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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 11810naa a2202341 4500 | |
| 001 | oai:DiVA.org:uu-489540 | |
| 003 | SwePub | |
| 008 | 221201s2022 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:150459871 | |
| 009 | oai:lup.lub.lu.se:33b1be06-6bf7-43ac-a73c-1357fab4e5bf | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4895402 URI |
| 024 | 7 | a https://doi.org/10.1136/bjsports-2021-1051322 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1504598712 URI |
| 024 | 7 | a https://lup.lub.lu.se/record/33b1be06-6bf7-43ac-a73c-1357fab4e5bf2 URI |
| 040 | a (SwePub)uud (SwePub)kid (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Dixon-Suen, Suzanne Cu Cancer Council Victoria4 aut |
| 245 | 1 0 | a Physical activity, sedentary time and breast cancer risk :b a Mendelian randomisation study |
| 264 | c 2022-09-06 | |
| 264 | 1 | b BMJ Publishing Group Ltd,c 2022 |
| 338 | a print2 rdacarrier | |
| 520 | a OBJECTIVES: Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk overall, pre/post-menopause, and by case-groups defined by tumour characteristics.METHODS: We performed two-sample inverse-variance-weighted MR using individual-level Breast Cancer Association Consortium case-control data from 130 957 European-ancestry women (69 838 invasive cases), and published UK Biobank data (n=91 105-377 234). Genetic instruments were single nucleotide polymorphisms (SNPs) associated in UK Biobank with wrist-worn accelerometer-measured overall physical activity (nsnps=5) or sedentary time (nsnps=6), or accelerometer-measured (nsnps=1) or self-reported (nsnps=5) vigorous physical activity.RESULTS: Greater genetically-predicted overall activity was associated with lower breast cancer overall risk (OR=0.59; 95% confidence interval (CI) 0.42 to 0.83 per-standard deviation (SD;~8 milligravities acceleration)) and for most case-groups. Genetically-predicted vigorous activity was associated with lower risk of pre/perimenopausal breast cancer (OR=0.62; 95% CI 0.45 to 0.87,≥3 vs. 0 self-reported days/week), with consistent estimates for most case-groups. Greater genetically-predicted sedentary time was associated with higher hormone-receptor-negative tumour risk (OR=1.77; 95% CI 1.07 to 2.92 per-SD (~7% time spent sedentary)), with elevated estimates for most case-groups. Results were robust to sensitivity analyses examining pleiotropy (including weighted-median-MR, MR-Egger).CONCLUSION: Our study provides strong evidence that greater overall physical activity, greater vigorous activity, and lower sedentary time are likely to reduce breast cancer risk. More widespread adoption of active lifestyles may reduce the burden from the most common cancer in women. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
| 653 | a Breast | |
| 653 | a Genetics | |
| 653 | a Physical activity | |
| 653 | a Sedentary Behaviour | |
| 700 | 1 | a Lewis, Sarah J4 aut |
| 700 | 1 | a Martin, Richard M4 aut |
