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The Risk of Ovarian...
The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles : An Analysis from the Ovarian Cancer Cohort Consortium (OC3)
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- Trabert, Britton (author)
- NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
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- Tworoger, Shelley S. (author)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA
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- O'Brien, Katie M. (author)
- NIEHS, Epidemiol Branch, NIH, Durham, NC USA
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- Townsend, Mary K. (author)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA
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- Fortner, Renee T. (author)
- German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany
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- Iversen, Edwin S. (author)
- Duke Univ, Dept Stat Sci, Durham, NC USA
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- Hartge, Patricia (author)
- NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
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- White, Emily (author)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
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- Amiano, Pilar (author)
- BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, San Sebastian, Spain;CIBER Epidemiol & Salud Publ, Madrid, Spain
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- Arslan, Alan A. (author)
- NYU, Sch Med, NYU Langone Hlth, New York, NY USA;NYU, Perlmutter Canc Ctr, New York, NY USA,NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA,Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, Toronto, ON, Canada,Maastricht Univ, GROW Sch Oncol & Dev Biol, Maastricht, Netherlands
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- Bernstein, Leslie (author)
- City Hope Natl Med Ctr, Duarte, CA USA
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- Brinton, Louise A. (author)
- NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
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- Buring, Julie E. (author)
- Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
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- Dossus, Laure (author)
- IARC, Lyon, France
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- Fraser, Gary E. (author)
- Loma Linda Univ, Loma Linda, CA 92350 USA
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- Gaudet, Mia M. (author)
- Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA 30329 USA
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- Giles, Graham G. (author)
- Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia
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- Gram, Inger T. (author)
- Univ Tromso, Arctic Univ Norway, Dept Community Med, Tromso, Norway
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- Harris, Holly R. (author)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
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- Bolton, Judith Hoffman (author)
- Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA;Johns Hopkins Sch Med, Baltimore, MD USA
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- Idahl, Annika, 1965- (author)
- Umeå universitet,Obstetrik och gynekologi,Umea Univ, Dept Clin Sci Obstet & Gynecol, Umea, Sweden
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- Jones, Michael E. (author)
- Inst Canc Res, Div Genet & Epidemiol, London, England
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- Kaaks, Rudolf (author)
- German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany
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- Kirsh, Victoria A. (author)
- Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, Toronto, ON, Canada
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- Knutsen, Synnove F. (author)
- Loma Linda Univ, Loma Linda, CA 92350 USA
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- Kvaskoff, Marina (author)
- Univ Paris Saclay, Univ Paris Sud, UVSQ, INSERM,Fac Med,CESP, Villejuif, France;Gustave Roussy, Villejuif, France
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- Lacey, James, V (author)
- City Hope Natl Med Ctr, Duarte, CA USA
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- Lee, I-Min (author)
- Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
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- Milne, Roger L. (author)
- Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia
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- Onland-Moret, N. Charlotte (author)
- Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
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- Overvad, Kim (author)
- Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark
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- Patel, Alpa, V (author)
- Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA 30329 USA
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- Peters, Ulrike (author)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
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- Poynter, Jenny N. (author)
- Univ Minnesota, Div Pediat Epidemiol & Clin Res, Minneapolis, MN USA
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- Riboli, Elio (author)
- Imperial Coll London, Sch Publ Hlth, London, England
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- Robien, Kim (author)
- George Washington Univ, Milken Inst Sch Publ Hlth, Dept Exercise & Nutr Sci, Washington, DC USA
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- Rohan, Thomas E. (author)
- Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA
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- Sandler, Dale P. (author)
- NIEHS, Epidemiol Branch, NIH, Durham, NC USA
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- Schairer, Catherine (author)
- NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
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- Schouten, Leo J. (author)
- Maastricht Univ, GROW Sch Oncol & Dev Biol, Maastricht, Netherlands
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- Setiawan, Veronica W. (author)
- Univ Southern Calif, Los Angeles, CA 90007 USA
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- Swerdlow, Anthony J. (author)
- Inst Canc Res, Div Genet & Epidemiol, London, England;Inst Canc Res, Div Breast Canc Res, London, England
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- Travis, Ruth C. (author)
- Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England
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- Trichopoulou, Antonia (author)
- Hellen Hlth Fdn, Athens, Greece
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- van den Brandt, Piet A. (author)
- Maastricht Univ, GROW Sch Oncol & Dev Biol, Maastricht, Netherlands
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- Visvanathan, Kala (author)
- Univ Tromso, Arctic Univ Norway, Dept Community Med, Tromso, Norway
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- Wilkens, Lynne R. (author)
- Univ Hawaii, Populat Sci Pacific Program Canc Epidemiol, Canc Ctr, Honolulu, HI 96822 USA
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- Wolk, Alicja (author)
- Karolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Stockholm, Sweden
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- Zeleniuch-Jacquotte, Anne (author)
- NYU, Sch Med, NYU Langone Hlth, New York, NY USA;NYU, Perlmutter Canc Ctr, New York, NY USA
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- Wentzensen, Nicolas (author)
- NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
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(creator_code:org_t)
- AMER ASSOC CANCER RESEARCH, 2020
- 2020
- English.
