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  • Martínez-Sánchez, NoeliaDepartment of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain (författare)

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • Cambridge, MA, United States :Cell Press,2017
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-59392
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-59392URI
  • https://doi.org/10.1016/j.cmet.2017.06.014DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:European Community, Projektnr. 260464, 281854Xunta de Galicia, Projektnr. ED431C-2016-025, ED341D-R2016-032, 2015-CP080,  2016-PG057, 2015-CP079, 2016-PG068, ED481A-2016/094, 2016-2019,  ED431G/05 Junta de Andalucia, Projektnr. P12-FQM-01943Gobierno Vasco-Departamento de Salud, Projektnr. 2013111114EITB, Projektnr. BIO15/CA/014Ayudas para apoyar grupos de investigacion del sistema Universitario Vasco, Projektnr. IT971-16Generalitat de Catalunya, Projektnr. 2014SGR465Fundacio La Marato de TV3, Projektnr. 87/C/2016Instituto de Salud Carlos III - FEDER, Projektnr. RD16/0008/ 0003, PIE14/00031Ministerio de Economia y Competitividad (MINECO) - FEDER Program of EU, Projektnr. SAF2014-52223-C2-2-R, BFU2014-57581-P -P, BFU2013-44229-R, BFU2014-55871-P, SAF2014-54658-R, SAF2015-64352-R, BFU2015-70664R, SAF2013-43506-R, SAF2014 55725, SAF2015-71026-R, BFU2015-70454-REDT/Adipoplast  Asociacion Espanola contra el CancerMedical Research Council (MRC) Metabolic Diseases Unit, Projektnr. MRC_MC_UU_12012/1, MRC_UU_12015/5 MRC Programme Grant, Projektnr. G9824984MRC Disease Model CoreDeutsche Forschungsgemeinschaft, Projektnr. Mi1242/2-1American Heart Association (EIA), Projektnr. 14EIA18860041University of Iowa Fraternal Order of Eagles Diabetes Research CenterEuropean Foundation for the Study of DiabetesAtresmedia CorporacionISCIII , Projektnr. CD14/0007, CP12/03121MINECO, Projektnr. IJDC-2014-19681, BES-2015-072743, FPU12/01827, SEV-2015-0505AECC, Projektnr. AIO2013Pro-CNIC Foundation
  • Thyroid hormones (THs) act in the brain to modulate energy balance. We show that central triiodothyronine (T3) regulates de novo lipogenesis in liver and lipid oxidation in brown adipose tissue (BAT) through the parasympathetic (PSNS) and sympathetic nervous system (SNS), respectively. Central T3 promotes hepatic lipogenesis with parallel stimulation of the thermogenic program in BAT. The action of T3 depends on AMP-activated protein kinase (AMPK)-induced regulation of two signaling pathways in the ventromedial nucleus of the hypothalamus (VMH): decreased ceramide-induced endoplasmic reticulum (ER) stress, which promotes BAT thermogenesis, and increased c-Jun N-terminal kinase (JNK) activation, which controls hepatic lipid metabolism. Of note, ablation of AMPKα1 in steroidogenic factor 1 (SF1) neurons of the VMH fully recapitulated the effect of central T3, pointing to this population in mediating the effect of central THs on metabolism. Overall, these findings uncover the underlying pathways through which central T3 modulates peripheral metabolism.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Seoane-Collazo, PatriciaDepartment of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesid (författare)
  • Contreras, CristinaDepartment of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain (författare)
  • Varela, LuisDepartment of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain (författare)
  • Villarroya, JoanCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain; Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina, Universitat de Barcelona (IBUB), Barcelona, Spain; Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (författare)
  • Rial-Pensado, EvaDepartment of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain (författare)
  • Buqué, XabierDepartment of Physiology, University of the Basque Country UPV/EHU, Biocruces Research Institute, Barakaldo, Spain (författare)
  • Aurrekoetxea, IgorDepartment of Physiology, University of the Basque Country UPV/EHU, Biocruces Research Institute, Barakaldo, Spain (författare)
  • Delgado, Teresa C.CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Derio, Spain (författare)
  • Vázquez-Martínez, RafaelCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain; Instituto Maimónides de Investigación Biomédica (IMIBIC)/Hospital Universitario Reina Sofía, Córdoba, Spain (författare)
  • González-García, IsmaelDepartment of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain (författare)
  • Roa, JuanCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain; Instituto Maimónides de Investigación Biomédica (IMIBIC)/Hospital Universitario Reina Sofía, Córdoba, Spain (författare)
  • Whittle, Andrew J.University of Cambridge Metabolic Research Laboratories, MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK (författare)
