Dietary folate intake and pancreatic cancer risk: Results from the European prospective investigation into cancer and nutrition

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Dietary folate intake and pancreatic cancer risk : Results from the European prospective investigation into cancer and nutrition

Park, Jin Young (author): International Agency for Research on Cancer, World Health Organization

Bueno-de-Mesquita, H. Bas (author): Imperial College London,University Medical Center Utrecht,National Institute for Public Health and the Environment (RIVM)

Ferrari, Pietro (author): International Agency for Research on Cancer, World Health Organization

Weiderpass, Elisabete (author): Karolinska Institutet,Folkhälsan Research Center,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research

de Batlle, Jordi (author): CIBER Enfermedades Respiratorias (CIBERES)

Tjonneland, Anne (author): Danish Cancer Society

Kyro, Cecilie (author): Danish Cancer Society

Rebours, Vinciane (author): Paris Diderot University,Beaujon Hospital

Boutron-Ruault, Marie-Christine (author): University of Paris-Saclay,Stabilite genetique et oncogenese

Mancini, Francesca Romana (author): Stabilite genetique et oncogenese,University of Paris-Saclay

Katzke, Verena (author): German Cancer Research Centre

Kuehn, Tilman (author): German Cancer Research Centre

Boeing, Heiner (author): German Institute of Human Nutrition

Trichopoulou, Antonia (author): Hellenic Health Foundation, Athens

La Vecchia, Carlo (author): University of Milan,Hellenic Health Foundation, Athens

Kritikou, Maria (author): Hellenic Health Foundation, Athens

Masala, Giovanna (author)

Pala, Valeria (author): Istituto Nazionale dei Tumori

Tumino, Rosario (author)

Panico, Salvatore (author): University of Naples Federico II

Peeters, Petra H. (author): Imperial College London,University Medical Center Utrecht

Skeie, Guri (author): UiT The Arctic University of Norway, Tromsø

Merino, Susana (author)

Duell, Eric J. (author): Bellvitge University Hospital-IDIBELL

Rodriguez-Barranco, Miguel (author): University of Granada,CIBER Epidemiology and Public Health (CIBERESP)

Dorronsoro, Miren (author): CIBER Epidemiology and Public Health (CIBERESP)

Chirlaque, Maria-Dolores (author): University of Murcia,Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)

Ardanaz, Eva (author): Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)

Gylling, Björn, 1978- (author): Umeå University,Umeå universitet,Patologi

Schneede, Jörn (author): Umeå University,Umeå universitet,Farmakologi

Ericson, Ulrika (author): Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups

Sternby, Hanna (author): Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups

Khaw, Kay-Tee (author): University of Cambridge

Bradbury, Kathryn E. (author): University of Oxford

Huybrechts, Inge (author): International Agency for Research on Cancer, World Health Organization

Aune, Dagfinn (author): Imperial College London,Bjørknes University College

Vineis, Paolo (author): Imperial College London

Slimani, Nadia (author): International Agency for Research on Cancer, World Health Organization

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(creator_code:org_t)

2018-12-21
2019
English.
In: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 144:7, s. 1511-1521

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Journal article (peer-reviewed)

Abstract Subject headings

Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (>= 353 mu g/day) compared to the lowest (<241 mu g/day) was 0.81 (95% CI: 0.51, 1.31; p(trend) = 0.38). In current smokers, a positive trend was observed in PC risk across folate quartiles [HR = 4.42 (95% CI: 1.05, 18.62) for >= 353 mu g/day vs. <241 mu g/day, p(trend) = 0.01]. Nonetheless, there was no significant interaction between smoking and dietary folate intake (p(interaction) = 0.99). We found no association between dietary folate intake and PC risk in this large European study.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Keyword

dietary folate intake
pancreatic cancer
EPIC study
dietary folate intake
EPIC study
pancreatic cancer

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art (subject category)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Nutrition and Di ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

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By the university: Umeå University; Karolinska Institutet; Lund University

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