WFRF:(Clinton D)
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Synthesis and alpha-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis
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- Cumpstey, Ian (author)
- Stockholms universitet,Institutionen för organisk kemi
- Ramstadius, Clinton (author)
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- Borbas, K. Eszter (author)
- Stockholms universitet,Institutionen för organisk kemi
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- Alonzi, Dominic S. (author)
- Butters, Terry D. (author)
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- (creator_code:org_t)
- Elsevier BV, 2011
- 2011
- English.
- In: Bioorganic & Medicinal Chemistry Letters. - : Elsevier BV. - 0960-894X .- 1464-3405. ; 21:18, s. 5219-5223
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Valienol-derived allylic C-1 bromides have been used as carbaglycosyl donors for alpha-xylo configured valienamine pseudodisaccharide synthesis. We synthesised valienamine analogues of the Glc(alpha 1 -> 3)Glc and Glc(alpha 1 -> 3) Man disaccharides representing the linkages cleaved by alpha-Glucosidase II in N-glycan biosynthesis. These (N1 -> 3)-linked pseudodisaccharides were found to have some alpha-Glucosidase II inhibitory activity, while two other (N1 -> 6)-linked valienamine pseudodisaccharides failed to inhibit the enzyme. (C)
Keyword
- alpha-Glucosidase II
- Glycosidase inhibitors
- Valienamine
- Pseudodisaccharides
- N-Glycans
Publication and Content Type
- ref (subject category)
- art (subject category)
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