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Advancing the public health applications of Chlamydia trachomatis serology

Woodhall, Sarah C. (författare)
Public Health England, London, UK; University of Bristol, Bristol, UK; University College London, London, UK
Gorwitz, Rachel J. (författare)
US Centers for Disease Control and Prevention, Atlanta GA, USA
Migchelsen, Stephanie J. (författare)
Public Health England, London, UK; London School of Hygiene & Tropical Medicine, London, UK
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Gottlieb, Sami L. (författare)
World Health Organization, Geneva, Switzerland
Horner, Patrick J. (författare)
University of Bristol, Bristol, UK
Geisler, William M. (författare)
University of Alabama, Birmingham AL, USA
Winstanley, Catherine (författare)
University of Southampton, Southampton, UK
Hufnagel, Katrin (författare)
German Cancer Research Center (DKFZ), Heidelberg, Germany
Waterboer, Tim (författare)
German Cancer Research Center (DKFZ), Heidelberg, Germany
Martin, Diana L. (författare)
US Centers for Disease Control and Prevention, Atlanta GA, USA
Huston, Wilhelmina M. (författare)
University of Technology Sydney, Sydney NSW, Australia
Gaydos, Charlotte A. (författare)
Johns Hopkins University, Baltimore MD, USA
Deal, Carolyn (författare)
National Institute of Health, Bethesda MD, USA
Unemo, Magnus, 1970- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,WHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, Örebro University Hospital, Örebro, Sweden
Dunbar, J. Kevin (författare)
Public Health England, London, UK; University of Bristol, Bristol, UK; University College London, London, UK
Bernstein, Kyle (författare)
US Centers for Disease Control and Prevention, Atlanta GA, USA
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 (creator_code:org_t)
Elsevier, 2018
2018
Engelska.
Ingår i: The Lancet - Infectious diseases. - : Elsevier. - 1473-3099 .- 1474-4457. ; 18:12, s. E399-E407
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
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  • Genital Chlamydia trachomatis infection is the most commonly diagnosed sexually transmitted infection. Trachoma is caused by ocular infection with C trachomatis and is the leading infectious cause of blindness worldwide. New serological assays for C trachomatis could facilitate improved understanding of C trachomatis epidemiology and prevention. C trachomatis serology offers a means of investigating the incidence of chlamydia infection and might be developed as a biomarker of scarring sequelae, such as pelvic inflammatory disease. Therefore, serological assays have potential as epidemiological tools to quantify unmet need, inform service planning, evaluate interventions including screening and treatment, and to assess new vaccine candidates. However, questions about the performance characteristics and interpretation of C trachomatis serological assays remain, which must be addressed to advance development within this field. In this Personal View, we explore the available information about C trachomatis serology and propose several priority actions. These actions involve development of target product profiles to guide assay selection and assessment across multiple applications and populations, establishment of a serum bank to facilitate assay development and evaluation, and development of technical and statistical methods for assay evaluation and analysis of serological findings. The field of C trachomatis serology will benefit from collaboration across the public health community to align technological developments with their potential applications.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

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