SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Bruhn Sören)
 

Search: WFRF:(Bruhn Sören) > MicroRNAs act compl...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005235naa a2200637 4500
001oai:gup.ub.gu.se/186269
003SwePub
008240528s2013 | |||||||||||000 ||eng|
009oai:DiVA.org:liu-99867
0247 a https://gup.ub.gu.se/publication/1862692 URI
0247 a https://doi.org/10.1261/rna.038414.1132 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-998672 URI
040 a (SwePub)gud (SwePub)liu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Chavali, Sreenivasu MRC Laboratory of Molecular Biology, Cambridge, United Kingdom4 aut0 (Swepub:gu)xchasr
2451 0a MicroRNAs act complementarily to regulate disease-related mRNA modules in human diseases
264 c 2013-09-23
264 1b Cold Spring Harbor Laboratory,c 2013
338 a electronic2 rdacarrier
520 a MicroRNAs (miRNAs) play a key role in regulating mRNA expression, and individual miRNAs have been proposed as diagnostic and therapeutic candidates. The identification of such candidates is complicated by the involvement of multiple miRNAs and mRNAs as well as unknown disease topology of the miRNAs. Here, we investigated if disease-associated miRNAs regulate modules of disease-associated mRNAs, if those miRNAs act complementarily or synergistically, and if single or combinations of miRNAs can be targeted to alter module functions. We first analyzed publicly available miRNA and mRNA expression data for five different diseases. Integrated target prediction and network-based analysis showed that the miRNAs regulated modules of disease-relevant genes. Most of the miRNAs acted complementarily to regulate multiple mRNAs. To functionally test these findings, we repeated the analysis using our own miRNA and mRNA expression data from CD4+ T cells from patients with seasonal allergic rhinitis. This is a good model of complex diseases because of its well-defined phenotype and pathogenesis. Combined computational and functional studies confirmed that miRNAs mainly acted complementarily and that a combination of two complementary miRNAs, miR-223 and miR-139-3p, could be targeted to alter disease-relevant module functions, namely, the release of type 2 helper T-cell (Th2) cytokines. Taken together, our findings indicate that miRNAs act complementarily to regulate modules of disease-related mRNAs and can be targeted to alter disease-relevant functions.
650 7a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
653 a microRNA
653 a diseases
653 a regulation
653 a modules
653 a NETWORK-BASED ANALYSIS
653 a PROTEIN COMPLEXES
653 a EXPRESSION
653 a TARGETS
653 a PREDICTION
653 a DISORDERS
653 a RESPONSES
653 a CANCER
653 a GENES
653 a CELLS
7001 a Bruhn, Sörenu Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet4 aut0 (Swepub:liu)sorbr27
7001 a Tiemann, Katrinu Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet4 aut0 (Swepub:liu)katti04
7001 a Saetrom, P.u Norwegian University of Science and Technology, Trondheim, Norway4 aut
7001 a Barrenäs, Fredrik,d 1981u Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet4 aut0 (Swepub:liu)freba19
7001 a Saito, T.u Norwegian University of Science and Technology, Trondheim, Norway4 aut
7001 a Kanduri, Kartiek,d 1986u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,University of Gothenburg, Sweden4 aut0 (Swepub:gu)xkanka
7001 a Wang, Huiu Linköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Avdelningen för kliniska vetenskaper,Hälsouniversitetet4 aut0 (Swepub:liu)huiwa84
7001 a Benson, Mikael,d 1954u Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet4 aut0 (Swepub:liu)mikbe05
7102 a MRC Laboratory of Molecular Biology, Cambridge, United Kingdomb Avdelningen för kliniska vetenskaper4 org
7730 t Rna-a Publication of the Rna Societyd : Cold Spring Harbor Laboratoryg 19:11, s. 1552-1562q 19:11<1552-1562x 1355-8382x 1469-9001
7730 t RNAd : Cold Spring Harbor Laboratoryg 19:11, s. 1552-1562q 19:11<1552-1562x 1469-9001
8564 u https://gup.ub.gu.se/publication/186269x primaryx freey FULLTEXT
8564 u http://rnajournal.cshlp.org/content/19/11/1552.full.pdf
8564 u https://liu.diva-portal.org/smash/get/diva2:658538/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://gup.ub.gu.se/publication/186269
8564 8u https://doi.org/10.1261/rna.038414.113
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-99867

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view