(WFRF:(Holmberg Dan))
Search: (WFRF:(Holmberg Dan)) > (2010-2014) > Global and 3D Spati...
- 8 of 25
- Previous record
- Next record
- To hitlist
Global and 3D Spatial Assessment of Neuroinflammation in Rodent Models of Multiple Sclerosis.
-
- Gupta, Shashank (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
- Utoft, Regine (author)
- Hasseldam, Henrik (author)
- show more...
- Agarwal-Gupta, Noopur (author)
- Rozell, Björn (author)
- show less...
- (creator_code:org_t)
- 2013-10-04
- 2013
- English.
- In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:10
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Multiple Sclerosis (MS) is a progressive autoimmune inflammatory and demyelinating disease of the central nervous system (CNS). T cells play a key role in the progression of neuroinflammation in MS and also in the experimental autoimmune encephalomyelitis (EAE) animal models for the disease. A technology for quantitative and 3 dimensional (3D) spatial assessment of inflammation in this and other CNS inflammatory conditions is much needed. Here we present a procedure for 3D spatial assessment and global quantification of the development of neuroinflammation based on Optical Projection Tomography (OPT). Applying this approach to the analysis of rodent models of MS, we provide global quantitative data of the major inflammatory component as a function of the clinical course. Our data demonstrates a strong correlation between the development and progression of neuroinflammation and clinical disease in several mouse and a rat model of MS refining the information regarding the spatial dynamics of the inflammatory component in EAE. This method provides a powerful tool to investigate the effect of environmental and genetic forces and for assessing the therapeutic effects of drug therapy in animal models of MS and other neuroinflammatory/neurodegenerative disorders.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
- 8 of 25
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Gupta, Shashank
- Utoft, Regine
- Hasseldam, Henri ...
- Schmidt-Christen ...
- Hannibal, Tine
- Hansen, Lisbeth
- show more...
- Fransén Petterss ...
- Agarwal-Gupta, N ...
- Rozell, Björn
- Andersson, Åsa
- Holmberg, Dan
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- Articles in the publication
- PLoS ONE
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
