Sökning: WFRF:(Curtin K) > Genome-wide associa...
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000 | 07617naa a2201861 4500 | |
001 | oai:DiVA.org:uu-207028 | |
003 | SwePub | |
008 | 130909s2013 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:127126091 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2070282 URI |
024 | 7 | a https://doi.org/10.1038/ng.26522 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1271260912 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Berndt, Sonja I.4 aut |
245 | 1 0 | a Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia |
264 | c 2013-06-16 | |
264 | 1 | b Springer Science and Business Media LLC,c 2013 |
338 | a print2 rdacarrier | |
520 | a Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 x 10(-14)), 18q21.33 (BCL2, P = 7.76 x 10(-11)), 11p15.5 (C11orf21, P = 2.15 x 10(-10)), 4q25 (LEF1, P = 4.24 x 10(-10)), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 x 10(-9)), 9p21.3 (CDKN2B-AS1, P = 1.27 x 10(-8)), 18q21.32 (PMAIP1, P = 2.51 x 10(-8)), 15q15.1 (BMF, P = 2.71 x 10(-10)) and 2p22.2 (QPCT, P = 1.68 x 10(-8)), as well as an independent signal at an established locus (2q13, ACOXL, P = 2.08 x 10(-18)). We also found evidence for two additional promising loci below genome-wide significance at 8q22.3 (ODF1, P = 5.40 x 10(-8)) and 5p15.33 (TERT, P = 1.92 x 10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism. | |
700 | 1 | a Skibola, Christine F.4 aut |
700 | 1 | a Joseph, Vijai4 aut |
700 | 1 | a Camp, Nicola J.4 aut |
700 | 1 | a Nieters, Alexandra4 aut |
700 | 1 | a Wang, Zhaoming4 aut |
700 | 1 | a Cozen, Wendy4 aut |
700 | 1 | a Monnereau, Alain4 aut |
700 | 1 | a Wang, Sophia S.4 aut |
700 | 1 | a Kelly, Rachel S.4 aut |
700 | 1 | a Lan, Qing4 aut |
700 | 1 | a Teras, Lauren R.4 aut |
700 | 1 | a Chatterjee, Nilanjan4 aut |
700 | 1 | a Chung, Charles C.4 aut |
700 | 1 | a Yeager, Meredith4 aut |
700 | 1 | a Brooks-Wilson, Angela R.4 aut |
700 | 1 | a Hartge, Patricia4 aut |
700 | 1 | a Purdue, Mark P.4 aut |
700 | 1 | a Birmann, Brenda M.4 aut |
700 | 1 | a Armstrong, Bruce K.4 aut |
700 | 1 | a Cocco, Pierluigi4 aut |
700 | 1 | a Zhang, Yawei4 aut |
700 | 1 | a Severi, Gianluca4 aut |
700 | 1 | a Zeleniuch-Jacquotte, Anne4 aut |
700 | 1 | a Lawrence, Charles4 aut |
700 | 1 | a Burdette, Laurie4 aut |
700 | 1 | a Yuenger, Jeffrey4 aut |
700 | 1 | a Hutchinson, Amy4 aut |
700 | 1 | a Jacobs, Kevin B.4 aut |
700 | 1 | a Call, Timothy G.4 aut |
700 | 1 | a Shanafelt, Tait D.4 aut |
700 | 1 | a Novak, Anne J.4 aut |
700 | 1 | a Kay, Neil E.4 aut |
700 | 1 | a Liebow, Mark4 aut |
700 | 1 | a Wang, Alice H.4 aut |
700 | 1 | a Smedby, Karin E.u Karolinska Institutet4 aut |
700 | 1 | a Adami, Hans-Olovu Karolinska Institutet4 aut |
700 | 1 | a Melbye, Mads4 aut |
700 | 1 | a Glimelius, Bengtu Uppsala universitet,Enheten för onkologi4 aut0 (Swepub:uu)bengglim |
700 | 1 | a Chang, Ellen T.4 aut |
700 | 1 | a Glenn, Martha4 aut |
700 | 1 | a Curtin, Karen4 aut |
700 | 1 | a Cannon-Albright, Lisa A.4 aut |
700 | 1 | a Jones, Brandt4 aut |
700 | 1 | a Diver, W. Ryan4 aut |
700 | 1 | a Link, Brian K.4 aut |
700 | 1 | a Weiner, George J.4 aut |
700 | 1 | a Conde, Lucia4 aut |
700 | 1 | a Bracci, Paige M.4 aut |
700 | 1 | a Riby, Jacques4 aut |
700 | 1 | a Holly, Elizabeth A.4 aut |
700 | 1 | a Smith, Martyn T.4 aut |