| 700 | 1 | a English, Dallas R4 aut |
| 700 | 1 | a Boyle, Terry4 aut |
| 700 | 1 | a Giles, Graham G4 aut |
| 700 | 1 | a Michailidou, Kyriaki4 aut |
| 700 | 1 | a Bolla, Manjeet K4 aut |
| 700 | 1 | a Wang, Qin4 aut |
| 700 | 1 | a Dennis, Joe4 aut |
| 700 | 1 | a Lush, Michael4 aut |
| 700 | 1 | a Investigators, Abctb4 aut |
| 700 | 1 | a Ahearn, Thomas U4 aut |
| 700 | 1 | a Ambrosone, Christine B4 aut |
| 700 | 1 | a Andrulis, Irene Lu Karolinska Institutet4 aut |
| 700 | 1 | a Anton-Culver, Hoda4 aut |
| 700 | 1 | a Arndt, Volker4 aut |
| 700 | 1 | a Aronson, Kristan J4 aut |
| 700 | 1 | a Augustinsson, A.u Lund University,Lunds universitet,Karolinska Institutet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Cancerepidemiologi & strål,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Biomarkörer och Epi,Institutionen för kliniska vetenskaper, Lund,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Cancerepidemiology and radiation,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Biomarkers and epidemiology,Department of Clinical Sciences, Lund4 aut0 (Swepub:lu)med-aea |
| 700 | 1 | a Auvinen, Päivi4 aut |
| 700 | 1 | a Beane Freeman, Laura E4 aut |
| 700 | 1 | a Becher, Heiko4 aut |
| 700 | 1 | a Beckmann, Matthias W4 aut |
| 700 | 1 | a Behrens, Sabine4 aut |
| 700 | 1 | a Bermisheva, Marinau University of Melbourne,Cancer Council Victoria4 aut |
| 700 | 1 | a Blomqvist, Carl4 aut |
| 700 | 1 | a Bogdanova, Natalia V4 aut |
| 700 | 1 | a Bojesen, Stig E4 aut |
| 700 | 1 | a Bonanni, Bernardo4 aut |
| 700 | 1 | a Brenner, Hermann4 aut |
| 700 | 1 | a Brüning, Thomas4 aut |
| 700 | 1 | a Buys, Saundra S4 aut |
| 700 | 1 | a Camp, Nicola J4 aut |
| 700 | 1 | a Campa, Daniele4 aut |
| 700 | 1 | a Canzian, Federico4 aut |
| 700 | 1 | a Castelao, Jose E4 aut |
| 700 | 1 | a Cessna, Melissa H4 aut |
| 700 | 1 | a Chang-Claude, Jenny4 aut |
| 700 | 1 | a Chanock, Stephen J4 aut |
| 700 | 1 | a Clarke, Christine L4 aut |
| 700 | 1 | a Conroy, Don M4 aut |
| 700 | 1 | a Couch, Fergus J4 aut |
| 700 | 1 | a Cox, Angela4 aut |
| 700 | 1 | a Cross, Simon S4 aut |
| 700 | 1 | a Czene, Kamilau Karolinska Institutet4 aut |
| 700 | 1 | a Daly, Mary B4 aut |
| 700 | 1 | a Devilee, Peter4 aut |
| 700 | 1 | a Dörk, Thilo4 aut |
| 700 | 1 | a Dwek, Miriam4 aut |
| 700 | 1 | a Eccles, Diana M4 aut |
| 700 | 1 | a Eliassen, A Heather4 aut |
| 700 | 1 | a Engel, Christoph4 aut |
| 700 | 1 | a Eriksson, Mikaelu Karolinska Institutet4 aut |
| 700 | 1 | a Evans, D Gareth4 aut |
| 700 | 1 | a Fasching, Peter A4 aut |
| 700 | 1 | a Fletcher, Olivia4 aut |
| 700 | 1 | a Flyger, Henrik4 aut |
| 700 | 1 | a Fritschi, Lin4 aut |
| 700 | 1 | a Gabrielson, Marikeu Karolinska Institutet4 aut |
| 700 | 1 | a Gago-Dominguez, Manuela4 aut |
| 700 | 1 | a García-Closas, Montserrat4 aut |
| 700 | 1 | a García-Sáenz, José A4 aut |
| 700 | 1 | a Goldberg, Mark S4 aut |
| 700 | 1 | a Guénel, Pascal4 aut |
| 700 | 1 | a Gündert, Melanie4 aut |
