Search: (WFRF:(Kaaks Rudolf)) srt2:(2015-2019) pers:(Weiderpass Elisabete) pers:(Quirós J. Ramón)
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Alteration of amino...
Alteration of amino acid and biogenic amine metabolism in hepatobiliary cancers : findings from a prospective cohort study
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Stepien, Magdalena (author)
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Duarte-Salles, Talita (author)
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Fedirko, Veronika (author)
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show more...
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Floegel, Anne (author)
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Barupal, Dinesh Kumar (author)
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Rinaldi, Sabina (author)
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Achaintre, David (author)
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Assi, Nada (author)
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Tjønneland, Anne (author)
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Overvad, Kim (author)
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Bastide, Nadia (author)
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Boutron-Ruault, Marie-Christine (author)
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Severi, Gianluca (author)
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Kühn, Tilman (author)
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Kaaks, Rudolf (author)
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Aleksandrova, Krasimira (author)
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Boeing, Heiner (author)
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Trichopoulou, Antonia (author)
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Bamia, Christina (author)
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Lagiou, Pagona (author)
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Saieva, Calogero (author)
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Agnoli, Claudia (author)
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Panico, Salvatore (author)
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Tumino, Rosario (author)
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Naccarati, Alessio (author)
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Bueno-de-Mesquita, H Bas (author)
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Peeters, Petra H (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Quirós, J Ramón (author)
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Agudo, Antonio (author)
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Sánchez, María-José (author)
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Dorronsoro, Miren (author)
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Gavrila, Diana (author)
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Barricarte, Aurelio (author)
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- Ohlsson, Bodil (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Sjöberg, Klas (author)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups
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- Werner, Mårten (author)
- Umeå universitet,Medicin
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- Sund, Malin (author)
- Umeå universitet,Kirurgi
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Wareham, Nick (author)
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Khaw, Kay-Tee (author)
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Travis, Ruth C (author)
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Schmidt, Julie A (author)
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Gunter, Marc (author)
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Cross, Amanda (author)
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Vineis, Paolo (author)
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Romieu, Isabelle (author)
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Scalbert, Augustin (author)
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Jenab, Mazda (author)
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(creator_code:org_t)
- 2015-08-21
- 2016
- English.
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In: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 138:2, s. 348-360
- Related links:
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https://onlinelibrar...
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Subject headings
Close
- Perturbations in levels of amino acids (AA) and their derivatives are observed in hepatocellular carcinoma (HCC). Yet, it is unclear whether these alterations precede or are a consequence of the disease, nor whether they pertain to anatomically related cancers of the intrahepatic bile duct (IHBC), and gallbladder and extrahepatic biliary tract (GBTC). Circulating standard AA, biogenic amines and hexoses were measured (Biocrates AbsoluteIDQ-p180Kit) in a case-control study nested within a large prospective cohort (147 HCC, 43 IHBC and 134 GBTC cases). Liver function and hepatitis status biomarkers were determined separately. Multivariable conditional logistic regression was used to calculate odds ratios and 95% confidence intervals (OR; 95%CI) for log-transformed standardised (mean = 0, SD = 1) serum metabolite levels and relevant ratios in relation to HCC, IHBC or GBTC risk. Fourteen metabolites were significantly associated with HCC risk, of which seven metabolites and four ratios were the strongest predictors in continuous models. Leucine, lysine, glutamine and the ratio of branched chain to aromatic AA (Fischer's ratio) were inversely, while phenylalanine, tyrosine and their ratio, glutamate, glutamate/glutamine ratio, kynurenine and its ratio to tryptophan were positively associated with HCC risk. Confounding by hepatitis status and liver enzyme levels was observed. For the other cancers no significant associations were observed. In conclusion, imbalances of specific AA and biogenic amines may be involved in HCC development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- hepatocellular carcinoma
- biliary tract cancers
- prospective cohort
- targeted metabolomics
- amino acids
Publication and Content Type
- ref (subject category)
- art (subject category)
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Stepien, Magdale ...
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Duarte-Salles, T ...
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Fedirko, Veronik ...
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Floegel, Anne
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Barupal, Dinesh ...
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Rinaldi, Sabina
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show more...
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Achaintre, David
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Assi, Nada
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Tjønneland, Anne
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Overvad, Kim
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Bastide, Nadia
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Boutron-Ruault, ...
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Severi, Gianluca
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Kühn, Tilman
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Kaaks, Rudolf
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Aleksandrova, Kr ...
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Boeing, Heiner
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Trichopoulou, An ...
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Bamia, Christina
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Lagiou, Pagona
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Saieva, Calogero
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Agnoli, Claudia
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Panico, Salvator ...
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Tumino, Rosario
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Naccarati, Aless ...
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Bueno-de-Mesquit ...
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Peeters, Petra H
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Weiderpass, Elis ...
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Quirós, J Ramón
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Agudo, Antonio
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Sánchez, María-J ...
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Dorronsoro, Mire ...
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Gavrila, Diana
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Barricarte, Aure ...
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Ohlsson, Bodil
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Sjöberg, Klas
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Werner, Mårten
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Sund, Malin
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Wareham, Nick
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Khaw, Kay-Tee
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Travis, Ruth C
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Schmidt, Julie A
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Gunter, Marc
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Cross, Amanda
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Vineis, Paolo
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Romieu, Isabelle
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Scalbert, August ...
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Jenab, Mazda
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
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International Jo ...
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Umeå University
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Lund University
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Karolinska Institutet