Genetic Predictors of Change in Waist Circumference and Waist-to-Hip Ratio With Lifestyle Intervention : The Trans-NIH Consortium for Genetics of Weight Loss Response to Lifestyle Intervention

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Fältnamn	Indikatorer	Metadata
000		04847naa a2200565 4500
001		oai:lup.lub.lu.se:6bcbf607-ae3a-45ea-b9af-336a3f7bc45a
003		SwePub
008		230120s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/6bcbf607-ae3a-45ea-b9af-336a3f7bc45a2 URI
024	7	a https://doi.org/10.2337/db21-07412 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a McCaffery, Jeanne M.u University of Connecticut4 aut
245	1 0	a Genetic Predictors of Change in Waist Circumference and Waist-to-Hip Ratio With Lifestyle Intervention : The Trans-NIH Consortium for Genetics of Weight Loss Response to Lifestyle Intervention
264		c 2022-01-18
264	1	b American Diabetes Association,c 2022
300		a 8 s.
520		a Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) associated with waist circumference (WC) and waist-to-hip ratio (WHR) adjusted for BMI (WCadjBMI and WHRadjBMI), but it remains unclear whether these SNPs relate to change in WCadjBMI or WHRadjBMI with lifestyle intervention for weight loss. We hypothesized that polygenic scores (PS) comprised of 59 SNPs previously associated with central adiposity would predict less of a reduction in WCadjBMI or WHRadjBMI at 8-10 weeks in two lifestyle intervention trials, NUGENOB and DiOGenes, and at 1 year in five lifestyle intervention trials, Look AHEAD, Diabetes Prevention Program, Diabetes Prevention Study, DIETFITS, and PREDIMED-Plus. One-SD higher PS related to a smaller 1-year change in WCadjBMI in the lifestyle intervention arms at year 1 and thus predicted poorer response (β = 0.007; SE = 0.003; P = 0.03) among White participants overall and in White men (β = 0.01; SE = 0.004; P = 0.01). At average weight loss, this amounted to 0.20-0.28 cm per SD. No significant findings emerged in White women or African American men for the 8-10-week outcomes or for WHRadjBMI. Findings were heterogeneous in African American women. These results indicate that polygenic risk estimated from these 59 SNPs relates to change in WCadjBMI with lifestyle intervention, but the effects are small and not of sufficient magnitude to be clinically significant.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
700	1	a Jablonski, Kathleen A.u George Washington University4 aut
700	1	a Pan, Qingu George Washington University4 aut
700	1	a Astrup, Arneu Novo Nordisk Foundation4 aut
700	1	a Revsbech Christiansen, Maleneu University of Copenhagen4 aut
700	1	a Corella, Doloresu University of Valencia4 aut
700	1	a Corso, Lauren M.L.u University of Connecticut4 aut
700	1	a Florez, Jose C.u Massachusetts General Hospital,Harvard Medical School,Broad Institute4 aut
700	1	a Franks, Paul W.u Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University4 aut0 (Swepub:lu)med-plf
700	1	a Gardner, Christopheru Stanford University School of Medicine4 aut
700	1	a Hansen, Torbenu University of Copenhagen4 aut
700	1	a Kilpeläinen, Tuomas O.u University of Copenhagen4 aut
700	1	a Knowler, William C.u National Institute of Diabetes and Digestive and Kidney Diseases4 aut
700	1	a Lindström, Jaanau Finnish National Institute for Health and Welfare4 aut
700	1	a Saris, Wim H.M.u Maastricht University4 aut
700	1	a Sørensen, Thorkild I.A.u University of Copenhagen4 aut
700	1	a Tuomilehto, Jaakkou King Abdulaziz University,Finnish National Institute for Health and Welfare,University of Helsinki4 aut
700	1	a Uusitupa, Mattiu University of Eastern Finland4 aut
700	1	a Wing, Rena R.u Brown University4 aut
700	1	a Agurs-Collins, Tanyau National Cancer Institute, USA4 aut
710	2	a University of Connecticutb George Washington University4 org
773	0	t Diabetesd : American Diabetes Associationg 71:4, s. 669-676q 71:4<669-676x 1939-327Xx 0012-1797
856	4	u http://dx.doi.org/10.2337/db21-0741y FULLTEXT
856	4	u https://doi.org/10.2337/figshare.17890715
856	4 8	u https://lup.lub.lu.se/record/6bcbf607-ae3a-45ea-b9af-336a3f7bc45a
856	4 8	u https://doi.org/10.2337/db21-0741

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