Sökning: WFRF:(Chapurlat R. D.) > A meta-analysis of ...
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024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5335142 URI |
024 | 7 | a https://doi.org/10.1007/s00198-023-07012-12 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-502992 URI |
024 | 7 | a https://gup.ub.gu.se/publication/3343622 URI |
024 | 7 | a https://lup.lub.lu.se/record/8339f7a6-a301-4806-ada7-2fcf28536d072 URI |
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041 | a engb eng | |
042 | 9 SwePub | |
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100 | 1 | a Vandenput, Liesbethu Australian Catholic Univ, Mary McKillop Inst Hlth Res, Melbourne, Vic, Australia.,Australian Catholic University4 aut |
245 | 1 0 | a A meta-analysis of previous falls and subsequent fracture risk in cohort studies |
264 | 1 | b Springer,c 2024 |
338 | a print2 rdacarrier | |
520 | a SummaryThe relationship between self-reported falls and fracture risk was estimated in an international meta-analysis of individual-level data from 46 prospective cohorts. Previous falls were associated with an increased fracture risk in women and men and should be considered as an additional risk factor in the FRAX® algorithm.IntroductionPrevious falls are a well-documented risk factor for subsequent fracture but have not yet been incorporated into the FRAX algorithm. The aim of this study was to evaluate, in an international meta-analysis, the association between previous falls and subsequent fracture risk and its relation to sex, age, duration of follow-up, and bone mineral density (BMD).MethodsThe resource comprised 906,359 women and men (66.9% female) from 46 prospective cohorts. Previous falls were uniformly defined as any fall occurring during the previous year in 43 cohorts; the remaining three cohorts had a different question construct. The association between previous falls and fracture risk (any clinical fracture, osteoporotic fracture, major osteoporotic fracture, and hip fracture) was examined using an extension of the Poisson regression model in each cohort and each sex, followed by random-effects meta-analyses of the weighted beta coefficients.ResultsFalls in the past year were reported in 21.4% of individuals. During a follow-up of 9,102,207 person-years, 87,352 fractures occurred of which 19,509 were hip fractures. A previous fall was associated with a significantly increased risk of any clinical fracture both in women (hazard ratio (HR) 1.42, 95% confidence interval (CI) 1.33–1.51) and men (HR 1.53, 95% CI 1.41–1.67). The HRs were of similar magnitude for osteoporotic, major osteoporotic fracture, and hip fracture. Sex significantly modified the association between previous fall and fracture risk, with predictive values being higher in men than in women (e.g., for major osteoporotic fracture, HR 1.53 (95% CI 1.27–1.84) in men vs. HR 1.32 (95% CI 1.20–1.45) in women, P for interaction = 0.013). The HRs associated with previous falls decreased with age in women and with duration of follow-up in men and women for most fracture outcomes. There was no evidence of an interaction between falls and BMD for fracture risk. Subsequent risk for a major osteoporotic fracture increased with each additional previous fall in women and men.ConclusionsA previous self-reported fall confers an increased risk of fracture that is largely independent of BMD. Previous falls should be considered as an additional risk factor in future iterations of FRAX to improve fracture risk prediction. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
653 | a fracture risk | |
653 | a hip fracture | |
653 | a major osteoporotic fracture | |
653 | a meta-analysis | |
653 | a previous falls | |
653 | a risk factors | |
653 | a fracture risk | |
653 | a hip fracture | |
653 | a major osteoporotic fracture | |
653 | a meta-analysis | |
653 | a previous falls | |
653 | a risk factors | |
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700 | 1 | a Liu, Enwuu Australian Catholic Univ, Mary McKillop Inst Hlth Res, Melbourne, Vic, Australia.4 aut |
