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Cellular immune act...
Cellular immune activity biomarker neopterin is associated hyperlipidemia : results from a large population-based study
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Chuang, Shu-Chun (author)
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Boeing, Heiner (author)
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Vollset, Stein Emil (author)
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Midttun, Oivind (author)
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Ueland, Per Magne (author)
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Bueno-de-Mesquita, Bas (author)
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Lajous, Martin (author)
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Fagherazzi, Guy (author)
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Boutron-Ruault, Marie-Christine (author)
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Kaaks, Rudolf (author)
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Kuehn, Tilman (author)
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Pischon, Tobias (author)
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Drogan, Dagmar (author)
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Tjonneland, Anne (author)
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Overvad, Kim (author)
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Quiros, J. Ramon (author)
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Agudo, Antonio (author)
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Molina-Montes, Esther (author)
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Dorronsoro, Miren (author)
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Maria Huerta, Jose (author)
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Barricarte, Aurelio (author)
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Khaw, Kay-Tee (author)
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Wareham, Nicholas J. (author)
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Travis, Ruth C. (author)
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Trichopoulou, Antonia (author)
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Lagiou, Pagona (author)
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Trichopoulos, Dimitrios (author)
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Masala, Giovanna (author)
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Agnoli, Claudia (author)
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Tumino, Rosario (author)
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Mattiello, Amalia (author)
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Peeters, Petra H. (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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- Palmqvist, Richard (author)
- Umeå universitet,Patologi
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- Ljuslinder, Ingrid (author)
- Umeå universitet,Onkologi
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Gunter, Marc (author)
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- Lu, Yunxia (author)
- Karolinska Institutet
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Cross, Amanda J. (author)
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Riboli, Elio (author)
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Vineis, Paolo (author)
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Aleksandrova, Krasimira (author)
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(creator_code:org_t)
- 2016-02-25
- 2016
- English.
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In: Immunity & Ageing. - : Springer Science and Business Media LLC. - 1742-4933. ; 13
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://immunityagei...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Background: Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC).Results: Higher total neopterin concentrations were associated with reduced HDLC (9.7 %, p < 0.01 for men and 9.2 %, p < 0.01 for women), whereas no association was observed with the rest of the MetS components as well as with MetS overall (per 10 nmol/L: OR = 1.42, 95 % CI = 0.85-2.39 for men and OR = 1.38, 95 % CI = 0.79-2.43).Conclusions: These data suggest that high total neopterin concentrations are cross-sectionally associated with reduced HDLC, but not with overall MetS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Neopterin
- Cell-mediated immunity
- Metabolic syndrome
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Chuang, Shu-Chun
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Boeing, Heiner
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Vollset, Stein E ...
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Midttun, Oivind
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Ueland, Per Magn ...
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Bueno-de-Mesquit ...
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show more...
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Lajous, Martin
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Fagherazzi, Guy
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Boutron-Ruault, ...
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Kaaks, Rudolf
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Kuehn, Tilman
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Pischon, Tobias
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Drogan, Dagmar
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Tjonneland, Anne
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Overvad, Kim
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Quiros, J. Ramon
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Agudo, Antonio
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Molina-Montes, E ...
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Dorronsoro, Mire ...
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Maria Huerta, Jo ...
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Barricarte, Aure ...
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Khaw, Kay-Tee
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Wareham, Nichola ...
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Travis, Ruth C.
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Trichopoulou, An ...
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Lagiou, Pagona
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Trichopoulos, Di ...
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Masala, Giovanna
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Agnoli, Claudia
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Tumino, Rosario
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Mattiello, Amali ...
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Peeters, Petra H ...
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Weiderpass, Elis ...
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Palmqvist, Richa ...
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Ljuslinder, Ingr ...
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Gunter, Marc
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Lu, Yunxia
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Cross, Amanda J.
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Riboli, Elio
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Vineis, Paolo
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Aleksandrova, Kr ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Immunity & Agein ...
- By the university
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Umeå University
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Karolinska Institutet