WFRF:(Carlsson Hans Erik)
Sökning: WFRF:(Carlsson Hans Erik) > High plasma cortico...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02925naa a2200349 4500 | |
| 001 | oai:DiVA.org:uu-78874 | |
| 003 | SwePub | |
| 008 | 060331s2005 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-788742 URI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Abelson, Klasu Uppsala universitet,Försöksdjursvetenskap4 aut0 (Swepub:uu)klabe226 |
| 245 | 1 0 | a High plasma corticosterone levels persist during frequent automatic blood sampling in rats |
| 264 | 1 | c 2005 |
| 338 | a print2 rdacarrier | |
| 520 | a Corticosterone levels in blood may be used as a marker of stress in rodents, provided that the blood sampling procedure itself is non-stressful. Automated blood sampling equipment (Accusampler®) allows blood sampling without any interference with the animal and might be useful as a tool for an on-line measurement of stress markers in blood. However, the impact of the blood sampling itself on the corticosterone levels in blood is unknown. The present study was designed to evaluate whether the frequency of blood sampling influences the plasma corticosterone levels in male and female rats. During anaesthesia, a catheter was placed in the jugular vein and attached to an Accusampler®. Blood samples (200 μl) were withdrawn with a high (24 samples) or low frequency (3 samples) during a six-hour period immediately after the catheter insertion. The corticosterone levels in the plasma were quantified with ELISA. The corticosterone levels persisted at high post-operation concentrations when blood was collected frequently, while the levels steadily declined significantly during low-frequency sampling. The corticosterone levels were higher in female than in male rats, but the curves were similar. The present study elucidates the importance of considering the frequency of blood withdrawal during automated blood sampling. This parameter may have an impact on the experimental results when using blood corticosterone levels as a stress marker, but also during any in vivo study where blood is collected, since high corticosterone levels may affect the normal physiology of the animals. | |
| 653 | a rat | |
| 653 | a stress | |
| 653 | a corticosterone | |
| 653 | a Accusampler® | |
| 653 | a blood sampling | |
| 653 | a automatic blood sampling | |
| 700 | 1 | a Adem, Bashiru Uppsala universitet,Försöksdjursvetenskap4 aut |
| 700 | 1 | a Royo, Felixu Uppsala universitet,Försöksdjursvetenskap4 aut |
| 700 | 1 | a Carlsson, Hans-Eriku Uppsala universitet,Försöksdjursvetenskap4 aut0 (Swepub:uu)hca27522 |
| 700 | 1 | a Hau, Jann4 aut |
| 710 | 2 | a Uppsala universitetb Försöksdjursvetenskap4 org |
| 773 | 0 | t In Vivog 19:5, s. 815-19q 19:5<815-19x 0258-851Xx 1791-7549 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-78874 |
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- Abelson, Klas
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- Hau, Jann
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- Uppsala universitet
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