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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008913naa a2200721 4500
001oai:DiVA.org:uu-397295
003SwePub
008191125s2019 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3972952 URI
0247 a https://doi.org/10.1093/cvr/cvz0152 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Kessler, Thorstenu Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany4 aut
2451 0a Association of the coronary artery disease risk gene GUCY1A3 with ischaemic events after coronary intervention
264 c 2019-02-14
264 1b OXFORD UNIV PRESS,c 2019
338 a print2 rdacarrier
520 a Aim A common genetic variant at the GUCY1A3 coronary artery disease locus has been shown to influence platelet aggregation. The risk of ischaemic events including stent thrombosis varies with the efficacy of aspirin to inhibit platelet reactivity. This study sought to investigate whether homozygous GUCY1A3 (rs7692387) risk allele carriers display higher on-aspirin platelet reactivity and risk of ischaemic events early after coronary intervention. Methods and results The association of GUCY1A3 genotype and on-aspirin platelet reactivity was analysed in the genetics substudy of the ISAR-ASPI registry (n = 1678) using impedance aggregometry. The clinical outcome cardiovascular death or stent thrombosis within 30 days after stenting was investigated in a meta-analysis of substudies of the ISAR-ASPI registry, the PLATO trial (n = 3236), and the Utrecht Coronary Biobank (n = 1003) comprising a total 5917 patients. Homozygous GUCY1A3 risk allele carriers (GG) displayed increased on-aspirin platelet reactivity compared with non-risk allele (AA/AG) carriers [150 (interquartile range 91-209) vs. 134 (85-194) AU.min, P < 0.01]. More homozygous risk allele carriers, compared with non-risk allele carriers, were assigned to the high-risk group for ischaemic events (>203AU.min; 29.5 vs. 24.2%, P = 0.02). Homozygous risk allele carriers were also at higher risk for cardiovascular death or stent thrombosis (hazard ratio 1.70, 95% confidence interval 1.08-2.68; P = 0.02). Bleeding risk was not altered. Conclusion We conclude that homozygous GUCY1A3 risk allele carriers are at increased risk of cardiovascular death or stent thrombosis within 30 days after coronary stenting, likely due to higher on-aspirin platelet reactivity. Whether GUCY1A3 genotype helps to tailor antiplatelet treatment remains to be investigated.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a On-aspirin platelet reactivity
653 a Genetic variation
653 a Stent thrombosis
653 a Genome-wide association studies
653 a Platelet aggregation
7001 a Wolf, Bernhardu Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany4 aut
7001 a Eriksson, Niclas,d 1978-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)nieri103
7001 a Kofink, Danielu Univ Utrecht, Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands4 aut
7001 a Mahmoodi, Bakhtawar K.u St Antonius Hosp, Cardiol Dept, Nieuwegein, Netherlands4 aut
7001 a Rai, Himanshuu Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany4 aut
7001 a Tragante, Viniciusu Univ Utrecht, Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands4 aut
7001 a Åkerblom, Axel,d 1977-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)axeak985
7001 a Becker, Richard C.u Univ Cincinnati, Heart Lung & Vasc Inst, Div Cardiovasc Hlth & Dis, Cincinnati, OH USA4 aut
7001 a Bernlochner, Isabellu Tech Univ Munich, Klinikum Rechts Isar, Med Klin & Poliklin 1, Munich, Germany4 aut
7001 a Bopp, Romanu Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany4 aut
7001 a James, Stefan,d 1964-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)stjam367
7001 a Katus, Hugo A.u Heidelberg Univ, Innere Med Kardiol Angiol & Pneumol 3, Heidelberg, Germany;DZHK eV, Partner Site Heidelberg, Heidelberg, Germany4 aut
7001 a Mayer, Katharinau Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany4 aut
7001 a Munz, Matthiasu Univ Lubeck, Inst Cardiogenet, Lubeck, Germany;Univ Heart Ctr Lubeck, Lubeck, Germany;DZHK eV, Partner Site Hamburg Kiel Lubeck, Lubeck, Germany;Charite Univ Med Berlin, Berlin, Germany;Free Univ Berlin, Berlin, Germany;Humboldt Univ, Berlin, Germany;Berlin Inst Hlth, Inst Dent & Craniofacial Sci, Dept Periodontol & Synopt Dent, Berlin, Germany4 aut
7001 a Nordio, Francescou Brigham & Womens Hosp, TIMI Study Grp, 75 Francis St, Boston, MA 02115 USA4 aut
7001 a O'Donoghue, Michelle L.u Brigham & Womens Hosp, TIMI Study Grp, 75 Francis St, Boston, MA 02115 USA4 aut
7001 a Sager, Hendrik B.u Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany4 aut
7001 a Sibbing, Dirku Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany;Ludwig Maximilians Univ Munchen, Klinikum Univ Munchen, Med Klin & Poliklin 1, Munich, Germany4 aut
7001 a Solakov, Lindau Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany4 aut
7001 a Storey, Robert F.u Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, S Yorkshire, England4 aut
7001 a Wobst, Janau Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany4 aut
7001 a Asselbergs, Folkert W.u Univ Utrecht, Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands;Fac Populat Hlth Sci, Inst Cardiovasc Sci, London, England;UCL, Hlth Data Res UK, London, England;UCL, Inst Hlth Informat, London, England4 aut
7001 a Byrne, Robert A.u Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany4 aut
7001 a Erdmann, Jeanetteu Univ Lubeck, Inst Cardiogenet, Lubeck, Germany;Univ Heart Ctr Lubeck, Lubeck, Germany;DZHK eV, Partner Site Hamburg Kiel Lubeck, Lubeck, Germany4 aut
7001 a Koenig, Wolfgangu Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany4 aut
7001 a Laugwitz, Karl-Ludwigu Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany;Tech Univ Munich, Klinikum Rechts Isar, Med Klin & Poliklin 1, Munich, Germany4 aut
7001 a ten Berg, Jurrien M.u St Antonius Hosp, Cardiol Dept, Nieuwegein, Netherlands4 aut
7001 a Wallentin, Lars,d 1943-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)larswall
7001 a Kastrati, Adnanu Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany4 aut
7001 a Schunkert, Heribertu Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany4 aut
7102 a Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany;Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germanyb Uppsala kliniska forskningscentrum (UCR)4 org
7730 t Cardiovascular Researchd : OXFORD UNIV PRESSg 115:10, s. 1512-1518q 115:10<1512-1518x 0008-6363x 1755-3245
8564 u https://academic.oup.com/cardiovascres/article-pdf/115/10/1512/28981341/cvz015.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-397295
8564 8u https://doi.org/10.1093/cvr/cvz015

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