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Difficulties and possibilities with thiopurine therapy in inflammatory bowel disease-Proceedings of the first Thiopurine Task Force meeting

van Asseldonk, Dirk P (author)
Vrije University Amsterdam Medical Centre, Amsterdam, The Netherlands
Sanderson, Jeremy (author)
Guys and St Thomas Hospital, London, UK
de Boer, Nanne K H (author)
Vrije University Amsterdam Medical Centre, Amsterdam, The Netherlands
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Sparrow, Miles P (author)
Alfred Hospital, Melbourne, Australia
Lemann, Marc (author)
Hôpital Saint Louis, Paris, France
Ansari, Azhar (author)
East Surrey Hospital, Red Hill, UK
Almer, Sven (author)
Östergötlands Läns Landsting,Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US
Florin, Timothy H J (author)
University of Queensland, Brisbane, Australia
Gearry, Richard B (author)
University of Otago, Christchurch, New Zealand
Mulder, Chris J (author)
Vrije University Amsterdam Medical Centre, Amsterdam, The Netherlands
Mantzaris, Gerassimos (author)
Evangelisms Hospital, Athens, Greece
van Bodegraven, Ad A (author)
Vrije University Amsterdam Medical Centre, Amsterdam, The Netherlands
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 (creator_code:org_t)
Elsevier Science B.V., Amsterdam, 2011
2011
English.
In: DIGESTIVE AND LIVER DISEASE. - : Elsevier Science B.V., Amsterdam. - 1590-8658. ; 43:4, s. 270-276
Related links:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background: Thiopurines, such as azathioprine and mercaptopurine, are of pivotal importance in the treatment of inflammatory bowel disease. Although these drugs have been used for several decades, still many questions remain unanswered. Aim: To provide an overview of clinically and scientifically challenging topics concerning thiopurine therapy in inflammatory bowel disease treatment. Methods: The first meeting of the Thiopurine Task Force Interest Group was held during the 2009 United European Gastroenterology Week in London (GASTRO2009). The topics of this meeting were of particular clinical and scientific interest. Additional literature was identified by performing a Pubmed search using the search terms inflammatory bowel disease, azathioprine, 6-mercaptopurine and thioguanine. Results: The following topics were discussed: therapeutic drug monitoring; the synergy of thiopurines with aminosalicylates and allopurinol; serious adverse events such as opportunistic infections, hepatotoxicity, carcinogenicity and pancreatitis; prolongation of thiopurines during clinical remission; indications for thiopurines in the postoperative setting; and the potential use of thioguanine. Specific interesting and clinically relevant topics for potential future research are provided. Conclusions: Thiopurines remain central to inflammatory bowel disease treatment, although future studies are required to substantiate a more personalised medicine approach to their use.

Keyword

Adverse events
Inflammatory bowel disease
Therapeutic drug monitoring
Thiopurines
MEDICINE
MEDICIN

Publication and Content Type

ref (subject category)
art (subject category)

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