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Predictive characte...
Predictive characteristics for disease recurrence and overall survival in non-metastatic clinical T1 renal cell carcinoma : results from the National Swedish Kidney Cancer Register
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- Almdalal, Tarik (author)
- Department of Surgery and Urology, Eskilstuna Country Hospital, Eskilstuna, Sweden
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- Rosenblad, Andreas, Fil. dr, docent, 1973- (author)
- Karolinska Institutet,Uppsala universitet,Klinisk diabetologi och metabolism,Regional Cancer Centre Stockholm-Gotland, Stockholm, Sweden; Department of Medical Sciences, Division of Clinical Diabetology and Metabolism, Uppsala University, Uppsala, Sweden; Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institutet, Solna, Sweden
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- Hellström, Mikael, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology
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- Kjellman, Anders (author)
- Karolinska Institutet
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- Lindblad, Per, 1953- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Lundstam, Sven, 1944 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Oncology,Institute of Clinical Sciences, Department of Urology
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- Sundqvist, Pernilla, 1973- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Ljungberg, Börje, Professor, 1949- (author)
- Umeå universitet,Urologi och andrologi,Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden
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(creator_code:org_t)
- 2022-12-15
- 2023
- English.
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In: Scandinavian journal of urology. - : Taylor & Francis. - 2168-1805 .- 2168-1813. ; 57:1-6, s. 67-74
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Abstract
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- ObjectivePatients with clinical T1 renal cell carcinoma (cT1RCC) have risks for recurrence and reduced overall survival despite being in the best prognostic group. This study aimed to evaluate the association of different treatments on disease recurrence and overall survival using clinical and pathological characteristics in a nation-wide cT1RCC cohort.Materials and methodsA total of 4,965 patients, registered in the National Swedish Kidney Cancer Register (NSKCR) between 2005 and 2014, with ≥ 5-years follow-up were identified: 3,040 males and 1,925 females, mean age 65 years. Times to recurrence and overall survival were analyzed with Kaplan-Meier curves, log-rank test, and Cox regression models.ResultsAge, TNM-stage, tumor size, RCC-type, and performed treatment were all associated with disease recurrence. Patients selected for ablative treatments had increased risk for recurrent disease: hazard ratio (HR) = 3.79 [95% confidence interval (CI) = 2.69–5.32]. In multivariate analyses, age, gender, tumor size, RCC-type, N-stage, recurrence and performed treatment were all independently associated with overall survival. Patients with chRCC had a 41% better overall survival (HR = 0.59, 95% CI = 0.44–0.78; p < 0.001) than ccRCC. Patients treated with partial nephrectomy (PN) had an 18% better overall survival (HR = 0.83, 95% CI = 0.71–0.95, p < 0.001) than patients treated with radical nephrectomy.ConclusionsAge, gender, T-stage, tumor size, RCC type and treatment modality are all associated with risk of recurrence. Furthermore, age, male gender, tumor size, N-stage and recurrence are associated with reduced overall survival. Patients with chRCC, compared with ccRCC and pRCC patients, and PN compared with RN treated patients, had an advantageous overall survival, indicating a possible survival advantage of nephron sparing treatment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Radical nephrectomy
- partial nephrectomy
- renal cell carcinoma
- T-stage
- TNM stage
- radiofrequency ablation
- cryoablation
- tumor size
- RCC type
- tumor recurrence
- overall survival
- Oncology
- Onkologi
- radical nephrectomy
- partial nephrectomy
- radiofrequency ablation
- tumor recurrence
- survival
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Almdalal, Tarik
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Rosenblad, Andre ...
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Hellström, Mikae ...
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Kjellman, Anders
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Lindblad, Per, 1 ...
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Lundstam, Sven, ...
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Sundqvist, Perni ...
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Ljungberg, Börje ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Scandinavian jou ...
- By the university
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Uppsala University
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Örebro University
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Umeå University
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Karolinska Institutet
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University of Gothenburg