(WFRF:(Iacoviello Licia)) pers:(Moreno Luis A)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04307naa a2200541 4500 | |
| 001 | oai:gup.ub.gu.se/285942 | |
| 003 | SwePub | |
| 008 | 240910s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2859422 URI |
| 024 | 7 | a https://doi.org/10.1016/j.appet.2019.1043762 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Grippi, Claudio4 aut |
| 245 | 1 0 | a Association between variants of neuromedin U gene and taste thresholds and food preferences in European children: Results from the IDEFICS study. |
| 264 | 1 | b Elsevier BV,c 2019 |
| 520 | a The neuropeptide neuromedin U (NMU) known for its role in appetite, feeding and energy balance could be involved in the control of food choice and taste sensitivity. We examined the association between NMU polymorphisms/haplotypes and taste thresholds and food preferences in a population of European children.A total of 578 subjects from the IDEFICS study (mean age 7.5±0.8 SD, boys 53.6%) with NMU genotype data and food preference (salty, fatty, sweet, flavour and umami food) and taste threshold (salt, fat, sweet, umami) tests available were analysed. Three single nucleotide polymorphisms (SNPs; rs6827359, T:C; rs12500837, T:C; rs9999653, C:T) of NMU gene were analyzed and five major haplotypes were inferred. The associations between genotypes and food preferences or taste thresholds were investigated (odds ratios -OR, adjusted for age, sex and country). A p<0.05 after false discovery rate adjustment (pFDR) was considered statistically significant.The association between NMU genotypes and food preference showed two NMU SNPs associated with preference for food containing sodium glutamate (umami taste; rs6827359C, OR=1.61, 95% confidence interval (CI):1.20-2.17; rs9999653T, OR=1.59, 95%CI:1.18-2.13). In the haplotype analysis, the CTT haplotype showed an OR of 1.70 (95%CI:1.16-2.5) for the umami food preference, while CCT haplotype showed an OR of 1.63 (95%CI:1.11-2.40), compared to the most frequent haplotype (TTC). Carriers of CCT/CCT vs subjects with no CCT haplotype showed an OR of 4.78 (95%CI:1.86-12.30). Umami food preference was associated with low values of BMI z-score, arm circumferences, skinfolds and fat mass (pFDR<0.05). No association between NMU genetic variants and taste thresholds was found.This study shows for the first time in children an association between preference for umami food and a NMU haplotype, previously found associated with low BMI values. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
| 653 | a Food preferences | |
| 653 | a Genetics | |
| 653 | a Neurology | |
| 653 | a Neuromedin U | |
| 653 | a Obesity | |
| 653 | a Umami | |
| 700 | 1 | a Ahrens, Wolfgang4 aut |
| 700 | 1 | a Buchecker, Kirsten4 aut |
| 700 | 1 | a Chadjigeorgiou, Charalambos4 aut |
| 700 | 1 | a De Henauw, Stefaan4 aut |
| 700 | 1 | a Koni, Anna C4 aut |
| 700 | 1 | a Foraita, Ronja4 aut |
| 700 | 1 | a Lissner, Lauren,d 1956u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine4 aut0 (Swepub:gu)xlisla |
| 700 | 1 | a Molnár, Denés4 aut |
| 700 | 1 | a Moreno, Luis A4 aut |
| 700 | 1 | a Pitsiladis, Yannis4 aut |
| 700 | 1 | a Reisch, Lucia A4 aut |
| 700 | 1 | a Russo, Paola4 aut |
| 700 | 1 | a Siani, Alfonso4 aut |
| 700 | 1 | a Veidebaum, Toomas4 aut |
| 700 | 1 | a Iacoviello, Licia4 aut |
| 700 | 1 | a Gianfagna, Francesco4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa4 org |
| 773 | 0 | t Appetited : Elsevier BVg 142q 142x 1095-8304x 0195-6663 |
| 856 | 4 | u https://research-api.cbs.dk/ws/files/61377558/lucia_a_reisch_et_al_association_between_variants_acceptedmanuscript.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/285942 |
| 856 | 4 8 | u https://doi.org/10.1016/j.appet.2019.104376 |
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