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  • Giese, Anne KatrinBroad Institute,Massachusetts General Hospital (author)

Design and rationale for examining neuroimaging genetics in ischemic stroke : The MRI-GENIE study

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:6c8b5eaf-dceb-48d6-b084-bebfddbf1220
  • https://lup.lub.lu.se/record/6c8b5eaf-dceb-48d6-b084-bebfddbf1220URI
  • https://doi.org/10.1212/NXG.0000000000000180DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Objective: To describe the design and rationale for the genetic analysis of acute and chronic cerebrovascular neuroimaging phenotypes detected on clinical MRI in patients with acute ischemic stroke (AIS) within the scope of the MRI-GENetics Interface Exploration (MRI-GENIE) study. Methods: MRI-GENIE capitalizes on the existing infrastructure of the Stroke Genetics Network (SiGN). In total, 12 international SiGN sites contributedMRIs of 3,301 patients with AIS. Detailed clinical phenotyping with the web-based Causative Classification of Stroke (CCS) system and genome-wide genotyping data were available for all participants. Neuroimaging analyses include themanual and automated assessments of established MRI markers. A high-throughputMRI analysis pipeline for the automated assessment of cerebrovascular lesions on clinical scans will be developed in a subset of scans for both acute and chronic lesions, validated against gold standard, and applied to all available scans. The extracted neuroimaging phenotypes will improve characterization of acute and chronic cerebrovascular lesions in ischemic stroke, including CCS subtypes, and their effect on functional outcomes after stroke. Moreover, genetic testing will uncover variants associated with acute and chronic MRI manifestations of cerebrovascular disease.Conclusions: The MRI-GENIE study aims to develop, validate, and distribute the MRI analysis platform for scans acquired as part of clinical care for patients with AIS, which will lead to (1) novel genetic discoveries in ischemic stroke, (2) strategies for personalized stroke risk assessment, and (3) personalized stroke outcome assessment.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Schirmer, Markus D.Massachusetts Institute of Technology,Massachusetts General Hospital (author)
  • Donahue, Kathleen L.Massachusetts General Hospital (author)
  • Cloonan, LisaMassachusetts General Hospital (author)
  • Irie, RobertMassachusetts General Hospital (author)
  • Winzeck, StefanMassachusetts General Hospital (author)
  • Bouts, Mark J.R.J.Massachusetts General Hospital (author)
  • McIntosh, Elissa C.Massachusetts General Hospital (author)
  • Mocking, Steven J.Massachusetts General Hospital (author)
  • Dalca, Adrian V.Massachusetts Institute of Technology,Massachusetts General Hospital (author)
  • Sridharan, RameshMedical University of Graz (author)
  • Xu, HuichunUniversity of Maryland, Baltimore (author)
  • Frid, PetreaLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-ptf (author)
  • Giralt-Steinhauer, EvaAutonomous University of Barcelona (author)
  • Holmegaard, LukasSahlgrenska Academy (author)
  • Roquer, JaumeMassachusetts General Hospital,Broad Institute (author)
  • Wasselius, JohanLund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neuroradiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)oft-jws (author)
  • Cole, John W.University of Maryland, Baltimore (author)
  • McArdle, Patrick F.University of Maryland, Baltimore (author)
  • Broderick, Joseph P.University of Cincinnati (author)
  • Jimenez-Conde, JordiAutonomous University of Barcelona (author)
  • Jern, ChristinaSahlgrenska Academy (author)
  • Kissela, Brett M.University of Cincinnati (author)
  • Kleindorfer, Dawn O.University of Cincinnati (author)
  • Lemmens, RobinUniversity Hospitals Leuven,Catholic University of Leuven,Flanders Interuniversity Institute for Biotechnology (author)
  • Lindgren, ArneLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)neur-ali (author)
  • Meschia, James F.Mayo Clinic Minnesota (author)
  • Rundek, TatjanaUniversity of Miami (author)
  • Sacco, Ralph L.Massachusetts General Hospital (author)
  • Schmidt, ReinholdMassachusetts Institute of Technology (author)
  • Sharma, PankajAshford And St Peter's Hospital,Royal Holloway University of London (author)
  • Slowik, AgnieszkaJagiellonian University (author)
  • Thijs, VincentAustin Health,Florey Institute of Neuroscience and Mental Health (author)
  • Woo, DanielUniversity of Cincinnati (author)
  • Worrall, Bradford B.University of Virginia (author)
  • Kittner, Steven J.University of Maryland, Baltimore (author)
  • Mitchell, Braxton D.Veterans Health Administration,University of Maryland, Baltimore (author)
  • Rosand, JonathanAutonomous University of Barcelona (author)
  • Golland, PolinaMassachusetts Institute of Technology (author)
  • Wu, OnaMassachusetts General Hospital (author)
  • Rost, Natalia S.Massachusetts General Hospital (author)
  • Broad InstituteMassachusetts General Hospital (creator_code:org_t)

Related titles

  • In:Neurology: Genetics3:52376-7839

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