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Splanchnic vein thr...
Splanchnic vein thrombosis in myeloproliferative neoplasms : Risk factors for recurrences in a cohort of 181 patients
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- De Stefano, V. (author)
- Catholic University of the Sacred Heart, Rome
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- Vannucchi, A. M. (author)
- University of Florence
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- Ruggeri, M. (author)
- Ospedale San Bortolo
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- Cervantes, F. (author)
- Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS)
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- Alvarez-Larrán, A. (author)
- Hospital del Mar Medical Research Institute
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- Iurlo, A. (author)
- Maggiore Hospital Policlinico
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- Randi, M. L. (author)
- University of Padova
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- Pieri, L. (author)
- University of Florence
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- Rossi, E. (author)
- Catholic University of the Sacred Heart, Rome
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- Guglielmelli, P. (author)
- University of Florence
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- Betti, S. (author)
- Catholic University of the Sacred Heart, Rome
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- Elli, E. (author)
- University of Milano-Bicocca
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- Finazzi, M. C. (author)
- Papa Giovanni XXIII Hospital
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- Finazzi, G. (author)
- Papa Giovanni XXIII Hospital
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- Zetterberg, E. (author)
- Lund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups,Skåne University Hospital
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- Vianelli, N. (author)
- St. Orsola-Malpighi University Hospital
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- Gaidano, G. (author)
- University of Eastern Piedmont
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- Nichele, I. (author)
- Ospedale San Bortolo
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- Cattaneo, D. (author)
- Maggiore Hospital Policlinico
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- Palova, M. (author)
- University Hospital of Olomouc
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- Ellis, M. H. (author)
- Meir Medical Center
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- Cacciola, E. (author)
- University of Catania
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- Tieghi, A. (author)
- Arcispedale Santa Maria Nuova
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- Hernandez-Boluda, J. C. (author)
- University and Polytechnic Hospital la Fe
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- Pungolino, E. (author)
- Niguarda Hospital
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- Specchia, G. (author)
- Bari University Hospital
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- Rapezzi, D. (author)
- A.O. Santa Croce e Carle
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- Forcina, A. (author)
- San Raffaele Scientific Institute
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- Musolino, C. (author)
- Bari University Hospital
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- Carobbio, A. (author)
- Papa Giovanni XXIII Hospital
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- Griesshammer, M. (author)
- Ruhr-University Bochum
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- Barbui, T. (author)
- Papa Giovanni XXIII Hospital
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(creator_code:org_t)
- 2016-11-04
- 2016
- English.
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In: Blood Cancer Journal. - : Springer Science and Business Media LLC. - 2044-5385. ; 6:11
- Related links:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We retrospectively studied 181 patients with polycythaemia vera (n=67), essential thrombocythaemia (n=67) or primary myelofibrosis (n=47), who presented a first episode of splanchnic vein thrombosis (SVT). Budd-Chiari syndrome (BCS) and portal vein thrombosis were diagnosed in 31 (17.1%) and 109 (60.3%) patients, respectively; isolated thrombosis of the mesenteric or splenic veins was detected in 18 and 23 cases, respectively. After this index event, the patients were followed for 735 patient years (pt-years) and experienced 31 recurrences corresponding to an incidence rate of 4.2 per 100 pt-years. Factors associated with a significantly higher risk of recurrence were BCS (hazard ratio (HR): 3.03), history of previous thrombosis (HR: 3.62), splenomegaly (HR: 2.66) and leukocytosis (HR: 2.8). Vitamin K-antagonists (VKA) were prescribed in 85% of patients and the recurrence rate was 3.9 per 100 pt-years, whereas in the small fraction (15%) not receiving VKA more recurrences (7.2 per 100 pt-years) were reported. Intracranial and extracranial major bleeding was recorded mainly in patients on VKA and the corresponding rate was 2.0 per 100 pt-years. In conclusion, despite anticoagulation treatment, the recurrence rate after SVT in myeloproliferative neoplasms is high and suggests the exploration of new avenues of secondary prophylaxis with new antithrombotic drugs and JAK-2 inhibitors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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De Stefano, V.
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Vannucchi, A. M.
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Ruggeri, M.
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Cervantes, F.
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Alvarez-Larrán, ...
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Iurlo, A.
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show more...
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Randi, M. L.
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Pieri, L.
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Rossi, E.
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Guglielmelli, P.
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Betti, S.
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Elli, E.
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Finazzi, M. C.
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Finazzi, G.
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Zetterberg, E.
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Vianelli, N.
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Gaidano, G.
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Nichele, I.
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Cattaneo, D.
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Palova, M.
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Ellis, M. H.
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Cacciola, E.
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Tieghi, A.
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Hernandez-Boluda ...
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Pungolino, E.
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Specchia, G.
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Rapezzi, D.
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Forcina, A.
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Musolino, C.
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Carobbio, A.
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Griesshammer, M.
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Barbui, T.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Blood Cancer Jou ...
- By the university
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Lund University