Sökning: WFRF:(Chiu Brian C H) > Genome-wide Associa...
Fältnamn | Indikatorer | Metadata |
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000 | 07507naa a2201705 4500 | |
001 | oai:lup.lub.lu.se:53e478f7-2858-4371-9919-59c067c00ed9 | |
003 | SwePub | |
008 | 160401s2014 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:129828674 | |
009 | oai:DiVA.org:uu-235614 | |
024 | 7 | a https://lup.lub.lu.se/record/47382862 URI |
024 | 7 | a https://doi.org/10.1016/j.ajhg.2014.09.0042 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1298286742 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2356142 URI |
040 | a (SwePub)lud (SwePub)kid (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Skibola, Christine F4 aut |
245 | 1 0 | a Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region. |
264 | 1 | b Elsevier BV,c 2014 |
520 | a Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10(-20)) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10(-11)) near ETS1; 3q28 (rs6444305, p = 1.10 × 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10(-10)) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10(-8)) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRβ1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (pomnibus = 4.20 × 10(-67) to 2.67 × 10(-70)). Additional independent signals included rs17203612 in HLA class II (odds ratio [ORper-allele] = 1.44; p = 4.59 × 10(-16)) and rs3130437 in HLA class I (ORper-allele = 1.23; p = 8.23 × 10(-9)). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Berndt, Sonja I4 aut |
700 | 1 | a Vijai, Joseph4 aut |
700 | 1 | a Conde, Lucia4 aut |
700 | 1 | a Wang, Zhaoming4 aut |
700 | 1 | a Yeager, Meredith4 aut |
700 | 1 | a de Bakker, Paul I W4 aut |
700 | 1 | a Birmann, Brenda M4 aut |
700 | 1 | a Vajdic, Claire M4 aut |
700 | 1 | a Foo, Jia-Nee4 aut |
700 | 1 | a Bracci, Paige M4 aut |
700 | 1 | a Vermeulen, Roel C H4 aut |
700 | 1 | a Slager, Susan L4 aut |
700 | 1 | a de Sanjose, Silvia4 aut |
700 | 1 | a Wang, Sophia S4 aut |
700 | 1 | a Linet, Martha S4 aut |
700 | 1 | a Salles, Gilles4 aut |
700 | 1 | a Lan, Qing4 aut |
700 | 1 | a Severi, Gianluca4 aut |
700 | 1 | a Hjalgrim, Henriku Karolinska Institutet4 aut |
700 | 1 | a Lightfoot, Tracy4 aut |
700 | 1 | a Melbye, Mads4 aut |
700 | 1 | a Gu, Jian4 aut |
700 | 1 | a Ghesquières, Hervé4 aut |
700 | 1 | a Link, Brian K4 aut |
700 | 1 | a Morton, Lindsay M4 aut |
700 | 1 | a Holly, Elizabeth A4 aut |
700 | 1 | a Smith, Alex4 aut |
700 | 1 | a Tinker, Lesley F4 aut |
700 | 1 | a Teras, Lauren R4 aut |
700 | 1 | a Kricker, Anne4 aut |
700 | 1 | a Becker, Nikolaus4 aut |
700 | 1 | a Purdue, Mark P4 aut |
700 | 1 | a Spinelli, John J4 aut |
700 | 1 | a Zhang, Yawei4 aut |
700 | 1 | a Giles, Graham G4 aut |
700 | 1 | a Vineis, Paolo4 aut |
700 | 1 | a Monnereau, Alain4 aut |
700 | 1 | a Bertrand, Kimberly A4 aut |
700 | 1 | a Albanes, Demetrius4 aut |
700 | 1 | a Zeleniuch-Jacquotte, Anne4 aut |
700 | 1 | a Gabbas, Attilio4 aut |
700 | 1 | a Chung, Charles C4 aut |
700 | 1 | a Burdett, Laurie4 aut |
700 | 1 | a Hutchinson, Amy4 aut |
700 | 1 | a Lawrence, Charles4 aut |
700 | 1 | a Montalvan, Rebecca4 aut |
