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Double-strand break DNA repair genotype predictive of later mortality and cancer incidence in a cohort of non-smokers

Neasham, David (author)
Gallo, Valentina (author)
Guarrera, Simonetta (author)
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Dunning, Alison (author)
Overvad, Kim (author)
Tjonneland, Anne (author)
Clavel-Chapelon, Francoise (author)
Linseisen, Jakob P. (author)
Malaveille, Christian (author)
Ferrari, Pietro (author)
Boeing, Heiner (author)
Benetou, Vassiliki (author)
Trichopoulou, Antonia (author)
Palli, Domenico (author)
Crosignani, Paolo (author)
Tumino, Rosario (author)
Panico, Salvatore (author)
Bueno-De-Mesquita, H. Bas (author)
Peeters, Petra H. (author)
van Gib, Carla H. (author)
Lund, Eiliv (author)
Gonzalez, Carlos A. (author)
Martinez, Carmen (author)
Dorronsoro, Miren (author)
Barricarte, Aurelio (author)
Navarro, Carmen (author)
Quiros, Jose R. (author)
Berglund, Göran (author)
Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
Jarvholm, Bengt (author)
Umeå universitet,Yrkes- och miljömedicin
Khaw, Kay Tee (author)
Key, Timothy J. (author)
Bingham, Sheila (author)
Jose Diaz, Tormo M. (author)
Riboli, Elio (author)
Matullo, Giuseppe (author)
Vineis, Paolo (author)
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 (creator_code:org_t)
Elsevier BV, 2009
2009
English.
In: DNA Repair. - : Elsevier BV. - 1568-7856 .- 1568-7864. ; 8:1, s. 60-71
Related links:
http://dx.doi.org/10...
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https://lup.lub.lu.s...
https://doi.org/10.1...
https://urn.kb.se/re...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • We followed-up for mortality and cancer incidence 1088 healthy non-smokers from a population-based study, who were characterized for 22 variants in 16 genes involved in DNA repair pathways. Follow-up was 100% complete. The association between polymorphism and mortality or cancer incidence was analyzed using Cox Proportional Hazard regression models. Ninety-five subjects had died in a median follow-up time of 78 months (inter-quartile range 59-93 months). None of the genotypes was clearly associated with total mortality, except variants for two Double-Strand Break DNA repair genes, XRCC3 18067 C > T (rs#861539) and XRCC2 31479 G > A (rs#3218536). Adjusted hazard ratios were 2.25 (1.32-3.83) for the XRCC3 C/T genotype and 2.04 (1.00-4.13) for the T/T genotype (reference C/C), and 2.12 (1.14-3.97) for the XRCC2 G/A genotype (reference G/G). For total cancer mortality, the adjusted hazard ratios were 3.29 (1.23-7.82) for XRCC3 C/T, 2.84 (0.81-9.90) for XRCC3 T/T and 3.17 (1.21-8.30) for XRCC2 G/A. With combinations of three or more adverse alleles, the adjusted hazard ratio for all cause mortality was 17.29 (95% C.I. 8.13-36.74), and for all incident cancers the HR was 5.28 (95% C.I. 2.17-12.85). Observations from this prospective study suggest that polymorphisms of genes involved in the repair of DNA double-strand breaks significantly influence the risk of cancer and non-cancer disease, and call influence mortality. (C) 2008 Elsevier B.V. All rights reserved.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)

Keyword

Mortality
DNA repair
Prospective study
Cancer

Publication and Content Type

art (subject category)
ref (subject category)

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