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Which ante mortem c...
Which ante mortem clinical features predict progressive supranuclear palsy pathology?
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- Respondek, Gesine (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,Technical University of Munich
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- Kurz, Carolin (author)
- World Orthopaedic Concern
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- Arzberger, Thomas (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,World Orthopaedic Concern
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- Compta, Yaroslau (author)
- Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS)
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- Englund, Elisabet (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Ferguson, Leslie W. (author)
- Royal University Hospital, Saskatoon
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- Gelpi, Ellen (author)
- University of Barcelona
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- Giese, Armin (author)
- World Orthopaedic Concern
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- Irwin, David J. (author)
- University of Pennsylvania
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- Meissner, Wassilios G. (author)
- Groupe Hospitalier Pellegrin,University of Bordeaux,Versailles Saint-Quentin-en-Yvelines University
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- Nilsson, Christer (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Pantelyat, Alexander (author)
- Johns Hopkins University
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- Rajput, Alex (author)
- Royal University Hospital, Saskatoon
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- van Swieten, John C. (author)
- Erasmus University Medical Center
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- Troakes, Claire (author)
- King's College London
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- Josephs, Keith A. (author)
- Mayo Clinic Minnesota
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- Lang, Anthony E. (author)
- Toronto Western Hospital
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- Mollenhauer, Brit (author)
- University Medical Center Göttingen
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- Müller, Ulrich (author)
- Justus Liebig University Giessen
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- Whitwell, Jennifer L. (author)
- Mayo Clinic Minnesota
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- Antonini, Angelo (author)
- University of Padova
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- Bhatia, Kailash P. (author)
- University College London
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- Bordelon, Yvette (author)
- University of California, Los Angeles
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- Corvol, Jean Christophe (author)
- Versailles Saint-Quentin-en-Yvelines University,Pitié-Salpêtrière University Hospital
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- Colosimo, Carlo (author)
- Santa Maria University Hospital
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- Dodel, Richard (author)
- University Hospital Essen
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- Grossman, Murray (author)
- University of Pennsylvania
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- Kassubek, Jan (author)
- University of Ulm
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- Krismer, Florian (author)
- Medical University of Innsbruck
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- Levin, Johannes (author)
- World Orthopaedic Concern
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- Lorenzl, Stefan (author)
- Hospital Agatharied,German Center for Lung Research (DZL),Paracelsus Private Medical University of Salzburg
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- Morris, Huw (author)
- University College London
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- Nestor, Peter (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Oertel, Wolfgang H. (author)
- Philipp University of Marburg
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- Rabinovici, Gil D. (author)
- University of Texas Health Science Centre
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- Rowe, James B. (author)
- University of Cambridge
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- van Eimeren, Thilo (author)
- University Hospital of Cologne
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- Wenning, Gregor K. (author)
- Medical University of Innsbruck
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- Boxer, Adam (author)
- University of Texas Health Science Centre
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- Golbe, Lawrence I. (author)
- Rutgers Robert Wood Johnson Medical School
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- Litvan, Irene (author)
- University of California, San Diego
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- Stamelou, Maria (author)
- Attikon University Hospital,Hygeia Hospital,Philipp University of Marburg
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- Höglinger, Günter U. (author)
- Technical University of Munich,German Center for Neurodegenerative Diseases (DZNE), Bonn
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(creator_code:org_t)
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- 2017-05-13
- 2017
- English 11 s.
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In: Movement Disorders. - : Wiley. - 0885-3185. ; 32:7, s. 995-1005
- Related links:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Progressive supranuclear palsy (PSP) is a neuropathologically defined disease presenting with a broad spectrum of clinical phenotypes. Objective: To identify clinical features and investigations that predict or exclude PSP pathology during life, aiming at an optimization of the clinical diagnostic criteria for PSP. Methods: We performed a systematic review of the literature published since 1996 to identify clinical features and investigations that may predict or exclude PSP pathology. We then extracted standardized data from clinical charts of patients with pathologically diagnosed PSP and relevant disease controls and calculated the sensitivity, specificity, and positive predictive value of key clinical features for PSP in this cohort. Results: Of 4166 articles identified by the database inquiry, 269 met predefined standards. The literature review identified clinical features predictive of PSP, including features of the following 4 functional domains: ocular motor dysfunction, postural instability, akinesia, and cognitive dysfunction. No biomarker or genetic feature was found reliably validated to predict definite PSP. High-quality original natural history data were available from 206 patients with pathologically diagnosed PSP and from 231 pathologically diagnosed disease controls (54 corticobasal degeneration, 51 multiple system atrophy with predominant parkinsonism, 53 Parkinson's disease, 73 behavioral variant frontotemporal dementia). We identified clinical features that predicted PSP pathology, including phenotypes other than Richardson's syndrome, with varying sensitivity and specificity. Conclusions: Our results highlight the clinical variability of PSP and the high prevalence of phenotypes other than Richardson's syndrome. The features of variant phenotypes with high specificity and sensitivity should serve to optimize clinical diagnosis of PSP.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- clinical features
- clinico-pathological series
- diagnosis
- Progressive supranuclear palsy
- systematic review
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- for (subject category)
- ref (subject category)
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- By the author/editor
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Respondek, Gesin ...
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Kurz, Carolin
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Arzberger, Thoma ...
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Compta, Yaroslau
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Englund, Elisabe ...
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Ferguson, Leslie ...
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show more...
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Gelpi, Ellen
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Giese, Armin
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Irwin, David J.
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Meissner, Wassil ...
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Nilsson, Christe ...
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Pantelyat, Alexa ...
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Rajput, Alex
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van Swieten, Joh ...
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Troakes, Claire
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Josephs, Keith A ...
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Lang, Anthony E.
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Mollenhauer, Bri ...
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Müller, Ulrich
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Whitwell, Jennif ...
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Antonini, Angelo
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Bhatia, Kailash ...
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Bordelon, Yvette
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Corvol, Jean Chr ...
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Colosimo, Carlo
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Dodel, Richard
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Grossman, Murray
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Kassubek, Jan
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Krismer, Florian
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Levin, Johannes
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Lorenzl, Stefan
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Morris, Huw
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Nestor, Peter
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Oertel, Wolfgang ...
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Rabinovici, Gil ...
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Rowe, James B.
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van Eimeren, Thi ...
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Wenning, Gregor ...
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Boxer, Adam
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Golbe, Lawrence ...
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Litvan, Irene
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Stamelou, Maria
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Höglinger, Günte ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Movement Disorde ...
- By the university
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Lund University