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Sökning: WFRF:(Carbonnel M.) > (2015-2019) > Association between...

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FältnamnIndikatorerMetadata
00006649naa a2201033 4500
001oai:DiVA.org:umu-158366
003SwePub
008190429s2019 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:140666794
009oai:lup.lub.lu.se:3cdc1f4c-aa54-4b58-8652-d5a9ddc5132b
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1583662 URI
0247 a https://doi.org/10.1016/j.jhep.2018.12.0142 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1406667942 URI
0247 a https://lup.lub.lu.se/record/3cdc1f4c-aa54-4b58-8652-d5a9ddc5132b2 URI
040 a (SwePub)umud (SwePub)kid (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Baumeister, Sebastian E.u Ludwig-Maximilian University of Munich,University Medicine Greifswald4 aut
2451 0a Association between physical activity and risk of hepatobiliary cancers :b A multinational cohort study
264 1b Elsevier BV,c 2019
338 a print2 rdacarrier
520 a Background & Aims: To date, evidence on the association between physical activity and risk of hepatobiliary cancers has been inconclusive. We examined this association in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC).Methods: We identified 275 hepatocellular carcinoma (HCC) cases, 93 intrahepatic bile duct cancers (IHBCs), and 164 non-gallbladder extrahepatic bile duct cancers (NGBCs) among 467,336 EPIC participants (median follow-up 14.9 years). We estimated cause-specific hazard ratios (HRs) for total physical activity and vigorous physical activity and performed mediation analysis and secondary analyses to assess robustness to confounding (e.g. due to hepatitis virus infection).Results: In the EPIC cohort, the multivariable-adjusted HR of HCC was 0.55 (95% CI 0.38–0.80) comparing active and inactive individuals. Regarding vigorous physical activity, for those reporting >2 hours/week compared to those with no vigorous activity, the HR for HCC was 0.50 (95% CI 0.33–0.76). Estimates were similar in sensitivity analyses for confounding. Total and vigorous physical activity were unrelated to IHBC and NGBC. In mediation analysis, waist circumference explained about 40% and body mass index 30% of the overall association of total physical activity and HCC.Conclusions: These findings suggest an inverse association between physical activity and risk of HCC, which is potentially mediated by obesity.Lay summary: In a pan-European study of 467,336 men and women, we found that physical activity is associated with a reduced risk of developing liver cancers over the next decade. This risk was independent of other liver cancer risk factors, and did not vary by age, gender, smoking status, body weight, and alcohol consumption.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Hepatobiliary cancer
653 a Hepatocellular carcinoma
653 a Liver cancer
653 a Physical activity
653 a Hepatobiliary cancer
653 a Hepatocellular carcinoma
653 a Liver cancer
653 a Physical activity
7001 a Schlesinger, Sabrina4 aut
7001 a Aleksandrova, Krasimira4 aut
7001 a Jochem, Carmen4 aut
7001 a Jenab, Mazda4 aut
7001 a Gunter, Marc J.4 aut
7001 a Overvad, Kim4 aut
7001 a Tjonneland, Anne4 aut
7001 a Boutron-Ruault, Marie-Christine4 aut
7001 a Carbonnel, Franck4 aut
7001 a Fournier, Agnes4 aut
7001 a Kuehn, Tilman4 aut
7001 a Kaaks, Rudolf4 aut
7001 a Pischon, Tobias4 aut
7001 a Boeing, Heiner4 aut
7001 a Trichopoulou, Antonia4 aut
7001 a Bamia, Christina4 aut
7001 a La Vecchia, Carlo4 aut
7001 a Masala, Giovanna4 aut
7001 a Panico, Salvatore4 aut
7001 a Fasanelli, Francescau University of Regensburg4 aut
7001 a Tumino, Rosario4 aut
7001 a Grioni, Sara4 aut
7001 a de Mesquita, Bas Bueno4 aut
7001 a Vermeulen, Roel4 aut
7001 a May, Anne M.4 aut
7001 a Borch, Kristin B.4 aut
7001 a Oyeyemi, Sunday O.4 aut
7001 a Ardanaz, Eva4 aut
7001 a Rodriguez-Barranco, Miguel4 aut
7001 a Chirlaque Lopez, Maria Dolores4 aut
7001 a Felez-Nobrega, Mireia4 aut
7001 a Sonestedt, Emilyu Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-eso
7001 a Ohlsson, Bodilu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)kir-boh
7001 a Hemmingsson, Oskar,d 1975-u Umeå universitet,Kirurgi4 aut0 (Swepub:umu)osrhen96
7001 a Werner, Mårtenu Umeå universitet,Avdelningen för medicin4 aut0 (Swepub:umu)manwer04
7001 a Perez-Cornago, Aurora4 aut
7001 a Ferrari, Pietro4 aut
7001 a Stepien, Magdalena4 aut
7001 a Freisling, Heinz4 aut
7001 a Tsilidis, Konstantinos K.4 aut
7001 a Ward, Heather4 aut
7001 a Riboli, Elio4 aut
7001 a Weiderpass, Elisabeteu Karolinska Institutet4 aut
7001 a Leitzmann, Michael F.4 aut
7102 a Ludwig-Maximilian University of Munichb University Medicine Greifswald4 org
7102 a et al.
7730 t Journal of Hepatologyd : Elsevier BVg 70:5, s. 885-892q 70:5<885-892x 0168-8278x 1600-0641
8564 u http://dspace.library.uu.nl/bitstream/1874/385064/1/Association_betrween_physical_activity.pdf
8564 u http://dx.doi.org/10.1016/j.jhep.2018.12.014y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158366
8564 8u https://doi.org/10.1016/j.jhep.2018.12.014
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:140666794
8564 8u https://lup.lub.lu.se/record/3cdc1f4c-aa54-4b58-8652-d5a9ddc5132b

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