Sökning: WFRF:(Burman Joachim 1974 )
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Sustained remission...
Sustained remission in multiple sclerosis after hematopoietic stem cell transplantation
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- Tolf, Andreas (författare)
- Uppsala universitet,Landtblom: Neurovetenskap
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- Fagius, Jan (författare)
- Uppsala universitet,Landtblom: Neurovetenskap
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- Carlson, Kristina (författare)
- Uppsala universitet,Hematologi
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- Åkerfeldt, Torbjörn (författare)
- Uppsala universitet,Klinisk kemi
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- Granberg, Tobias (författare)
- Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden; Karolinska Univ Hosp, Dept Radiol, Div Neuroradiol, Stockholm, Sweden
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- Larsson, Elna-Marie (författare)
- Uppsala universitet,Radiologi
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- Burman, Joachim, 1974- (författare)
- Uppsala universitet,Landtblom: Neurovetenskap
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(creator_code:org_t)
- 2019-08-05
- 2019
- Engelska.
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Ingår i: Acta Neurologica Scandinavica. - : Hindawi Limited. - 0001-6314 .- 1600-0404. ; 140:5, s. 320-327
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objectives: To determine whether treatment with autologous hematopoietic stem cell transplantation (HSCT) can induce sustained complete remission in patients with multiple sclerosis (MS).Material and methods: Case series of patients with relapsing‐remitting MS (n = 10) treated at a single center between 2004 and 2007 and followed up for 10 years. The patients were treated with a BEAM/ATG conditioning regimen (n = 9) or a cyclophosphamide/ATG conditioning regimen (n = 1) followed by infusion of unmanipulated autologous hematopoietic stem cells. The primary endpoint was sustained complete remission. Sustained complete remission was defined as “no evidence of disease activity‐4,” sustained for a period of at least 5 years without any ongoing disease‐modifying treatment. Furthermore, MS was considered as “resolved” if intrathecal IgG production and cerebrospinal fluid neurofilament light levels were normalized as well.Results: Five out of 10 patients were in sustained complete remission at the end of the study. In three of them, MS was resolved.Conclusions: Our data demonstrate that sustained complete remission after autologous HSCT for MS is possible.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- cerebrospinal fluid
- hematopoietic stem cell transplantation
- magnetic resonance imaging
- multiple sclerosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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