Modulation of Alzheimer's amyloid β peptide self-assembly: Insights into molecular mechanisms of peptide aggregation associated with Alzheimer's disease

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Abelein, Axel,1985-Stockholms universitet,Institutionen för biokemi och biofysik (författare)

Modulation of Alzheimer's amyloid β peptide self-assembly : Insights into molecular mechanisms of peptide aggregation associated with Alzheimer's disease

BokEngelska2015

Förlag, utgivningsår, omfång ...

Stockholm :Department of Biochemistry and Biophysics, Stockholm University,2015
49 s.
electronicrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:su-114172
ISBN:9789176491041
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-114172URI

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Språk:engelska
Sammanfattning på:engelska

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At the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 4: Manuscript.
Misfolding of proteins and peptides is closely linked to several neurodegenerative disorders, among them Alzheimer's disease (AD), the most prominent example of brain diseases. The self-assembly of the amyloid β peptide (Aβ) into amyloid fibrils is one histologic hallmark of AD. A detailed knowledge about the underlying mechanism(s) of Aβ aggregation is crucial for advances toward a fundamental understanding of the disease, which may promote the search for and design of efficient therapeutics. The work presented in this thesis deals with modulation of the aggregation process by various compounds, i.e. small organic molecules (e.g. lacmoid and Congo red), surfactants and metal ions. These results provide insight into the molecular mechanism of modulator interactions and interference with Aβ and its aggregation pathways. Applying a combination of kinetic and dynamic studies as well as structural investigations we characterized the molecular interactions between Aβ and aggregation modulators in terms of microscopic rate constants, conformational preferences and thermodynamics. An important conclusion is that these modulators form highly dynamic complexes with Aβ, with life-times on the timescale of milliseconds. Despite the similar exchange dynamics, the effect on peptide aggregation is modulator-specific and fibril formation can be accelerated, retarded or inhibited by their interactions. In summary, Aβ self-assembly is governed by microscopic kinetic and dynamic processes that can be altered by aggregation modulators. Further elucidation of these mechanisms is beneficial for the understanding and therapeutic intervention of amyloid diseases.

Ämnesord och genrebeteckningar

NATURVETENSKAP Biologi Biofysik hsv//swe
NATURAL SCIENCES Biological Sciences Biophysics hsv//eng
Biophysics
biofysik

Biuppslag (personer, institutioner, konferenser, titlar ...)

Gräslund, Astrid,Prof.Stockholms universitet,Institutionen för biokemi och biofysik (preses)
Bax, Adriaan,Prof.National Institutes of Health (opponent)
Stockholms universitetInstitutionen för biokemi och biofysik (creator_code:org_t)

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Av författaren/redakt...: Abelein, Axel, 1 ...; Gräslund, Astrid ...; Bax, Adriaan, Pr ...

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NATURVETENSKAP: NATURVETENSKAP; och Biologi; och Biofysik

Av lärosätet: Stockholms universitet

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