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(WFRF:(Scott Laura J.)) pers:(Thorsteinsdottir Unnur)
 

Sökning: (WFRF:(Scott Laura J.)) pers:(Thorsteinsdottir Unnur) > (2010-2014) > Genetic evidence th...

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FältnamnIndikatorerMetadata
00005974naa a2200985 4500
001oai:lup.lub.lu.se:4eb8830c-976a-4e8d-b426-9faa9b2dba1f
003SwePub
008160401s2010 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/15336892 URI
0247 a https://doi.org/10.1093/hmg/ddp5222 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Perry, John R. B.4 aut
2451 0a Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes
264 c 2009-11-18
264 1b Oxford University Press (OUP),c 2010
520 a Epidemiological studies consistently show that circulating sex hormone binding globulin (SHBG) levels are lower in type 2 diabetes patients than non-diabetic individuals, but the causal nature of this association is controversial. Genetic studies can help dissect causal directions of epidemiological associations because genotypes are much less likely to be confounded, biased or influenced by disease processes. Using this Mendelian randomization principle, we selected a common single nucleotide polymorphism (SNP) near the SHBG gene, rs1799941, that is strongly associated with SHBG levels. We used data from this SNP, or closely correlated SNPs, in 27 657 type 2 diabetes patients and 58 481 controls from 15 studies. We then used data from additional studies to estimate the difference in SHBG levels between type 2 diabetes patients and controls. The SHBG SNP rs1799941 was associated with type 2 diabetes [odds ratio (OR) 0.94, 95% CI: 0.91, 0.97; P = 2 x 10(-5)], with the SHBG raising allele associated with reduced risk of type 2 diabetes. This effect was very similar to that expected (OR 0.92, 95% CI: 0.88, 0.96), given the SHBG-SNP versus SHBG levels association (SHBG levels are 0.2 standard deviations higher per copy of the A allele) and the SHBG levels versus type 2 diabetes association (SHBG levels are 0.23 standard deviations lower in type 2 diabetic patients compared to controls). Results were very similar in men and women. There was no evidence that this variant is associated with diabetes-related intermediate traits, including several measures of insulin secretion and resistance. Our results, together with those from another recent genetic study, strengthen evidence that SHBG and sex hormones are involved in the aetiology of type 2 diabetes.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
7001 a Weedon, Michael N.4 aut
7001 a Langenberg, Claudia4 aut
7001 a Jackson, Anne U.4 aut
7001 a Lyssenko, Valeriya4 aut
7001 a Sparso, Thomas4 aut
7001 a Thorleifsson, Gudmar4 aut
7001 a Grallert, Harald4 aut
7001 a Ferrucci, Luigi4 aut
7001 a Maggio, Marcello4 aut
7001 a Paolisso, Giuseppe4 aut
7001 a Walker, Mark4 aut
7001 a Palmer, Colin N. A.4 aut
7001 a Payne, Felicity4 aut
7001 a Young, Elizabeth4 aut
7001 a Herder, Christian4 aut
7001 a Narisu, Narisu4 aut
7001 a Morken, Mario A.4 aut
7001 a Bonnycastle, Lori L.4 aut
7001 a Owen, Katharine R.4 aut
7001 a Shields, Beverley4 aut
7001 a Knight, Beatrice4 aut
7001 a Bennett, Amanda4 aut
7001 a Groves, Christopher J.4 aut
7001 a Ruokonen, Aimo4 aut
7001 a Jarvelin, Marjo Riitta4 aut
7001 a Pearson, Ewan4 aut
7001 a Pascoe, Laura4 aut
7001 a Ferrannini, Ele4 aut
7001 a Bornstein, Stefan R.4 aut
7001 a Stringham, Heather M.4 aut
7001 a Scott, Laura J.4 aut
7001 a Kuusisto, Johanna4 aut
7001 a Nilsson, Peteru Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-pni
7001 a Neptin, Malinu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)infl-mne
7001 a Gjesing, Anette P.4 aut
7001 a Pisinger, Charlotta4 aut
7001 a Lauritzen, Torsten4 aut
7001 a Sandbaek, Annelli4 aut
7001 a Sampson, Mike4 aut
7001 a Magic, Ele Zeggini4 aut
7001 a Lindgren, Cecilia M.4 aut
7001 a Steinthorsdottir, Valgerdur4 aut
7001 a Thorsteinsdottir, Unnur4 aut
7001 a Hansen, Torben4 aut
7001 a Schwarz, Peter4 aut
7001 a Illig, Thomas4 aut
7001 a Laakso, Markku4 aut
7001 a Stefansson, Kari4 aut
7001 a Morris, Andrew D.4 aut
7001 a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
7001 a Pedersen, Oluf4 aut
7001 a Boehnke, Michael4 aut
7001 a Barroso, Ines4 aut
7001 a Wareham, Nicholas J.4 aut
7001 a Hattersley, Andrew T.4 aut
7001 a McCarthy, Mark I.4 aut
7001 a Frayling, Timothy M.4 aut
7102 a Internmedicin - epidemiologib Forskargrupper vid Lunds universitet4 org
7730 t Human Molecular Geneticsd : Oxford University Press (OUP)g 19:3, s. 535-544q 19:3<535-544x 0964-6906x 1460-2083
8564 u http://dx.doi.org/10.1093/hmg/ddp522y FULLTEXT
8564 u https://academic.oup.com/hmg/article-pdf/19/3/535/17251164/ddp522.pdf
8564 8u https://lup.lub.lu.se/record/1533689
8564 8u https://doi.org/10.1093/hmg/ddp522

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