  • Gomez-Santos, BeatrizDepartment of Physiology, University of the Basque Country UPV/EHU, Biocruces Research Institute, Barakaldo, Spain (författare)
  • Velagapudi, VidyaVTT Technical Research Centre of Finland, Espoo, Finland; Metabolomics Unit, Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland (författare)
  • Tung, Y. C. LoraineUniversity of Cambridge Metabolic Research Laboratories, MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK (författare)
  • Morgan, Donald A.Department of Pharmacology, University of Iowa, Iowa City, USA (författare)
  • Voshol, Peter J.University of Cambridge Metabolic Research Laboratories, MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK (författare)
  • Martínez de Morentin, Pablo B.Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain (författare)
  • López-González, TaniaDepartment of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain; Clinical Neurosciences Research Laboratory, Department of Neurology, Hospital Clínico Universitario, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain (författare)
  • Liñares-Pose, LauraDepartment of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain (författare)
  • Gonzalez, FranciscoDepartment of Surgery, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; Service of Ophthalmology, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain (författare)
  • Chatterjee, KrishnaUniversity of Cambridge Metabolic Research Laboratories, MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK (författare)
  • Sobrino, TomásClinical Neurosciences Research Laboratory, Department of Neurology, Hospital Clínico Universitario, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain (författare)
  • Medina-Gómez, GemaDepartment of Basic Sciences of Health, Area of Biochemistry and Molecular Biology, University Rey Juan Carlos, Madrid, Spain (författare)
  • Davis, Roger J.Program in Molecular Medicine, University of Massachusetts Medical School, Worcester MA, USA; Howard Hughes Medical Institute, Worcester MA, USA (författare)
  • Casals, NúriaCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain; Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Sant Cugat del Vallés, Barcelona, Spain (författare)
  • Oresic, Matej,1967-Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland(Swepub:oru)moc (författare)
  • Coll, Anthony P.University of Cambridge Metabolic Research Laboratories, MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK (författare)
  • Vidal-Puig, AntonioUniversity of Cambridge Metabolic Research Laboratories, MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK (författare)
  • Mittag, JensInternal Medicine I, Center of Brain, Behavior, and Metabolism (CBBM), University of Lübeck, Lübeck, Germany (författare)
  • Tena-Sempere, ManuelCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain; Instituto Maimónides de Investigación Biomédica (IMIBIC)/Hospital Universitario Reina Sofía, Córdoba, Spain; FiDiPro Program, Department of Physiology, University of Turku, Turku, Finland (författare)
  • Malagón, María M.CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain; Instituto Maimónides de Investigación Biomédica (IMIBIC)/Hospital Universitario Reina Sofía, Córdoba, Spain (författare)
  • Diéguez, CarlosDepartment of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain (författare)
  • Martínez-Chantar, María LuzCIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Technology Park of Bizkaia, Derio, Bizkaia, Spain (författare)
  • Aspichueta, PatriciaDepartment of Physiology, Biocruces Research Institute, Cruces University Hospital, University of the Basque Country UPV/EHU, Barakaldo, Spain (författare)
  • Rahmouni, KamalDepartment of Pharmacology, University of Iowa, Iowa City IA, USA; Department of Internal Medicine, University of Iowa, Iowa City IA, USA (författare)
  • Nogueiras, RubénDepartment of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain (författare)
  • Sabio, GuadalupeMyocardial Pathophysiology, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain (författare)
  • Villarroya, FrancescCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain; Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina, Universitat de Barcelona (IBUB), Barcelona, Spain (författare)
  • López, MiguelDepartment of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain (författare)
  • Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, SpainDepartment of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesid (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cell MetabolismCambridge, MA, United States : Cell Press26:1, s. 212-229.e121550-41311932-7420

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