Sökning: L773:0918 6158 OR L773:1347 5215 >
Evaluation of the C...
Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa
-
- Ruhaak, Lucia Renee (författare)
- Uppsala universitet,Avdelningen för farmakognosi
-
- Felth, Jenny (författare)
- Uppsala universitet,Avdelningen för farmakognosi
-
Karlsson, Pernilla Christina (författare)
-
visa fler...
-
- Rafter, Joseph James (författare)
- Karolinska Institutet
-
Verpoorte, Robert (författare)
-
- Bohlin, Lars (författare)
- Uppsala universitet,Avdelningen för farmakognosi
-
visa färre...
-
(creator_code:org_t)
- Pharmaceutical Society of Japan, 2011
- 2011
- Engelska.
-
Ingår i: Biological and Pharmaceutical Bulletin. - : Pharmaceutical Society of Japan. - 0918-6158 .- 1347-5215. ; 34:5, s. 774-778
- Relaterad länk:
-
https://www.jstage.j...
-
visa fler...
-
https://urn.kb.se/re...
-
http://kipublication...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Cyclooxygenase enzymes (COX-1 and COX-2) catalyse the production of prostaglandins from arachidonic acid. Prostaglandins are important mediators in the inflammatory process and their production can be reduced by COX-inhibitors. Endocannabinoids, endogenous analogues of the plant derived cannabinoids, occur normally in the human body. The Endocannabinoids are structurally similar to arachidonic acid and have been suggested to interfere with the inflammatory process. They have also been shown to inhibit cancer cell proliferation. Anti-inflammatory effects of cannabinoids and endocannabinoids have been observed, however the mode of action is not yet clarified. Anti-inflammatory activity (i.e., inhibition of COX-2) is proposed to play an important role in the development of colon cancer, which makes this subject interesting to study further. In the present work, the six cannabinoids tetrahydrocannabinol (Delta(9)-THC), tetrahydrocannabinolic acid (Delta(9)-THC-A), cannabidiol (CBD), cannabidiolic acid (CBDA), cannabigerol (CBG) and cannabigerolic acid (CBGA), isolated from Cannabis sativa, were evaluated for their effects on prostaglandin production. For this purpose an in vitro enzyme based COX-1/COX-2 inhibition assay and a cell based prostaglandin production radioimmunoassay were used. Cannabinoids inhibited cyclooxygenase enzyme activity with IC50 values ranging from 1.7.10(-3) to 2.0.10(-4) M.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- cannabinoid
- cyclooxygenase inhibition
- prostaglandin production
- PHARMACY
- FARMACI
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas