen, Hsi-Chung
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Chillotti, Cater ...
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Cichon, Sven
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Clark, Scott
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Colom, Francesc
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Cruceanu, Cristi ...
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Czerski, Piotr
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Dalkner, Nina
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Degenhardt, Fran ...
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Del Zompo, Maria
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DePaulo, J Raymo ...
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Etain, Bruno
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Falkai, Peter
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Ferensztajn-Roch ...
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Forstner, Andrea ...
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Frank, Josef
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Frisen, Louise
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Frye, Mark
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Fullerton, Janic ...
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Gallo, Carla
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Gard, Sebastien
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Garnham, Julie
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Goes, Fernando
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Grigoroiu-Serban ...
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Grof, Paul
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Hashimoto, Ryota
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Hasler, Roland
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Hauser, Joanna
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Heilbronner, Urs
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Herms, Stefan
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Hoffmann, Per
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Hou, Liping
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Hsu, YiHsiang
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Jamain, Stéphane
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Jiménez, Esther
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Kahn, Jean-Pierr ...
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Kassem, Layla
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Kato, Tadafumi
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Kelsoe, John
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Kittel-Schneider ...
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Kuo, Po-Hsiu
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Kurtz, Joachim
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Kusumi, Ichiro
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König, Barbara
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Laje, Gonzalo
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Landén, Mikael, ...
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Lavebratt, Catha ...
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Leboyer, Marion
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Leckband, Susan
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Maj, Mario
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Manchia, Mirko
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Marie-Claire, Cy ...
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Martinsson, Lina
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McCarthy, Michae ...
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McElroy, Susan L
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Millischer, Vinc ...
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Mitjans, Marina
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Mondimore, Franc ...
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Monteleone, Palm ...
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Nievergelt, Caro ...
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Novak, Tomas
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Nöthen, Markus
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Odonovan, Claire
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Ozaki, Norio
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Papiol, Sergi
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Pfennig, Andrea
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Pisanu, Claudia
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Potash, James
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Reif, Andreas
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Reininghaus, Eva
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Richard-Lepourie ...
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Roberts, Gloria
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Rouleau, Guy
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Rybakowski, Janu ...
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Schalling, Marti ...
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Schofield, Peter
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Schubert, Klaus ...
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Schulte, Eva
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Schweizer, Barba ...
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Severino, Giovan ...
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Shekhtman, Tatya ...
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Shilling, Paul
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Shimoda, Kazutak ...
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Simhandl, Christ ...
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Slaney, Claire
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Squassina, Aless ...
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Stamm, Thomas
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Stopkova, Pavla
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Streit, Fabian
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Ayele, Fasil
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Tortorella, Alfo ...
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Turecki, Gustavo
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Veeh, Julia
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Vieta, Eduard
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Viswanath, Biju
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Witt, Stephanie
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Zandi, Peter
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Alda, Martin
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Bauer, Michael
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McMahon, Francis
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Mitchell, Philip
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Rietschel, Marce ...
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Schulze, Thomas
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Baune, Bernhard
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
- Research square
- By the university
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University of Gothenburg
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Karolinska Institutet