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How Do Modifiable R...
How Do Modifiable Risk Factors Affect Alzheimer's Disease Pathology or Mitigate Its Effect on Clinical Symptom Expression?
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- Ourry, Valentin (författare)
- McGill University
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- Binette, Alexa Pichet (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Douglas Mental Health University Institute,McGill University
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- St-Onge, Frédéric (författare)
- McGill University
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- Strikwerda-Brown, Cherie (författare)
- McGill University,University of Western Australia, Perth
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- Chagnot, Audrey (författare)
- University of Edinburgh
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- Poirier, Judes (författare)
- McGill University
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- Breitner, John (författare)
- McGill University
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- Arenaza-Urquijo, Eider M. (författare)
- Mayo Clinic Minnesota
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- Rabin, Jennifer S. (författare)
- University of Toronto
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- Buckley, Rachel (författare)
- Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School,Massachusetts General Hospital,Melbourne School of Psychological Sciences
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Gonneaud, Julie (författare)
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- Marchant, Natalie L. (författare)
- University College London
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- Villeneuve, Sylvia (författare)
- McConnell Brain Imaging Centre,McGill University
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(creator_code:org_t)
- 2024
- 2024
- Engelska 14 s.
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Ingår i: Biological Psychiatry. - 0006-3223. ; 95:11, s. 1006-1019
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Epidemiological studies show that modifiable risk factors account for approximately 40% of the population variability in risk of developing dementia, including sporadic Alzheimer's disease (AD). Recent findings suggest that these factors may also modify disease trajectories of people with autosomal-dominant AD. With positron emission tomography imaging, it is now possible to study the disease many years before its clinical onset. Such studies can provide key knowledge regarding pathways for either the prevention of pathology or the postponement of its clinical expression. The former “resistance pathway” suggests that modifiable risk factors could affect amyloid and tau burden decades before the appearance of cognitive impairment. Alternatively, the resilience pathway suggests that modifiable risk factors may mitigate the symptomatic expression of AD pathology on cognition. These pathways are not mutually exclusive and may appear at different disease stages. Here, in a narrative review, we present neuroimaging evidence that supports both pathways in sporadic AD and autosomal-dominant AD. We then propose mechanisms for their protective effect. Among possible mechanisms, we examine neural and vascular mechanisms for the resistance pathway. We also describe brain maintenance and functional compensation as bases for the resilience pathway. Improved mechanistic understanding of both pathways may suggest new interventions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Alzheimer disease
- Amyloid
- Modifiable risk factors
- Positron emission tomography
- Prevention
- Tau
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- Av författaren/redakt...
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Ourry, Valentin
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Binette, Alexa P ...
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St-Onge, Frédéri ...
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Strikwerda-Brown ...
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Chagnot, Audrey
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Poirier, Judes
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visa fler...
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Breitner, John
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Arenaza-Urquijo, ...
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Rabin, Jennifer ...
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Buckley, Rachel
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Gonneaud, Julie
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Marchant, Natali ...
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Villeneuve, Sylv ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Biological Psych ...
- Av lärosätet
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Lunds universitet