Sökning: (WFRF:(Ngwa Julius S.)) > Higher Magnesium In...
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000 | 07739naa a2201129 4500 | |
001 | oai:DiVA.org:umu-67583 | |
003 | SwePub | |
008 | 130325s2013 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:60557ad5-7923-447d-b86a-8b851fb62f88 | |
009 | oai:DiVA.org:uu-197380 | |
009 | oai:prod.swepub.kib.ki.se:126230314 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-675832 URI |
024 | 7 | a https://doi.org/10.3945/jn.112.1720492 DOI |
024 | 7 | a https://lup.lub.lu.se/record/36715352 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1973802 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1262303142 URI |
040 | a (SwePub)umud (SwePub)lud (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hruby, Adela4 aut |
245 | 1 0 | a Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies |
264 | 1 | b Elsevier BV,c 2013 |
338 | a print2 rdacarrier | |
520 | a Favorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that single nucleotide polymorphisms (SNPs) associated with either glycemic traits or magnesium metabolism affect the association between magnesium intake and fasting glucose and insulin. Fifteen studies from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium provided data from up to 52,684 participants of European descent without known diabetes. In fixed-effects meta-analyses, we quantified 1) cross-sectional associations of dietary magnesium intake with fasting glucose (mmol/L) and insulin (In-pmol/L) and 2) interactions between magnesium intake and SNPs related to fasting glucose (16 SNPs), insulin (2 SNPs), or magnesium (8 SNPs) on fasting glucose and insulin. After adjustment for age, sex, energy intake, BMI, and behavioral risk factors, magnesium (per 50-mg/d increment) was inversely associated with fasting glucose [beta = -0.009 mmol/L (95% CI: -0.013, -0.005), P< 0.0001] and insulin (-0.020 In-pmo/L (95% CI: -0.024, -0.017), P< 0.0001]. No magnesium-related SNP or interaction between any SNP and magnesium reached significance after correction for multiple testing. However, rs2274924 in magnesium transporter-encoding TRPM6 showed a nominal association (uncorrected P= 0.03) with glucose, and rs11558471 in SLC30A8and rs3740393 near CNNM2showed a nominal interaction (uncorrected, both P = 0.02) with magnesium on glucose. Consistent with other studies, a higher magnesium intake was associated with lower fasting glucose and insulin. Nominal evidence of TRPM6 influence and magnesium interaction with select loci suggests that further investigation is warranted. J. Nutr. 143: 345-353, 2013. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
700 | 1 | a Ngwa, Julius S.4 aut |
700 | 1 | a Renström, Fridau Lund University,Lunds universitet,Umeå universitet,Medicin,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-frm |
700 | 1 | a Wojczynski, Mary K.4 aut |
700 | 1 | a Ganna, Andreau Karolinska Institutet4 aut |
700 | 1 | a Hallmans, Göranu Umeå universitet,Näringsforskning,Enheten för biobanksforskning4 aut0 (Swepub:umu)goha0001 |
700 | 1 | a Houston, Denise K.4 aut |
700 | 1 | a Franks, Paulu Umeå universitet,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Medicin4 aut0 (Swepub:umu)pafr0003 |
700 | 1 | a Kanoni, Stavroula4 aut |
700 | 1 | a Lehtimaki, Terho4 aut |
700 | 1 | a Lemaitre, Rozenn N.4 aut |
700 | 1 | a Manichaikul, Ani4 aut |
700 | 1 | a North, Kari E.4 aut |
700 | 1 | a Ntalla, Ioanna4 aut |
700 | 1 | a Sonestedt, Emilyu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)medf-eso |
700 | 1 | a Tanaka, Toshiko4 aut |
700 | 1 | a van Rooij, Frank J. A.4 aut |
700 | 1 | a Bandinelli, Stefania4 aut |
700 | 1 | a Djousse, Luc4 aut |
700 | 1 | a Grigoriou, Efi.4 aut |
700 | 1 | a Johansson, Ingegerdu Umeå universitet,Tandläkarutbildning4 aut0 (Swepub:umu)injo0003 |
700 | 1 | a Lohman, Kurt K.4 aut |
700 | 1 | a Pankow, James S.4 aut |
700 | 1 | a Raitakari, Olli T.4 aut |
700 | 1 | a Riserus, Ulfu Uppsala universitet,Klinisk nutrition och metabolism4 aut0 (Swepub:uu)ulfriser |
700 | 1 | a Yannakoulia, Mary4 aut |
700 | 1 | a Zillikens, M. Carola4 aut |
700 | 1 | a Hassanali, Neelam4 aut |
700 | 1 | a Liu, Yongmei4 aut |
700 | 1 | a Mozaffarian, Dariush4 aut |
700 | 1 | a Papoutsakis, Constantina4 aut |
700 | 1 | a Syvänen, Ann-Christineu Uppsala universitet,Molekylär medicin4 aut0 (Swepub:uu)anncsyva |
700 | 1 | a Uitterlinden, Andre G.4 aut |
700 | 1 | a Viikari, Jorma4 aut |
700 | 1 | a Groves, Christopher J.4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind |
700 | 1 | a McCarthy, Mark I.4 aut |
700 | 1 | a Mikkila, Vera4 aut |
700 | 1 | a Mukamal, Kenneth4 aut |
700 | 1 | a Franco, Oscar H.4 aut |
700 | 1 | a Borecki, Ingrid B.4 aut |
700 | 1 | a Cupples, L. Adrienne4 aut |
700 | 1 | a Dedoussis, George V.4 aut |
700 | 1 | a Ferrucci, Luigi4 aut |
700 | 1 | a Hu, Frank B.4 aut |
700 | 1 | a Ingelsson, Erik4 aut |
700 | 1 | a Kahonen, Mika4 aut |
700 | 1 | a Kao, W. H. Linda4 aut |
700 | 1 | a Kritchevsky, Stephen B.4 aut |
700 | 1 | a Orho-Melander, Marjuu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor |
700 | 1 | a Prokopenko, Inga4 aut |
700 | 1 | a Rotter, Jerome I.4 aut |
700 | 1 | a Siscovick, David S.4 aut |
700 | 1 | a Witteman, Jacqueline C. M.4 aut |
700 | 1 | a Franks, Paul W.u Umeå universitet,Medicin4 aut0 (Swepub:umu)pafr0003 |
700 | 1 | a Meigs, James B.4 aut |
700 | 1 | a McKeown, Nicola M.4 aut |
700 | 1 | a Nettleton, Jennifer A.4 aut |
710 | 2 | a Umeå universitetb Medicin4 org |
773 | 0 | t Journal of Nutritiond : Elsevier BVg 143:3, s. 345-353q 143:3<345-353x 0022-3166x 1541-6100 |
856 | 4 | u https://academic.oup.com/jn/article-pdf/143/3/345/23977044/345.pdf |
856 | 4 | u http://dx.doi.org/10.3945/jn.112.172049y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-67583 |
856 | 4 8 | u https://doi.org/10.3945/jn.112.172049 |
856 | 4 8 | u https://lup.lub.lu.se/record/3671535 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-197380 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:126230314 |
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