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Association of Plat...
Association of Platelet Serotonin Levels in Alzheimers Disease with Clinical and Cerebrospinal Fluid Markers
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- Tajeddinn, Walid (author)
- Novum, Sweden
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- Fereshtehnejad, Seyed-Mohammad (author)
- Karolinska Institutet
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- Seed Ahmed, Mohammed (author)
- Novum, Sweden; Kings Coll London, England; University of Khartoum, Sudan
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- Yoshitake, Takashi (author)
- Karolinska Institutet
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- Kehr, Jan (author)
- Karolinska Institutet
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- Shahnaz, Tasmin (author)
- Novum, Sweden; Vrinnevi Hospital, Sweden
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- Milovanovic, Micha (author)
- Novum, Sweden; Vrinnevi Hospital, Sweden
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- Behbahani, Homira (author)
- Karolinska Institutet
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- Hoglund, Kina (author)
- Novum, Sweden; Gothenburg University, Sweden
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- Winblad, Bengt (author)
- Karolinska Institutet
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- Cedazo-Minguez, Angel (author)
- Karolinska Institutet
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- Jelic, Vesna (author)
- Karolinska Institutet
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- Jaremo, Petter (author)
- Novum, Sweden; Vrinnevi Hospital, Sweden
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- Aarsland, Dag (author)
- Karolinska Institutet
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(creator_code:org_t)
- IOS PRESS, 2016
- 2016
- English.
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In: Journal of Alzheimer's Disease. - : IOS PRESS. - 1387-2877 .- 1875-8908. ; 53:2, s. 621-630
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Subject headings
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- Introduction: Serotonin (5-HT) is involved in the pathology of Alzheimers disease (AD). Objective: We aimed to measure 5-HT level in platelets in AD and explore its association with cerebrospinal fluid (CSF), AD biomarkers (amyloid-beta 1-42 (A beta(42)), total tau (t-tau), and phosphorylated tau (p-tau)), and clinical symptoms. Methods: 15 patients with AD and 20 patients with subjective cognitive impairment (SCI) were included. 5-HT metabolites were measured, in a specific fraction, using high performance liquid chromatography with electrochemical detection (HPLC-ECD). Results: Significantly lower 5-HT concentrations were observed in AD patients compared to SCI patients both after normalization against total protein (p = 0.008) or platelet count (p = 0.019). SCI patients with lower 5-HT level have higher AD CSF biomarkers, total tau (p = 0.026) and tau/A beta(42) ratio (p = 0.001), compared to those with high 5-HT levels. Conclusion: AD patients have reduced platelet 5-HT levels. In SCI, lower 5-HT content was associated with a higher AD-CSF biomarker burden.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Alzheimers disease; amyloid; cognition; platelet; serotonin
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Tajeddinn, Walid
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Fereshtehnejad, ...
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Seed Ahmed, Moha ...
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Yoshitake, Takas ...
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Kehr, Jan
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Shahnaz, Tasmin
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Milovanovic, Mic ...
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Behbahani, Homir ...
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Hoglund, Kina
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Winblad, Bengt
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Cedazo-Minguez, ...
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Jelic, Vesna
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Jaremo, Petter
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Aarsland, Dag
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Journal of Alzhe ...
- By the university
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Linköping University
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Karolinska Institutet