Search: (swepub) lar1:(umu) pers:(Hernell Olle)
> (2010-2014) >
Noncontaminated die...
Noncontaminated dietary oats may hamper normalization of the intestinal immune status in childhood celiac disease
-
- Sjöberg, Veronika (author)
- Umeå universitet,Immunologi/immunkemi,Department of Clinical Microbiology, Immunology, Umeå University, Umeå, Sweden
-
- Hollén, Elisabet (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet
-
- Pietz, Grzegorz, 1983- (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Marie-Louise Hammarström,ology, Immunology, Umeå University, Umeå, Sweden
-
show more...
-
- Magnusson, Karl-Eric (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet
-
- Fälth-Magnusson, Karin (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping
-
- Sundström, Mia (author)
- Umeå universitet,Immunologi/immunkemi,Department of Clinical Microbiology, Immunology, Umeå University, Umeå, Sweden
-
- Holmgren Peterson, Kajsa (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet
-
- Sandström, Olof (author)
- Umeå universitet,Pediatrik,Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden
-
- Hernell, Olle (author)
- Umeå universitet,Pediatrik,Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden
-
- Hammarström, Sten, 1940- (author)
- Umeå universitet,Immunologi/immunkemi,Marie-Louise Hammarström,Department of Clinical Microbiology, Immunology, Umeå University, Umeå, Sweden
-
- Högberg, Lotta (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Barn- och ungdomskliniken i Norrköping
-
- Hammarström, Marie-Louise, 1951- (author)
- Umeå universitet,Immunologi/immunkemi,Marie-Louise Hammarström,Department of Clinical Microbiology, Immunology, Umeå University, Umeå, Sweden
-
show less...
-
(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2014
- 2014
- English.
-
In: Clinical and Translational Gastroenterology. - : Ovid Technologies (Wolters Kluwer Health). - 2155-384X. ; 5
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://umu.diva-por... (primary) (Raw object)
-
https://doi.org/10.1...
-
https://liu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- OBJECTIVES: Life-long, strict gluten-free diet (GFD) is the only treatment for celiac disease (CD). Because there is still uncertainty regarding the safety of oats for CD patients, the aim was to investigate whether dietary oats influence the immune status of their intestinal mucosa.METHODS: Paired small intestinal biopsies, before and after >11 months on a GFD, were collected from children with CD who were enrolled in a randomized, double-blind intervention trial to either of two diets: standard GFD (GFD-std; n=13) and noncontaminated oat-containing GFD (GFD-oats; n=15). Expression levels of mRNAs for 22 different immune effector molecules and tight junction proteins were determined by quantitative reverse transcriptase (RT)-PCR.RESULTS: The number of mRNAs that remained elevated was higher in the GFD-oats group (P=0.05). In particular, mRNAs for the regulatory T cell (Treg) signature molecules interleukin-10 (IL-10) and transforming growth factor-β1 (TGF-β1), the cytotoxicity-activating natural killer (NK) receptors KLRC2/NKG2C and KLRC3/NKG2E, and the tight junction protein claudin-4 remained elevated. Between the two groups, most significant differences were seen for claudin-4 (P=0.003) and KLRC3/NKG2E (P=0.04).CONCLUSIONS: A substantial fraction of pediatric CD patients seem to not tolerate oats. In these patients, dietary oats influence the immune status of the intestinal mucosa with an mRNA profile suggesting presence of activated cytotoxic lymphocytes and Tregs and a stressed epithelium with affected tight junctions. Assessment of changes in levels of mRNA for claudin-4 and KLC3/NKG2E from onset to after a year on oats containing GFD shows promise to identify these CD patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- immunologi
- Immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Sjöberg, Veronik ...
-
Hollén, Elisabet
-
Pietz, Grzegorz, ...
-
Magnusson, Karl- ...
-
Fälth-Magnusson, ...
-
Sundström, Mia
-
show more...
-
Holmgren Peterso ...
-
Sandström, Olof
-
Hernell, Olle
-
Hammarström, Ste ...
-
Högberg, Lotta
-
Hammarström, Mar ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Pediatrics
- Articles in the publication
-
Clinical and Tra ...
- By the university
-
Umeå University
-
Linköping University