L773:0079 6123 OR L773:1875 7855 OR L773:9780444642608
Sökning: L773:0079 6123 OR L773:1875 7855 OR L773:9780444642608 > (2005-2009) > Nanoparticles influ...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03122naa a2200397 4500 | |
| 001 | oai:DiVA.org:uu-137717 | |
| 003 | SwePub | |
| 008 | 101215s2009 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1377172 URI |
| 024 | 7 | a https://doi.org/10.1016/S0079-6123(08)80009-X2 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a for2 swepub-publicationtype |
| 100 | 1 | a Sharma, Hari Shankeru Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)hssharma |
| 245 | 1 0 | a Nanoparticles influence pathophysiology of spinal cord injury and repair |
| 264 | 1 | a Amsterdam :b Elsevier,c 2009 |
| 338 | a print2 rdacarrier | |
| 520 | a Spinal cord injury (SCI) is a serious clinical problem for which no suitable therapeutic strategies have been worked out so far. Recent studies suggest that the SCI and its pathophysiological responses could be altered by systemic exposure to nanoparticles. Thus, SCI when made in animals intoxicated with engineered nanoparticles from metals or silica dust worsened the outcome. On the other hand, drugs tagged with titanium (TiO2) nanoparticles or encapsulated in liposomes could enhance their neuroprotective efficacy following SCI. Thus, to expand our knowledge on nanoparticle-induced alterations in the spinal cord pathophysiology further research is needed. These investigations will help to develop new strategies to achieve neuroprotection in SCI, for example, using nanodrug delivery. New results from our laboratory showed that nanoparticle-induced exacerbation of cord pathology following trauma can be reduced when the suitable drugs tagged with TiO2 nanowires were administered into the spinal cord as compared to those drugs given alone. This indicates that nanoparticles depending on the exposure and its usage could induce both neurotoxicity and neuroprotection. This review discusses the potential adverse or therapeutic utilities of nanoparticles in SCI largely based on our own investigations. In addition, possible mechanisms of nanoparticle-induced exacerbation of cord pathology or enhanced neuroprotection following nanodrug delivery is described in light of recently available data in this rapidly emerging field of nanoneurosciences. | |
| 653 | a nanoparticles | |
| 653 | a spinal cord injury | |
| 653 | a nanodrug delivery | |
| 653 | a blood-spinal cord barrier | |
| 653 | a spinal cord edema | |
| 653 | a cord pathology | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Muresanu, Dafin F.4 aut |
| 700 | 1 | a Sharma, Arunau Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)arush975 |
| 700 | 1 | a Patnaik, Ranjana4 aut |
| 700 | 1 | a Vicente Lafuente, Jose4 aut |
| 710 | 2 | a Uppsala universitetb Anestesiologi och intensivvård4 org |
| 773 | 0 | t Progress in Brain Researchd Amsterdam : Elsevierg 180, s. 155-180q 180<155-180x 0079-6123x 1875-7855z 9780444534316 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-137717 |
| 856 | 4 8 | u https://doi.org/10.1016/S0079-6123(08)80009-X |
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