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Cellular Aging Secr...
Cellular Aging Secretes : a Comparison of Bone-Marrow-Derived and Induced Mesenchymal Stem Cells and Their Secretome Over Long-Term Culture
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- Marote, Ana (författare)
- University of Minho
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- Santos, Diogo (författare)
- University of Minho
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- Mendes-Pinheiro, Bárbara (författare)
- University of Minho
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- Serre-Miranda, Cláudia (författare)
- University of Minho
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- Anjo, Sandra I. (författare)
- University of Coimbra
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- Vieira, Joana (författare)
- Instituto Português de Oncologia do Porto Francisco Gentil (IPO)
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- Ferreira-Antunes, Filipa (författare)
- University of Minho
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- Correia, Joana Sofia (författare)
- University of Minho
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- Borges-Pereira, Caroline (författare)
- University of Minho
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- Pinho, Andreia G. (författare)
- University of Minho
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- Campos, Jonas (författare)
- University of Minho
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- Manadas, Bruno (författare)
- University of Coimbra
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- Teixeira, Manuel R. (författare)
- University of Porto,Instituto Português de Oncologia do Porto Francisco Gentil (IPO)
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- Correia-Neves, Margarida (författare)
- Karolinska Institutet
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- Pinto, Luísa (författare)
- University of Minho
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Costa, Pedro M. (författare)
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- Roybon, Laurent (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Wallenberg Neurocentrum, Lund,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Wallenberg Neuroscience Centre, Lund
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- Salgado, António J. (författare)
- University of Minho
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(creator_code:org_t)
- 2022-09-24
- 2023
- Engelska.
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Ingår i: Stem Cell Reviews and Reports. - : Springer Science and Business Media LLC. - 2629-3269 .- 2629-3277. ; 19:1, s. 248-263
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Mesenchymal stem cells (MSCs) hold promising therapeutic potential in several clinical applications, mainly due to their paracrine activity. The implementation of future secretome-based therapeutic strategies requires the use of easily accessible MSCs sources that provide high numbers of cells with homogenous characteristics. MSCs obtained from induced pluripotent stem cells (iMSCs) have been put forward as an advantageous alternative to the gold-standard tissue sources, such as bone marrow (BM-MSCs). In this study, we aimed at comparing the secretome of BM-MSCs and iMSCs over long-term culture. For that, we performed a broad characterization of both sources regarding their identity, proteomic secretome analysis, as well as replicative senescence and associated phenotypes, including its effects on MSCs secretome composition and immunomodulatory action. Our results evidence a rejuvenated phenotype of iMSCs, which is translated into a superior proliferative capacity before the induction of replicative senescence. Despite this significant difference between iMSCs and BM-MSCs proliferation, both untargeted and targeted proteomic analysis revealed a similar secretome composition for both sources in pre-senescent and senescent states. These results suggest that shifting from the use of BM-MSCs to a more advantageous source, like iMSCs, may yield similar therapeutic effects as identified over the past years for this gold-standard MSC source. Graphical Abstract: [Figure not available: see fulltext.].
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Bone marrow
- Human platelet lysate
- Induced pluripotent stem cells
- Mesenchymal stem cells
- Replicative senescence
- Secretome
- Senescence-associated secretory profile
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- ref (ämneskategori)
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Marote, Ana
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Santos, Diogo
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Mendes-Pinheiro, ...
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Serre-Miranda, C ...
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Anjo, Sandra I.
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Vieira, Joana
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visa fler...
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Ferreira-Antunes ...
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Correia, Joana S ...
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Borges-Pereira, ...
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Pinho, Andreia G ...
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Campos, Jonas
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Manadas, Bruno
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Teixeira, Manuel ...
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Correia-Neves, M ...
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Pinto, Luísa
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Costa, Pedro M.
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Roybon, Laurent
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Salgado, António ...
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Lunds universitet
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Karolinska Institutet