(WFRF:(Li X.)) lar1:(liu)
Search: (WFRF:(Li X.)) lar1:(liu) > (2005-2009) > Down-regulation of ...
- 8 of 8
- Previous record
- Next record
- To hitlist
Down-regulation of tumor necrosis factor-associated factor 6 is associated with progression of acute pancreatitis complicating lung injury in mice
-
- Zhou, X. (author)
- Sichuan University
-
- Li, Y. (author)
- Sichuan University
-
- Ding, J. (author)
- Sichuan University
- show more...
- show less...
- (creator_code:org_t)
- Tohoku University Medical Press, 2009
- 2009
- English.
- In: Tohoku Journal of Experimental Medicine. - : Tohoku University Medical Press. - 0040-8727 .- 1349-3329. ; 217:4, s. 279-285
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Acute lung injury is one of the critical complications of acute pancreatitis (AP). Tumor necrosis factor-associated factor 6 (TRAF6) is a key adaptor that regulates various inflammatory signaling pathways, including those mediated by Toll-like receptors (TLRs). This study was performed to investigate the potential role of TRAF6 in the pathogenesis of AP and pancreatitis-associated acute lung injury using a mouse model of caerulein-induced AP (CAP). CAP was induced by intraperitoneal injection of caerulein hourly for 7 times (50 µg/kg), and control mice were treated with saline of the same volume. Typical pancreatic and lung inflammation was observed in the early stage (1 h) of CAP, as judged by morphological changes. Likewise, in CAP mice, the pancreatic myeloperoxidase activity and serum levels of interleukin-6 add interleukin-10 were significantly increased after 2 h, peaked it 4h, and then decreased by 24 h. The expression of TRAF6 was then studied by real time-PCR, immunohistochemistry, and Western blot analysis. Compared with control group, TRAF6 mRNA level was decreased in CAP group within the first 12 h, and then significantly increased after 24 h, which was in accordance with the protein level detected by Western blot analysis and immunohistochemistry. Moreover, TRAF6 protein was expressed in both pancreatic acinar cells and lung bronchial epithelial cells. In conclusion, the down-regulation of TRAF6 was associated with increased inflammatory severity in the pancreas and lung, suggesting that TRAF6 is involved in the anti-inflammatory process during AP. TRAF6 may be a potential molecular target for treating AP.
Keyword
- Acute lung injury; Acute pancreatitis; Inflammatio; Pathogenesis; Tumor necrosis factor-associated factor 6
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Tohoku Journal of Experimental Medicine (Search for host publication in LIBRIS)
To the university's database
- 8 of 8
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Zhou, X.
- Li, Y.
- Ding, J.
- Wang, L.
- Wang, R.
- Zhou, B.
- show more...
- Gu, J.
- Sun, Xiao-Feng
- Zhou, Z.
- show less...
- Articles in the publication
- Tohoku Journal o ...
- By the university
- Linköping University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