700 | 1 | a Schini, Marianu Univ Sheffield, Sch Med & Populat Hlth, Div Clin Med, Sheffield, S Yorkshire, England.4 aut |
700 | 1 | a Åkesson, K.E.u Lund University,Lunds universitet,Medicinska fakulteten,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Faculty of Medicine,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Lund Univ, Dept Clin Sci, Clin & Mol Osteoporosis Res Unit, Lund, Sweden.;Skane Univ Hosp, Dept Orthoped, Malmö, Sweden.4 aut0 (Swepub:lu)orto-kak |
700 | 1 | a McGuigan, F.E.A.u Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Univ Massachusetts, GLOW Coordinating Ctr, Ctr Outcomes Res, Med Sch, Worcester, MA USA.,Lund Univ, Dept Clin Sci, Clin & Mol Osteoporosis Res Unit, Lund, Sweden.4 aut0 (Swepub:lu)med-fam |
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700 | 1 | a Bischoff-Ferrari, Heike A.u Univ Hosp, Dept Aging Med & Aging Res, Zurich, Switzerland.;Univ Zurich, Zurich, Switzerland.;Univ Zurich, Ctr Aging & Mobil, Zurich, Switzerland.;City Hosp, Zurich, Switzerland.4 aut |
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700 | 1 | a Cauley, Jane A.u Univ Pittsburgh, Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA.4 aut |
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700 | 1 | a Chapurlat, Rolandu Univ Claude Bernard Lyon1, Hop Edouard Herriot, INSERM, UMR 1033, Lyon, France.4 aut |
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700 | 1 | a Cooper, Cyrusu Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, Hants, England.;Univ Southampton, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England.;Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England.;Univ Oxford, NIHR Oxford Biomed Res Unit, Oxford, England.4 aut |
700 | 1 | a Crandall, Carolyn J.u Univ Calif Los Angeles, David Geffen Sch Med, Div Gen Internal Med & Hlth Serv Res, Los Angeles, CA 90095 USA.4 aut |
700 | 1 | a Cummings, Steven R.u Calif Pacific Med Ctr, San Francisco Coordinating Ctr, Res Inst, San Francisco, CA USA.4 aut |
700 | 1 | a da Silva, José A. P.u Univ Coimbra, Coimbra Inst Clin & Biomed Res, Fac Med, Coimbra, Portugal.;Ctr Hosp E Univ Coimbra, Rheumatol Dept, Coimbra, Portugal.4 aut |
700 | 1 | a Dawson-Hughes, Bessu Tufts Univ, Bone Metab Lab, Jean Mayer US Dept Agr, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.4 aut |
700 | 1 | a Diez-Perez, Adolfou Hosp del Mar, Dept Internal Med, Barcelona, Spain.;Autonomous Univ Barcelona, CIBERFES, Barcelona, Spain.4 aut |
700 | 1 | a Dufour, Alyssa B.u Hebrew SeniorLife, Marcus Inst Aging Res, Boston, MA USA.;Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA.;Harvard Med Sch, Boston, MA 02115 USA.4 aut |
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700 | 1 | a Fujita, Yukiu Kindai Univ, Ctr Med Educ & Clin Training, Fac Med, Osaka, Japan.4 aut |
700 | 1 | a Fujiwara, Saekou Yasuda Womens Univ, Dept Pharm, Hiroshima, Japan.4 aut |
700 | 1 | a Glüer, Claus-Christianu Univ Kiel, Univ Med Ctr Schleswig Holstein Kiel, Mol Imaging North Competence Ctr, Dept Radiol & Neuroradiol,Sect Biomed Imaging, Kiel, Germany.4 aut |
700 | 1 | a Goldshtein, Inbalu Maccabi Healthcare Serv, Maccabitech Inst Res & Innovat, Tel Aviv, Israel.;Tel Aviv Univ, Sch Publ Hlth, Dept Epidemiol & Prevent Med, Sackler Fac Med, Tel Aviv, Israel.4 aut |
700 | 1 | a Goltzman, Davidu McGill Univ, Dept Med, Montreal, PQ, Canada.;McGill Univ Hlth Ctr, Montreal, PQ, Canada.4 aut |
700 | 1 | a Gudnason, Vilmunduru Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Reykjavik, Iceland.4 aut |
700 | 1 | a Hall, Jillu Univ Edinburgh, MRC Ctr Reprod Hlth, Edinburgh, Midlothian, Scotland.4 aut |
700 | 1 | a Hans, Didieru Lausanne Univ Hosp CHUV, Bone & Joint Dept, Interdisciplinary Ctr Bone Dis, Lausanne, Switzerland.;Univ Lausanne, Lausanne, Switzerland.4 aut |
700 | 1 | a Hoff, Mariu Norwegian Univ Sci & Technol, Dept Neuromed & Movement Sci, Trondheim, Norway.;St Olavs Hosp, Dept Rheumatol, Trondheim, Norway.4 aut |
700 | 1 | a Hollick, Rosemary J.u Univ Aberdeen, Epidemiol Grp, Aberdeen Ctr Arthrit & Musculoskeletal Hlth, Aberdeen, Scotland.4 aut |
700 | 1 | a Huisman, Martijnu Vrije Univ Amsterdam Med Ctr, Amsterdam Publ Hlth Res Inst, Dept Epidemiol & Data Sci, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Dept Sociol, Amsterdam, Netherlands.4 aut |
