IL-1beta, IL-6, TNFalpha, fetal fibronectin, and endotoxin in the lower genital tract of pregnant women with bacterial vaginosis.

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Fältnamn	Indikatorer	Metadata
000		05555naa a2200817 4500
001		oai:gup.ub.gu.se/289842
003		SwePub
008		240528s1998 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/2898422 URI
024	7	a https://doi.org/10.1034/j.1600-0412.1998.770701.x2 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Mattsby-Baltzer, Inger,d 1949u Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk bakteriologi,Institute of Laboratory Medicine, Dept of Clinical Bacteriology4 aut0 (Swepub:gu)xmatin
245	1 0	a IL-1beta, IL-6, TNFalpha, fetal fibronectin, and endotoxin in the lower genital tract of pregnant women with bacterial vaginosis.
264		c 2003-06-11
264	1	b Wiley,c 1998
520		a In our studies on women with bacterial vaginosis (BV) in early pregnancy a strong association has been found between BV and the levels of endotoxin or interleukin-1alpha (IL-1alpha) in the lower genital tract. In the present study we investigated if an association could be found between BV and other cytokines (IL-1beta, IL-6, tumor necrosis factor alpha, TNF) or fetal fibronectin (FFN). The cytokine-inducing capacity of endotoxins present in the cervical mucus was explored in a monocytic cell assay.Cervical mucus or cervicovaginal fluid was collected from women with (BV) and without BV (nonBV) attending a family planning unit for first trimester abortion. The concentrations of IL-1beta, IL-6, TNF and FFN were determined by quantitative enzyme immunoassays. TNF was determined in 63 women (BV, n=25) out of whom 37 (BV, n=11) were analyzed for IL-1beta and the remaining 26 for IL-6 (BV, n=14). FFN was determined in another 36 women (BV, n= 19). The cytokine-inducing capacity of endotoxin-containing cervical mucus and purified endotoxin of Prevotella bivia were studied by an in vitro cell assay using a human monocytic cell line (THP-1).IL-lbeta and IL-6 were found in almost all women. The levels of IL-1beta, but not IL-6, TNF or FFN, were significantly increased in women with BV compared with the nonBV women (p<0.05). Purified endotoxin from P. bivia, and cervical mucus from BV women containing high levels of endotoxin were able to induce a cytokine response (IL-6) in monocytic cells in vitro.BV is associated with increased levels of IL-1beta in the lower genital tract of pregnant women in the first trimester. The ability of BV-associated endotoxins to induce cytokine production in monocytic cells may partly explain the increased IL-1beta levels.
650	7	a NATURVETENSKAPx Biologix Immunologi0 (SwePub)106052 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Immunology0 (SwePub)106052 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
653		a Adult
653		a Bacteroidaceae Infections
653		a immunology
653		a metabolism
653		a microbiology
653		a Cervix Mucus
653		a metabolism
653		a Endotoxins
653		a metabolism
653		a Female
653		a Fibronectins
653		a metabolism
653		a Genitalia
653		a Female
653		a immunology
653		a metabolism
653		a microbiology
653		a Humans
653		a Interleukin-1
653		a metabolism
653		a Interleukin-6
653		a metabolism
653		a Pregnancy
653		a Pregnancy Complications
653		a Infectious
653		a immunology
653		a metabolism
653		a microbiology
653		a Pregnancy Trimester
653		a First
653		a Prevotella
653		a Tumor Necrosis Factor-alpha
653		a metabolism
653		a Vaginosis
653		a Bacterial
653		a immunology
653		a metabolism
653		a microbiology
700	1	a Platz-Christensen, Jens Jörgenu Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för obstetrik och gynekologi,Institute for the Health of Women and Children, Dept of Obstetrics and Gynaecology4 aut
700	1	a Hosseini Johnsson, Nosrat,d 1953u Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk bakteriologi,Institute of Laboratory Medicine, Dept of Clinical Bacteriology4 aut0 (Swepub:gu)xhosno
700	1	a Rosén, Petrau Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk bakteriologi,Institute of Laboratory Medicine, Dept of Clinical Bacteriology4 aut
710	2	a Göteborgs universitetb Institutionen för laboratoriemedicin, Avdelningen för klinisk bakteriologi4 org
773	0	t Acta obstetricia et gynecologica Scandinavicad : Wileyg 77:7, s. 701-6q 77:7<701-6x 0001-6349
856	4 8	u https://gup.ub.gu.se/publication/289842
856	4 8	u https://doi.org/10.1034/j.1600-0412.1998.770701.x

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