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Cancer-related chan...
Cancer-related changes and low-to-moderate exposure to welding fumes : A longitudinal study
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- Dauter, Ulrike Maria (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Inst Environm Med, Nobels Vag 13, S-17177 Stockholm, Sweden.
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- Alhamdow, Ayman (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Inst Environm Med, Nobels Vag 13, S-17177 Stockholm, Sweden.
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- Cediel-Ulloa, Andrea (författare)
- Uppsala University,Karolinska Institute,Uppsala universitet,Fysiologi och miljötoxikologi,Karolinska Inst, Inst Environm Med, Nobels Vag 13, S-17177 Stockholm, Sweden
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- Gliga, Anda Roxana (författare)
- Karolinska Institute
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- Albin, Maria (författare)
- Karolinska Institute,Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Miljöepidemiologi,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Environmental Epidemiology,Lund University Research Groups
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- Broberg, Karin (författare)
- Karolinska Institute,Lund University,Lunds universitet,Karolinska Institutet,Karolinska Inst, Inst Environm Med, Nobels Vag 13, S-17177 Stockholm, Sweden.;Lund Univ, Div Occupat & Environm Med, Dept Lab Med, Lund, Sweden.,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,LTH profilområde: Aerosoler,LTH profilområden,Lunds Tekniska Högskola,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Genetic Occupational and Environmental Medicine,Lund University Research Groups,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH
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Karolinska Institutet Karolinska Inst, Inst Environm Med, Nobels Vag 13, S-17177 Stockholm, Sweden (creator_code:org_t)
- 2021-09-27
- 2022
- Engelska.
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Ingår i: Scandinavian Journal of Work, Environment and Health. - : Scandinavian Journal of Work, Environment and Health. - 0355-3140 .- 1795-990X. ; 48:1, s. 21-30
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https://doi.org/10.5...
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Abstract
Ämnesord
Stäng
- Objective This study tested for an association between early cancer-related biomarkers and low-to-moderate exposure to fumes from welding mild steel.Methods Male, non-smoking participants from southern Sweden were recruited and examined (N=338, 171 welders and 167 controls); of these, 78 welders and 96 controls were examined on two occasions six years apart. Exposure to welding fumes was evaluated by measuring respirable dust, welding years, and cumulative exposure. DNA methylation of CpG sites within the cancer-related genes AHRR, F2RL3, and B3GNTL1 was measured by pyrosequencing and relative mitochondrial DNA copy number and telomere length were measured by qPCR in whole-blood samples. Multivariate models were used for longitudinal analysis.Results Median exposure to respirable dust was 0.7 mg/m3 at both timepoints, adjusted for use of personal protective equipment. Compared with controls, welders showed a significant decrease over time in DNA methylation of B3GNTL1 CpG1 and CpG4 [adjusted for age, body mass index, and smoking: β=-0.66, standard error (SE)=0.28; β=-0.48, SE=0.24, respectively]. In addition, exposure to respirable dust and cumulative exposure was associated with a decrease in methylation of F2RL3 CpG2 among all welders (adjusted β=-0.67, SE=0.23 and β=-0.03, SE=0.02, respectively). No significant associations were found for AHRR, mitochondrial DNA copy number, or telomere length.Conclusion Low-to-moderate exposure to welding fumes was associated with a small effect on selected early epigenetic biomarkers of cancer. The direction of the methylation pattern (lower methylation of specific CpG sites) indicates early lung cancer-related changes associated with mild steel welding.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- AHRR
- B3GNTL1
- DNA Methylation
- F2RL3
- lung cancer
- mitochondrial DNA
- occupational exposure
- respirable dust
- telomere length
- B3GNTL1
- DNA Methylation
- F2RL3
- Key terms AHRR
- lung cancer
- mitochondrial DNA
- occupational exposure
- respirable dust
- telomere length
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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