Nearest neighbor analysis of dopamine D1 receptors and Na plus -K plus -ATPases in dendritic spines dissected by STED microscopy

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Fältnamn	Indikatorer	Metadata
000		03030naa a2200433 4500
001		oai:DiVA.org:kth-50744
003		SwePub
008		111207s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-507442 URI
024	7	a https://doi.org/10.1002/jemt.210462 DOI
040		a (SwePub)kth
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Blom, Hansu KTH,Experimentell biomolekylär fysik4 aut0 (Swepub:kth)u1qhk3ta
245	1 0	a Nearest neighbor analysis of dopamine D1 receptors and Na plus -K plus -ATPases in dendritic spines dissected by STED microscopy
264		c 2011-08-01
264	1	b Wiley,c 2012
338		a print2 rdacarrier
500		a QC 20120309
520		a Protein localization in dendritic spines is the focus of intense investigations within neuroscience. Applications of super-resolution microscopy to dissect nanoscale protein distributions, as shown in this work with dual-color STED, generate spatial correlation coefficients having quite small values. This means that colocalization analysis to some extent looses part of its correlative impact. In this study we thus introduced nearest neighbor analysis to quantify the spatial relations between two important proteins in neurons, the dopamine D1 receptor and Na+,K+-ATPase. The analysis gave new information on how dense the D1 receptor and Na+,K+-ATPase constituting nanoclusters are located both with respect to the homogenous (self to same) and the heterogeneous (same to other) topology. The STED dissected nanoscale topologies provide evidence for both a joint as well as a separated confinement of the D1 receptor and the Na+,K+-ATPase in the postsynaptic areas of dendritic spines. This confined topology may have implications for generation of local sodium gradients and for structural and functional interactions modulating slow synaptic transmission processes. Microsc. Res. Tech., 2011.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologi0 (SwePub)3042 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Medical Biotechnology0 (SwePub)3042 hsv//eng
653		a fluorescence microscopy
653		a STED
653		a localization
653		a striatal neurons
700	1	a Rönnlund, Danielu KTH,Experimentell biomolekylär fysik4 aut0 (Swepub:kth)u1vmbh2t
700	1	a Scott, Lena4 aut
700	1	a Spicarova, Zuzana4 aut
700	1	a Rantanen, Ville4 aut
700	1	a Widengren, Jerkeru KTH,Experimentell biomolekylär fysik4 aut0 (Swepub:kth)u1i3g09c
700	1	a Aperia, Anita4 aut
700	1	a Brismar, Hjalmaru KTH,Cellens fysik4 aut0 (Swepub:kth)u1232ew5
710	2	a KTHb Experimentell biomolekylär fysik4 org
773	0	t Microscopy research and technique (Print)d : Wileyg 75:2, s. 220-228q 75:2<220-228x 1059-910Xx 1097-0029
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-50744
856	4 8	u https://doi.org/10.1002/jemt.21046

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Av författaren/redakt...: Blom, Hans; Rönnlund, Daniel; Scott, Lena; Spicarova, Zuzan ...; Rantanen, Ville; Widengren, Jerke ...; visa fler...; Aperia, Anita; Brismar, Hjalmar; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinsk biotek ...

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Av lärosätet: Kungliga Tekniska Högskolan

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