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In: Cancer Research. - : AMER ASSOC CANCER RESEARCH. - 0008-5472 .- 1538-7445. ; 80:5, s. 1210-1218
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
Close
- Repeated exposure to the acute proinflammatory environment that follows ovulation at the ovarian surface and distal fallopian tube over a woman's reproductive years may increase ovarian cancer risk. To address this, analyses included individual-level data from 558,709 naturally menopausal women across 20 prospective cohorts, among whom 3,246 developed invasive epithelial ovarian cancer (2,045 serous, 319 endometrioid, 184 mucinous, 121 clear cell, 577 other/unknown). Cox models were used to estimate multivariable-adjusted HRs between lifetime ovulatory cycles (LOC) and its components and ovarian cancer risk overall and by histotype. Women in the 90th percentile of LOC (>514 cycles) were almost twice as likely to be diagnosed with ovarian cancer than women in the 10th percentile (<294) [HR (95% confidence interval): 1.92 (1.60-2.30)]. Risk increased 14% per 5-year increase in LOC (60 cycles) [(1.10-1.17)]; this association remained after adjustment for LOC components: number of pregnancies and oral contraceptive use [1.08 (1.04-1.12)]. The association varied by histotype, with increased risk of serous [1.13 (1.09-1.17)], endometrioid [1.20 (1.10-1.32)], and clear cell [1.37 (1.18-1.58)], but not mucinous [0.99 (0.88-1.10), P-heterogeneity = 0.01] tumors. Heterogeneity across histotypes was reduced [P-heterogeneity = 0.15] with adjustment for LOC components [1.08 serous, 1.11 endometrioid, 1.26 clear cell, 0.94 mucinous]. Although the 10-year absolute risk of ovarian cancer is small, it roughly doubles as the number of LOC rises from approximately 300 to 500. The consistency and linearity of effects strongly support the hypothesis that each ovulation leads to small increases in the risk of most ovarian cancers, a risk that cumulates through life, suggesting this as an important area for identifying intervention strategies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Trabert, Britton
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Tworoger, Shelle ...
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O'Brien, Katie M ...
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Townsend, Mary K ...
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Fortner, Renee T ...
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Iversen, Edwin S ...
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show more...
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Hartge, Patricia
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White, Emily
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Amiano, Pilar
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Arslan, Alan A.
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Bernstein, Lesli ...
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Brinton, Louise ...
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Buring, Julie E.
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Dossus, Laure
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Fraser, Gary E.
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Gaudet, Mia M.
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Giles, Graham G.
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Gram, Inger T.
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Harris, Holly R.
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Bolton, Judith H ...
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Idahl, Annika, 1 ...
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Jones, Michael E ...
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Kaaks, Rudolf
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Kirsh, Victoria ...
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Knutsen, Synnove ...
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Kvaskoff, Marina
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Lacey, James, V
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Lee, I-Min
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Milne, Roger L.
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Onland-Moret, N. ...
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Overvad, Kim
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Patel, Alpa, V
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Peters, Ulrike
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Poynter, Jenny N ...
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Riboli, Elio
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Robien, Kim
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Rohan, Thomas E.
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Sandler, Dale P.
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Schairer, Cather ...
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Schouten, Leo J.
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Setiawan, Veroni ...
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Swerdlow, Anthon ...
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Travis, Ruth C.
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Trichopoulou, An ...
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van den Brandt, ...
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Visvanathan, Kal ...
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Wilkens, Lynne R ...
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Wolk, Alicja
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Zeleniuch-Jacquo ...
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Wentzensen, Nico ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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- Articles in the publication
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Cancer Research
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Uppsala University
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Umeå University
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Karolinska Institutet