WFRF:(Bell Jordana T.)
Sökning: WFRF:(Bell Jordana T.) > (2011-2014) > The presence of met...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03196naa a2200457 4500 | |
| 001 | oai:DiVA.org:uu-275688 | |
| 003 | SwePub | |
| 008 | 160204s2013 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2756882 URI |
| 024 | 7 | a https://doi.org/10.1371/journal.pone.00559232 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Drong, Alexander W4 aut |
| 245 | 1 0 | a The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue. |
| 264 | c 2013-02-19 | |
| 264 | 1 | b Public Library of Science (PLoS),c 2013 |
| 338 | a print2 rdacarrier | |
| 520 | a Genetic variants that associate with DNA methylation at CpG sites (methylation quantitative trait loci, meQTLs) offer a potential biological mechanism of action for disease associated SNPs. We investigated whether meQTLs exist in abdominal subcutaneous adipose tissue (SAT) and if CpG methylation associates with metabolic syndrome (MetSyn) phenotypes. We profiled 27,718 genomic regions in abdominal SAT samples of 38 unrelated individuals using differential methylation hybridization (DMH) together with genotypes at 5,227,243 SNPs and expression of 17,209 mRNA transcripts. Validation and replication of significant meQTLs was pursued in an independent cohort of 181 female twins. We find that, at 5% false discovery rate, methylation levels of 149 DMH regions associate with at least one SNP in a ±500 kilobase cis-region in our primary study. We sought to validate 19 of these in the replication study and find that five of these significantly associate with the corresponding meQTL SNPs from the primary study. We find that none of the 149 meQTL top SNPs is a significant expression quantitative trait locus in our expression data, but we observed association between expression levels of two mRNA transcripts and cis-methylation status. Our results indicate that DNA CpG methylation in abdominal SAT is partly under genetic control. This study provides a starting point for future investigations of DNA methylation in adipose tissue. | |
| 650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
| 700 | 1 | a Nicholson, George4 aut |
| 700 | 1 | a Hedman, Åsa K4 aut |
| 700 | 1 | a Meduri, Eshwar4 aut |
| 700 | 1 | a Grundberg, Elin4 aut |
| 700 | 1 | a Small, Kerrin S4 aut |
| 700 | 1 | a Shin, So-Youn4 aut |
| 700 | 1 | a Bell, Jordana T4 aut |
| 700 | 1 | a Karpe, Fredrik4 aut |
| 700 | 1 | a Soranzo, Nicole4 aut |
| 700 | 1 | a Spector, Tim D4 aut |
| 700 | 1 | a McCarthy, Mark I4 aut |
| 700 | 1 | a Deloukas, Panos4 aut |
| 700 | 1 | a Rantalainen, Mattias4 aut |
| 700 | 1 | a Lindgren, Cecilia M4 aut |
| 773 | 0 | t PLOS ONEd : Public Library of Science (PLoS)g 8:2q 8:2x 1932-6203 |
| 856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0055923&type=printable |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-275688 |
| 856 | 4 8 | u https://doi.org/10.1371/journal.pone.0055923 |
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- Shin, So-Youn
- Bell, Jordana T
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