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Positron emission t...
Positron emission tomography in clinical islet transplantation
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- Eriksson, Olof (author)
- Uppsala universitet,Enheten för radiologi
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- Eich, Torsten (author)
- Uppsala universitet,Enheten för klinisk immunologi,Korsgren
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- Sundin, Anders (author)
- Karolinska Institutet,Uppsala universitet,Enheten för radiologi
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- Tibell, Annika (author)
- Karolinska Institutet
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- Tufveson, Gunnar (author)
- Uppsala universitet,Transplantationskirurgi
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Andersson, H. (author)
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Felldin, M. (author)
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Foss, A. (author)
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Kyllönen, L. (author)
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- Långström, Bengt (author)
- Uppsala universitet,Institutionen för biokemi och organisk kemi
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- Nilsson, Bo (author)
- Uppsala universitet,Enheten för klinisk immunologi
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- Korsgren, Olle (author)
- Uppsala universitet,Enheten för klinisk immunologi
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- Lundgren, Torbjörn (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
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In: American Journal of Transplantation. - : Elsevier BV. - 1600-6135 .- 1600-6143. ; 9:12, s. 2816-2824
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The fate of islets in clinical transplantation is unclear. To elude on this positron emission tomography combined with computed tomography (PET/CT) was performed for 60 min during islet transplantation in five patients receiving six transplants. A fraction of the islets (23%) were labeled with 18F-fluorodeoxyglucose ([(18)F]FDG) and carefully mixed with unlabeled islets just prior to intraportal transplantation. The peak radioactivity concentration in the liver was found at 19 min after start of islet infusion and corresponded to only 75% of what was expected, indicating that islets are lost during the transplantation procedure. No accumulation of radioactivity was found in the lungs. A nonphysiological peak of C-peptide was found in plasma during and immediately after transplantation in all subjects. Distribution in the liver was heterogeneous with wide variations in location and concentration. Islets found in areas with concentrations of >400 IEQ/cc liver tissue varied between 1% and 32% of the graft in different subjects. No side effects attributed to the PET/CT procedure were found. Clinical outcome in all patients was comparable to that previously observed indicating that the [(18)F]FDG labeling procedure did not harm the islets. The technique has potential to be used to assess approaches to enhance islet survival and engraftment in clinical transplantation.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Eriksson, Olof
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Eich, Torsten
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Sundin, Anders
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Tibell, Annika
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Tufveson, Gunnar
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Andersson, H.
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Felldin, M.
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Foss, A.
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Kyllönen, L.
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Långström, Bengt
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Nilsson, Bo
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Korsgren, Olle
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Lundgren, Torbjö ...
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- Articles in the publication
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American Journal ...
- By the university
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Uppsala University
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Karolinska Institutet