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Sökning: WFRF:(De Jong Frank Jan) > (2015-2019) > Long-Term Cognitive...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004634naa a2200625 4500
001oai:lup.lub.lu.se:b84c49d3-e277-4088-87cc-70029d0304cb
003SwePub
008170502s2017 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:135723209
0247 a https://lup.lub.lu.se/record/b84c49d3-e277-4088-87cc-70029d0304cb2 URI
0247 a https://doi.org/10.3233/JAD-1611092 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1357232092 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Kramberger, Milica G.u Karolinska Institute4 aut
2451 0a Long-Term Cognitive Decline in Dementia with Lewy Bodies in a Large Multicenter, International Cohort
264 1c 2017
300 a 9 s.
520 a Background/Objective: The aim of this study was to describe the rate and clinical predictors of cognitive decline in dementia with Lewy bodies (DLB), and compare the findings with Alzheimer's disease (AD) and Parkinson's disease dementia (PDD) patients. Methods: Longitudinal scores for the Mini-Mental State Examination (MMSE) in 1,290 patients (835 DLB, 198 PDD, and 257 AD) were available from 18 centers with up to three years longitudinal data. Linear mixed effects analyses with appropriate covariates were used to model MMSE decline over time. Several subgroup analyses were performed, defined by anti-dementia medication use, baseline MMSE score, and DLB core features. Results: The mean annual decline in MMSE score was 2.1 points in DLB, compared to 1.6 in AD (p=0.07 compared to DLB) and 1.8 in PDD (p=0.19). Rates of decline were significantly higher in DLB compared to AD and PDD when baseline MMSE score was included as a covariate, and when only those DLB patients with an abnormal dopamine transporter SPECT scan were included. Decline was not predicted by sex, baseline MMSE score, or presence of specific DLB core features. Conclusions: The average annual decline in MMSE score in DLB is approximately two points. Although in the overall analyses there were no differences in the rate of decline between the three neurodegenerative disorders, there were indications of a more rapid decline in DLB than in AD and PDD. Further studies are needed to understand the predictors and mechanisms of cognitive decline in DLB.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a Dementia with Lewy bodies
653 a international cohort
653 a long-term cognitive decline
653 a multicenter study
7001 a Auestad, Bjørnu Stavanger University Hospital4 aut
7001 a Garcia-Ptacek, Sarau Karolinska Institutet,Karolinska Institute4 aut
7001 a Abdelnour, Carlau Barcelona Alzheimer Treatment & Research Center4 aut
7001 a Olmo, Josep Garreu Girona Biomedical Research Institute (IDIBGI)4 aut
7001 a Walker, Zuzanau University College London4 aut
7001 a Lemstra, Afina W.u Amsterdam UMC - Vrije Universiteit Amsterdam4 aut
7001 a Londos, Elisabetu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)pski-elo
7001 a Blanc, Fredericu University of Strasbourg4 aut
7001 a Bonanni, Laurau University G.d'Annunzio of Chieti-Pescara4 aut
7001 a McKeith, Ian Gu University of Cambridge4 aut
7001 a Winblad, Bengtu Karolinska Institutet,Karolinska Institute4 aut
7001 a De Jong, Frank Janu Erasmus University Medical Center4 aut
7001 a Nobili, Flaviou University of Genoa4 aut
7001 a Stefanova, Elka4 aut
7001 a Petrova, Maria4 aut
7001 a Falup-Pecurariu, Cristian4 aut
7001 a Rektorova, Irena4 aut
7001 a Bostantjopoulou, Sevasti4 aut
7001 a Biundo, Roberta4 aut
7001 a Weintraub, Daniel4 aut
7001 a Aarsland, Dagu Karolinska Institutet4 aut
7102 a Karolinska Instituteb Stavanger University Hospital4 org
7730 t Journal of Alzheimer's Diseaseg 57:3, s. 787-795q 57:3<787-795x 1387-2877x 1875-8908
8564 u http://dx.doi.org/10.3233/JAD-161109y FULLTEXT
8564 8u https://lup.lub.lu.se/record/b84c49d3-e277-4088-87cc-70029d0304cb
8564 8u https://doi.org/10.3233/JAD-161109
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:135723209

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