700 | 1 | a Iki, Masayukiu Kindai Univ, Fac Med, Dept Publ Hlth, Osaka, Japan.4 aut |
700 | 1 | a Ish-Shalom, Sophiau Elisha Hosp, Endocrine Clin, Haifa, Israel.4 aut |
700 | 1 | a Jones, Graemeu Univ Tasmania, Menzies Inst Med Res, Hobart, Tas, Australia.4 aut |
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700 | 1 | a Rivadeneira, Fernandou Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.4 aut |
700 | 1 | a Schott, Anne-Marieu Univ Claude Bernard Lyon 1, INSERM, U1290, RESHAPE, Lyon, France.4 aut |
700 | 1 | a Shiroma, Eric J.u NIA, Lab Epidemiol & Populat Sci, Baltimore, MD 21224 USA.4 aut |
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700 | 1 | a Sornay-Rendu, Elisabethu Univ Claude Bernard Lyon1, Hop Edouard Herriot, INSERM, UMR 1033, Lyon, France.4 aut |
700 | 1 | a Sund, Reijou Univ Eastern Finland, Kuopio Musculoskeletal Res Unit, Kuopio, Finland.4 aut |
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700 | 1 | a Szulc, Pawelu Univ Claude Bernard Lyon1, Hop Edouard Herriot, INSERM, UMR 1033, Lyon, France.4 aut |
700 | 1 | a Tamaki, Junkou Osaka Med & Pharmaceut Univ, Dept Hyg & Publ Hlth, Fac Med, Educ Fdn, Osaka, Japan.4 aut |
700 | 1 | a Torgerson, David J.u Univ York, Dept Hlth Sci, York Trials Unit, York, N Yorkshire, England.4 aut |
700 | 1 | a van Schoor, Natasja M.u Vrije Univ Amsterdam Med Ctr, Amsterdam Publ Hlth Res Inst, Dept Epidemiol & Data Sci, Amsterdam, Netherlands.4 aut |
700 | 1 | a van Staa, Tjeerd P.u Univ Manchester, Sch Hlth Sci, Ctr Hlth Informat, Fac Biol Med & Hlth, Manchester, Lancs, England.4 aut |
700 | 1 | a Vila, Joanu Hosp del Mar Med Res Inst, Stat Support Unit, CIBER Epidemiol & Publ Hlth CIBERESP, Barcelona, Spain.4 aut |
700 | 1 | a Wareham, Nicholas J.u Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.4 aut |
700 | 1 | a Wright, Nicole C.u Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL USA.4 aut |
700 | 1 | a Yoshimura, Norikou Univ Tokyo Hosp, Dept Prevent Med Locomot Organ Disorders, Tokyo, Japan.4 aut |
700 | 1 | a Zillikens, MCarolau Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.4 aut |
700 | 1 | a Zwart, Martau PRECIOSA Fdn Invest, Barcelona, Spain.;Catalan Inst Hlth, Hlth Ctr Can Gibert del Pla, Girona, Spain.;Univ Girona, Dept Med Sci, Girona, Spain.;Inst Univ Invest Atencio Primaria Jordi Gol, Unitat Suport Recerca Girona, GROIMAP GROICAP Res Grp, Girona, Spain.4 aut |
700 | 1 | a Harvey, Nicholas C.u Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, Hants, England.;Univ Southampton, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England.;Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England.4 aut |
700 | 1 | a Lorentzon, Mattias,d 1970u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Australian Catholic Univ, Mary McKillop Inst Hlth Res, Melbourne, Vic, Australia.;Univ Gothenburg, Sahlgrenska Acad, Sahlgrenska Osteoporosis Ctr, Dept Internal Med & Clin Nutr,Inst Med, Gothenburg, Sweden.;Reg Vastra Gotaland, Sahlgrenska Univ Hosp, Geriatr Med, Mölndal, Sweden.4 aut0 (Swepub:gu)xlomat |
700 | 1 | a Leslie, William D.u Univ Manitoba, Dept Med, Winnipeg, MB, Canada.,University of Manitoba4 aut |
700 | 1 | a Kanis, John A.u Australian Catholic Univ, Mary McKillop Inst Hlth Res, Melbourne, Vic, Australia.;Univ Sheffield, Ctr Metab Bone Dis, Sheffield, S Yorkshire, England.,University of Sheffield4 aut |
710 | 2 | a Australian Catholic Univ, Mary McKillop Inst Hlth Res, Melbourne, Vic, Australia.b Australian Catholic University4 org |
773 | 0 | t Osteoporosis Internationald : Springerg 35:3, s. 469-494q 35:3<469-494x 0937-941Xx 1433-2965 |
856 | 4 | u http://dx.doi.org/10.1007/s00198-023-07012-1y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-533514 |
856 | 4 8 | u https://doi.org/10.1007/s00198-023-07012-1 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-50299 |
856 | 4 8 | u https://gup.ub.gu.se/publication/334362 |
856 | 4 8 | u https://lup.lub.lu.se/record/8339f7a6-a301-4806-ada7-2fcf28536d07 |
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