WFRF:(Burman Joachim Docent 1974 )
Sökning: WFRF:(Burman Joachim Docent 1974 ) > Biochemical Differe...
- Herman, StephanieUppsala universitet,Klinisk kemi,Institutionen för farmaceutisk biovetenskap,Science for Life Laboratory, SciLifeLab,Spjuth group (författare)
Biochemical Differences in Cerebrospinal Fluid between Secondary Progressive and Relapsing-Remitting Multiple Sclerosis
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
- 2019-01-24
- MDPI AG,2019
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-375564
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-375564URI
- https://doi.org/10.3390/cells8020084DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- To better understand the pathophysiological differences between secondary progressive multiple sclerosis (SPMS) and relapsing-remitting multiple sclerosis (RRMS), and to identify potential biomarkers of disease progression, we applied high-resolution mass spectrometry (HRMS) to investigate the metabolome of cerebrospinal fluid (CSF). The biochemical differences were determined using partial least squares discriminant analysis (PLS-DA) and connected to biochemical pathways as well as associated to clinical and radiological measures. Tryptophan metabolism was significantly altered, with perturbed levels of kynurenate, 5-hydroxytryptophan, 5-hydroxyindoleacetate, and N-acetylserotonin in SPMS patients compared with RRMS and controls. SPMS patients had altered kynurenine compared with RRMS patients, and altered indole-3-acetate compared with controls. Regarding the pyrimidine metabolism, SPMS patients had altered levels of uridine and deoxyuridine compared with RRMS and controls, and altered thymine and glutamine compared with RRMS patients. Metabolites from the pyrimidine metabolism were significantly associated with disability, disease activity and brain atrophy, making them of particular interest for understanding the disease mechanisms and as markers of disease progression. Overall, these findings are of importance for the characterization of the molecular pathogenesis of SPMS and support the hypothesis that the CSF metabolome may be used to explore changes that occur in the transition between the RRMS and SPMS pathologies.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
- cerebrospinal fluid
- mass spectrometry
- metabolomics
- multiple sclerosis
- pyrimidine
- tryptophan
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Åkerfeldt, TorbjörnUppsala universitet,Klinisk kemi(Swepub:uu)tak20812 (författare)
- Spjuth, Ola,Docent,1977-Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Science for Life Laboratory, SciLifeLab(Swepub:uu)olspj499 (författare)
- Burman, Joachim,1974-Uppsala universitet,Neurologi(Swepub:uu)joabu293 (författare)
- Kultima, KimUppsala universitet,Klinisk kemi(Swepub:uu)kikul535 (författare)
- Uppsala universitetKlinisk kemi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Cells: MDPI AG8:22073-4409
Internetlänk
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