700 | 1 | a Jackson, Rebecca D.4 aut |
700 | 1 | a Tinker, Lesley F.4 aut |
700 | 1 | a Benavente, Yolanda4 aut |
700 | 1 | a Becker, Nikolaus4 aut |
700 | 1 | a Boffetta, Paolo4 aut |
700 | 1 | a Brennan, Paul4 aut |
700 | 1 | a Foretova, Lenka4 aut |
700 | 1 | a Maynadie, Marc4 aut |
700 | 1 | a McKay, James4 aut |
700 | 1 | a Staines, Anthony4 aut |
700 | 1 | a Rabe, Kari G.4 aut |
700 | 1 | a Achenbach, Sara J.4 aut |
700 | 1 | a Vachon, Celine M.4 aut |
700 | 1 | a Goldin, Lynn R.4 aut |
700 | 1 | a Strom, Sara S.4 aut |
700 | 1 | a Lanasa, Mark C.4 aut |
700 | 1 | a Spector, Logan G.4 aut |
700 | 1 | a Leis, Jose F.4 aut |
700 | 1 | a Cunningham, Julie M.4 aut |
700 | 1 | a Weinberg, J. Brice4 aut |
700 | 1 | a Morrison, Vicki A.4 aut |
700 | 1 | a Caporaso, Neil E.4 aut |
700 | 1 | a Norman, Aaron D.4 aut |
700 | 1 | a Linet, Martha S.4 aut |
700 | 1 | a De Roos, Anneclaire J.4 aut |
700 | 1 | a Morton, Lindsay M.4 aut |
700 | 1 | a Severson, Richard K.4 aut |
700 | 1 | a Riboli, Elio4 aut |
700 | 1 | a Vineis, Paolo4 aut |
700 | 1 | a Kaaks, Rudolph4 aut |
700 | 1 | a Trichopoulos, Dimitrios4 aut |
700 | 1 | a Masala, Giovanna4 aut |
700 | 1 | a Weiderpass, Elisabeteu Karolinska Institutet4 aut |
700 | 1 | a Chirlaque, Mara-Dolores4 aut |
700 | 1 | a Vermeulen, Roel C. H.4 aut |
700 | 1 | a Travis, Ruth C.4 aut |
700 | 1 | a Giles, Graham G.4 aut |
700 | 1 | a Albanes, Demetrius4 aut |
700 | 1 | a Virtamo, Jarmo4 aut |
700 | 1 | a Weinstein, Stephanie4 aut |
700 | 1 | a Clavel, Jacqueline4 aut |
700 | 1 | a Zheng, Tongzhang4 aut |
700 | 1 | a Holford, Theodore R.4 aut |
700 | 1 | a Offit, Kenneth4 aut |
700 | 1 | a Zelenetz, Andrew4 aut |
700 | 1 | a Klein, Robert J.4 aut |
700 | 1 | a Spinelli, John J.4 aut |
700 | 1 | a Bertrand, Kimberly A.4 aut |
700 | 1 | a Laden, Francine4 aut |
700 | 1 | a Giovannucci, Edward4 aut |
700 | 1 | a Kraft, Peter4 aut |
700 | 1 | a Kricker, Anne4 aut |
700 | 1 | a Turner, Jenny4 aut |
700 | 1 | a Vajdic, Claire M.4 aut |
700 | 1 | a Ennas, Maria Grazia4 aut |
700 | 1 | a Ferri, Giovanni M.4 aut |
700 | 1 | a Miligi, Lucia4 aut |
700 | 1 | a Liang, Liming4 aut |
700 | 1 | a Sampson, Joshua4 aut |
700 | 1 | a Crouch, Simon4 aut |
700 | 1 | a Park, Ju-Hyun4 aut |
700 | 1 | a North, Kari E.4 aut |
700 | 1 | a Cox, Angela4 aut |
700 | 1 | a Snowden, John A.4 aut |
700 | 1 | a Wright, Josh4 aut |
700 | 1 | a Carracedo, Angel4 aut |
700 | 1 | a Lopez-Otin, Carlos4 aut |
700 | 1 | a Bea, Silvia4 aut |
700 | 1 | a Salaverria, Itziar4 aut |
700 | 1 | a Martin-Garcia, David4 aut |
700 | 1 | a Campo, Elias4 aut |
700 | 1 | a Fraumeni, Joseph F., Jr.4 aut |
700 | 1 | a de Sanjose, Silvia4 aut |
700 | 1 | a Hjalgrim, Henrik4 aut |
700 | 1 | a Cerhan, James R.4 aut |
700 | 1 | a Chanock, Stephen J.4 aut |
700 | 1 | a Rothman, Nathaniel4 aut |
700 | 1 | a Slager, Susan L.4 aut |
710 | 2 | a Karolinska Institutetb Enheten för onkologi4 org |
773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 45:8, s. 868-U202q 45:8<868-U202x 1061-4036x 1546-1718 |
856 | 4 | u https://europepmc.org/articles/pmc3729927?pdf=render |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-207028 |
856 | 4 8 | u https://doi.org/10.1038/ng.2652 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:127126091 |
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