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Telomerase inhibito...
Telomerase inhibitors and activators in aging and cancer : A systematic review
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- Fragkiadaki, Persefoni (författare)
- Univ crete, Med Sch, Lab Toxicol, Iraklion 71003, Greece.;Spin off Toxplus SA, Iraklion 71601, Greece.
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- Renieri, Elisavet (författare)
- Univ crete, Med Sch, Lab Toxicol, Iraklion 71003, Greece.
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- Kalliantasi, Katerina (författare)
- Univ crete, Med Sch, Lab Toxicol, Iraklion 71003, Greece.
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- Kouvidi, Elisavet (författare)
- Genet Diag Clin Genet & Res, Genesis Genoma Lab, Athens 15232, Greece.
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- Apalaki, Evita (författare)
- Uppsala universitet,Medicinsk genetik och genomik
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- Vakonaki, Elena (författare)
- Univ crete, Med Sch, Lab Toxicol, Iraklion 71003, Greece.;Spin off Toxplus SA, Iraklion 71601, Greece.
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- Mamoulakis, Charalampos (författare)
- Univ Crete, Univ Gen Hosp Heraklion, Dept Urol, Iraklion, Greece.
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- Spandidos, Demetrios A. (författare)
- Univ Crete, Sch Med, Lab Clin Virol, Iraklion 71003, Greece.
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- Tsatsakis, Aristidis (författare)
- Univ crete, Med Sch, Lab Toxicol, Iraklion 71003, Greece.;Spin off Toxplus SA, Iraklion 71601, Greece.
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Univ crete, Med Sch, Lab Toxicol, Iraklion 71003, Greece;Spin off Toxplus SA, Iraklion 71601, Greece. Univ crete, Med Sch, Lab Toxicol, Iraklion 71003, Greece. (creator_code:org_t)
- 2022-03-08
- 2022
- Engelska.
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Ingår i: Molecular Medicine Reports. - : Spandidos Publications. - 1791-2997 .- 1791-3004. ; 25:5
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- The main aim of the present systematic review was to summarize the most frequently used telomerase regulators with an impact on aging and cancer that are referred to in in vitro and in vivo studies. For this purpose, a systematic review of the available literature on telomerase regulators referred to in articles from PubMed and Scopus libraries published from 2002 to 2021 and in accordance with PRISMA 2020 criteria, was conducted. Articles were included if they met the following criteria: They referred to telomerase modulators in aging and in cancer and were in vitro and/or in vivo studies, while studies that did not provide sufficient data or studies not written in English were excluded. In the present systematic review, 54 publications were included, of which 29 were full-text published studies, 11 were full-text reviews, 10 structure-based design studies and 4 abstracts are reported in this review. Telomerase regulators were then categorized as synthetic direct telomerase inhibitors, synthetic indirect telomerase inhibitors, synthetic telomerase activators, natural direct telomerase activators, natural telomerase inhibitors and natural indirect telomerase activators, according to their origin and their activity. On the whole, as demonstrated herein, telomerase regulators appear to be promising treatment agents in various age-related diseases. However, further in vivo and in vitro studies need to be performed in order to clarify the potentiality of telomerase as a therapeutic target.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- telomerase enzyme
- inhibitors
- activators
- telomere length
- regulators
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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