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FältnamnIndikatorerMetadata
00010268naa a2200937 4500
001oai:gup.ub.gu.se/309865
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008240528s2022 | |||||||||||000 ||eng|
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0247 a https://gup.ub.gu.se/publication/3098652 URI
0247 a https://doi.org/10.1111/cen.146222 DOI
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040 a (SwePub)gud (SwePub)orud (SwePub)umud (SwePub)liud (SwePub)kid (SwePub)uud (SwePub)lu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Petersson, M.u Karolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Endocrinol, SE-17176 Stockholm, Sweden.,Karolinska University Hospital4 aut
2451 0a Natural history and surgical outcome of Rathke's cleft cysts-A study from the Swedish Pituitary Registry
264 c 2021-11
264 1b Wiley,c 2022
520 a Objective Rathke's cleft cysts are benign, embryological remnants in the pituitary gland. The majority of them are small and asymptomatic but a few may become large, and cause mass effects, pituitary hormone deficiencies and visual impairment. Recommendations for the follow-up of Rathke's cleft cysts vary since data on the natural history are sparse. Patients and Design Data at diagnosis and at 1, 5 and 10 years for patients with a Rathke's cleft cyst (434 at diagnosis, 317 females) were retrieved from the Swedish Pituitary Registry. Cysts <= 3 mm in diameter were excluded from the study. Measurements Data included demographics, cyst size, pituitary function, visual defects and surgery. Results The mean age at diagnosis was 45 years. In patients with cysts <10 mm in diameter (n = 204) 2.9% had pituitary hormone deficiencies and 2% had visual field impairments. Cyst size did not progress during the 5 years. Cysts with a diameter of >= 10 mm that were not operated (n = 174) decreased in size over the years (p < .01). Pituitary hormone deficiencies and visual impairments were more frequent (18% and 5.7%, respectively) but were stable over time. Transphenoidal surgery was performed in 56 patients of whom 51 underwent surgery before the 1-year follow-up. The mean cyst diameter at diagnosis was 18 mm (range: 930 mm), 36% had pituitary hormone deficiency, 45% had visual field defects and 20% had impaired visual acuity. One year after surgery 60% had no cyst remnants, 50% had a pituitary deficiency, 26% had visual field defects and 12% had impaired visual acuity. No major changes were observed after 5 years. Twelve of the operated patients had a follow-up at 10 years, in eight the cyst remnants or recurrences increased in size over time (p < .05). Conclusions Rathke's cleft cysts with a size less than 10 mm rarely grow and our results indicate that radiological follow-up can be restricted to 5 years. In contrast, progression of postoperative remnants or recurrent cysts is more likely and require long-term follow-up.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
653 a cyst size
653 a hypopituitarism
653 a pituitary
653 a Rathke's cleft cyst
653 a transphenoidal surgery
653 a visual impairment
653 a ciliated craniopharyngioma
653 a clinical-features
653 a management
653 a surgery
653 a lesions
653 a Endocrinology & Metabolism
653 a Rathke's cleft cyst
7001 a Berinder, K.u Karolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Endocrinol, SE-17176 Stockholm, Sweden.,Karolinska University Hospital4 aut
7001 a Ekman, Bertil,d 1958-u Linköping University,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken,Linköping Univ, Dept Endocrinol Linköping, Linköping, Sweden.;Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.4 aut0 (Swepub:liu)berek83
7001 a Tsatsaris, Erikau Uppsala universitet,Endokrinologi och mineralmetabolism,Uppsala University Hospital4 aut0 (Swepub:uu)erits420
7001 a Ekman, B.4 aut
7001 a Wahlberg, Jeanette,d 1969-u Örebro University,Linköping University,Linköpings universitet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Endocrinology in Linköping and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden; Department of Internal Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken,Linköping Univ, Dept Endocrinol Linköping, Linköping, Sweden.;Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.;Örebro Univ, Sch Hlth & Med Sci, Dept Internal Med, Örebro, Sweden.4 aut0 (Swepub:liu)jeawa98
7001 a Burman, Piau Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-bap
7001 a Borg, Henriku Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)he1116bo
7001 a Siesjö, Peteru Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital4 aut0 (Swepub:lu)nkir-psi
7001 a Dahlqvist, Peru Umeå University,Umeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden.4 aut0 (Swepub:umu)perdat96
7001 a Akerman, A. K.u Örebro University,Karolinska Institutet,Örebro Univ, Sch Hlth & Med Sci, Dept Internal Med, Örebro, Sweden.4 aut
7001 a Ragnarsson, Oskar,d 1971u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Inst Med Sahlgrenska Acad, Dept Internal Med & Clin Nutr, Gothenburg, Sweden.4 aut0 (Swepub:gu)xragos
7001 a Olsson, M.u Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Dept Neurosurg, Stockholm, Sweden.4 aut
7001 a Forander, P.u Karolinska Institutet,Karolinska Univ Hosp, Dept Neurosurg, Stockholm, Sweden.,Karolinska University Hospital4 aut
7001 a Bensing, S.u Karolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Endocrinol, SE-17176 Stockholm, Sweden.,Karolinska University Hospital4 aut
7001 a Hoybye, C.u Karolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Endocrinol, SE-17176 Stockholm, Sweden.,Karolinska University Hospital4 aut
7001 a Edén Engström, Brittu Uppsala universitet,Endokrinologi och mineralmetabolism,Uppsala University Hospital4 aut0 (Swepub:uu)brittee
7102 a Karolinska Institutetb Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Endocrinol, SE-17176 Stockholm, Sweden.4 org
7730 t Clinical Endocrinologyd : Wileyg 96:1, s. 54-61q 96:1<54-61x 0300-0664x 1365-2265
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cen.14622
8564 u https://doi.org/10.1111/cen.14622y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1612797/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print
8564 u https://liu.diva-portal.org/smash/get/diva2:1613505/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://uu.diva-portal.org/smash/get/diva2:1641516/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u http://dx.doi.org/10.1111/cen.14622x freey FULLTEXT
8564 8u https://gup.ub.gu.se/publication/309865
8564 8u https://doi.org/10.1111/cen.14622
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-95304
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-189568
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-181197
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:148071507
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-468881
8564 8u https://lup.lub.lu.se/record/6ecdaf06-024a-4876-8d63-d08a1262029e

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