700 | 1 | a Liang, Liming4 aut |
700 | 1 | a Huang, Jinyan4 aut |
700 | 1 | a Ma, Baoshan4 aut |
700 | 1 | a Liu, Jianjun4 aut |
700 | 1 | a Adami, Hans-Olov4 aut |
700 | 1 | a Glimelius, Bengtu Uppsala universitet,Enheten för onkologi4 aut0 (Swepub:uu)bengglim |
700 | 1 | a Ye, Yuanqing4 aut |
700 | 1 | a Nowakowski, Grzegorz S4 aut |
700 | 1 | a Dogan, Ahmet4 aut |
700 | 1 | a Thompson, Carrie A4 aut |
700 | 1 | a Habermann, Thomas M4 aut |
700 | 1 | a Novak, Anne J4 aut |
700 | 1 | a Liebow, Mark4 aut |
700 | 1 | a Witzig, Thomas E4 aut |
700 | 1 | a Weiner, George J4 aut |
700 | 1 | a Schenk, Maryjean4 aut |
700 | 1 | a Hartge, Patricia4 aut |
700 | 1 | a De Roos, Anneclaire J4 aut |
700 | 1 | a Cozen, Wendy4 aut |
700 | 1 | a Zhi, Degui4 aut |
700 | 1 | a Akers, Nicholas K4 aut |
700 | 1 | a Riby, Jacques4 aut |
700 | 1 | a Smith, Martyn T4 aut |
700 | 1 | a Lacher, Mortimer4 aut |
700 | 1 | a Villano, Danylo J4 aut |
700 | 1 | a Maria, Ann4 aut |
700 | 1 | a Roman, Eve4 aut |
700 | 1 | a Kane, Eleanoru Karolinska Institutet4 aut |
700 | 1 | a Jackson, Rebecca D4 aut |
700 | 1 | a North, Kari E4 aut |
700 | 1 | a Diver, W Ryan4 aut |
700 | 1 | a Turner, Jenny4 aut |
700 | 1 | a Armstrong, Bruce K4 aut |
700 | 1 | a Benavente, Yolanda4 aut |
700 | 1 | a Boffetta, Paolo4 aut |
700 | 1 | a Brennan, Paul4 aut |
700 | 1 | a Foretova, Lenka4 aut |
700 | 1 | a Maynadie, Marc4 aut |
700 | 1 | a Staines, Anthony4 aut |
700 | 1 | a McKay, James4 aut |
700 | 1 | a Brooks-Wilson, Angela R4 aut |
700 | 1 | a Zheng, Tongzhang4 aut |
700 | 1 | a Holford, Theodore R4 aut |
700 | 1 | a Chamosa, Saioa4 aut |
700 | 1 | a Kaaks, Rudolph4 aut |
700 | 1 | a Kelly, Rachel S4 aut |
700 | 1 | a Ohlsson, Bodilu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)kir-boh |
700 | 1 | a Travis, Ruth C4 aut |
700 | 1 | a Weiderpass, Elisabeteu Karolinska Institutet4 aut |
700 | 1 | a Clavel, Jacqueline4 aut |
700 | 1 | a Giovannucci, Edward4 aut |
700 | 1 | a Kraft, Peter4 aut |
700 | 1 | a Virtamo, Jarmo4 aut |
700 | 1 | a Mazza, Patrizio4 aut |
700 | 1 | a Cocco, Pierluigi4 aut |
700 | 1 | a Ennas, Maria Grazia4 aut |
700 | 1 | a Chiu, Brian C H4 aut |
700 | 1 | a Fraumeni, Joseph F4 aut |
700 | 1 | a Nieters, Alexandra4 aut |
700 | 1 | a Offit, Kenneth4 aut |
700 | 1 | a Wu, Xifeng4 aut |
700 | 1 | a Cerhan, James R4 aut |
700 | 1 | a Smedby, Karin E4 aut |
700 | 1 | a Chanock, Stephen J4 aut |
700 | 1 | a Rothman, Nathaniel4 aut |
710 | 2 | a Karolinska Institutetb Enheten för onkologi4 org |
773 | 0 | t American Journal of Human Geneticsd : Elsevier BVg 95:4, s. 462-471q 95:4<462-471x 0002-9297x 1537-6605 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/25279986?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1016/j.ajhg.2014.09.004y FULLTEXT |
856 | 4 | u http://www.cell.com/article/S0002929714003875/pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/4738286 |
856 | 4 8 | u https://doi.org/10.1016/j.ajhg.2014.09.004 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:129828674 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-235614 |
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