Large fat and skin necroses after deep subcutaneous injections of a slow-release somatostatin analogue in a woman with acromegaly.

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Fältnamn	Indikatorer	Metadata
000		03180naa a2200313 4500
001		oai:lup.lub.lu.se:0f848d03-e6f2-43d8-aff2-cefe48e75334
003		SwePub
008		160404s2010 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/17320642 URI
024	7	a https://doi.org/10.1016/j.ghir.2010.10.0042 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Burman, Piau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-bap
245	1 0	a Large fat and skin necroses after deep subcutaneous injections of a slow-release somatostatin analogue in a woman with acromegaly.
264	1	b Elsevier BV,c 2010
520		a OBJECTIVE: Somatostatin analogues are the most commonly used drugs for treatment of acromegaly. Known side effects include gastrointestinal reactions, cholelithiasis, effects on glucose metabolism, and mild reactions at injection sites. We report a patient who developed fat and skin necroses after injections of a depot somatostatin analogue. SUBJECT: A woman with active acromegaly was given deep subcutaneous injections of an extended release formulation of lanreotide at alternate sides of the buttocks on three occasions over a ten week period. The regimen was then discontinued due to gastrointestinal complaints. One month later indurated subcutaneous nodules appeared at both sites. After another two months, the patient presented 10×10cm lesions on the buttocks, with central erythematous zones and, at the site of two injections, a necrotic 5×3cm ulcer. There were no signs of infection or systemic diseases. MRI revealed bilateral fat necroses. A month later, an ulcer developed at the second site. The ulcers were managed conservatively until clear demarcations were obtained, where after surgical revisions were performed. Eight months after the last injection, the wounds could be closed. CONCLUSION: The fat and skin necroses represent a side-effect not previously described after deep subcutaneous injections. Possibly, the patient had an exceptional susceptibility to develop an inflammatory, foreign-body like reaction that hypothetically was aggravated by a sustained anti-angiogenic effect of the compound.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
700	1	a Besjakov, Jan4 aut
700	1	a Svensjö, Tore4 aut
710	2	a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org
773	0	t Growth Hormone & Igf Researchd : Elsevier BVg Dec, s. 438-440q Dec<438-440x 1532-2238x 1096-6374
856	4	u http://www.ncbi.nlm.nih.gov/pubmed/21071248?dopt=Abstracty FULLTEXT
856	4	u http://dx.doi.org/10.1016/j.ghir.2010.10.004y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/1732064
856	4 8	u https://doi.org/10.1016/j.ghir.2010.10.004

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Av författaren/redakt...: Burman, Pia; Besjakov, Jan; Svensjö, Tore

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