| 700 | 1 | a Hahnen, Eric4 aut |
| 700 | 1 | a Haiman, Christopher A4 aut |
| 700 | 1 | a Häberle, Lothar4 aut |
| 700 | 1 | a Håkansson, Niclasu Karolinska Institutet4 aut |
| 700 | 1 | a Hall, Peru Karolinska Institutet4 aut |
| 700 | 1 | a Hamann, Ute4 aut |
| 700 | 1 | a Hart, Steven N4 aut |
| 700 | 1 | a Harvie, Michelle4 aut |
| 700 | 1 | a Hillemanns, Peter4 aut |
| 700 | 1 | a Hollestelle, Antoinette4 aut |
| 700 | 1 | a Hooning, Maartje J4 aut |
| 700 | 1 | a Hoppe, Reiner4 aut |
| 700 | 1 | a Hopper, John4 aut |
| 700 | 1 | a Howell, Anthony4 aut |
| 700 | 1 | a Hunter, David J4 aut |
| 700 | 1 | a Jakubowska, Anna4 aut |
| 700 | 1 | a Janni, Wolfgang4 aut |
| 700 | 1 | a John, Esther M4 aut |
| 700 | 1 | a Jung, Audrey4 aut |
| 700 | 1 | a Kaaks, Rudolf4 aut |
| 700 | 1 | a Keeman, Renske4 aut |
| 700 | 1 | a Kitahara, Cari M4 aut |
| 700 | 1 | a Koutros, Stella4 aut |
| 700 | 1 | a Kraft, Peter4 aut |
| 700 | 1 | a Kristensen, Vessela N4 aut |
| 700 | 1 | a Kubelka-Sabit, Katerina4 aut |
| 700 | 1 | a Kurian, Allison W4 aut |
| 700 | 1 | a Lacey, James V4 aut |
| 700 | 1 | a Lambrechts, Diether4 aut |
| 700 | 1 | a Le Marchand, Loic4 aut |
| 700 | 1 | a Lindblom, Annika4 aut |
| 700 | 1 | a Loibl, Sibylle4 aut |
| 700 | 1 | a Lubiński, Jan4 aut |
| 700 | 1 | a Mannermaa, Arto4 aut |
| 700 | 1 | a Manoochehri, Mehdi4 aut |
| 700 | 1 | a Margolin, Sarau Karolinska Institutet4 aut |
| 700 | 1 | a Martinez, Maria Elena4 aut |
| 700 | 1 | a Mavroudis, Dimitrios4 aut |
| 700 | 1 | a Menon, Usha4 aut |
| 700 | 1 | a Mulligan, Anna Marie4 aut |
| 700 | 1 | a Murphy, Rachel A4 aut |
| 700 | 1 | a Collaborators, Nbcs4 aut |
| 700 | 1 | a Nevanlinna, Heli4 aut |
| 700 | 1 | a Nevelsteen, Ines4 aut |
| 700 | 1 | a Newman, William G4 aut |
| 700 | 1 | a Offit, Kenneth4 aut |
| 700 | 1 | a Olshan, Andrew F4 aut |
| 700 | 1 | a Olsson, H.u Lund University,Lunds universitet,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Biomarkörer och Epi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund Melanoma Study Group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Biomarkers and epidemiology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-hol |
| 700 | 1 | a Orr, Nick4 aut |
| 700 | 1 | a Patel, Alpa4 aut |
| 700 | 1 | a Peto, Julian4 aut |
| 700 | 1 | a Plaseska-Karanfilska, Dijana4 aut |
| 700 | 1 | a Presneau, Nadege4 aut |
| 700 | 1 | a Rack, Brigitte4 aut |
| 700 | 1 | a Radice, Paolo4 aut |
| 700 | 1 | a Rees-Punia, Erika4 aut |
| 700 | 1 | a Rennert, Gad4 aut |
| 700 | 1 | a Rennert, Hedy S4 aut |
| 700 | 1 | a Romero, Atocha4 aut |
| 700 | 1 | a Saloustros, Emmanouil4 aut |
| 700 | 1 | a Sandler, Dale P4 aut |
| 700 | 1 | a Schmidt, Marjanka K4 aut |
| 700 | 1 | a Schmutzler, Rita K4 aut |
| 700 | 1 | a Schwentner, Lukas4 aut |
| 700 | 1 | a Scott, Christopher4 aut |
| 700 | 1 | a Shah, Mitul4 aut |
| 700 | 1 | a Shu, Xiao-Ou4 aut |
| 700 | 1 | a Simard, Jacques4 aut |
| 700 | 1 | a Southey, Melissa C4 aut |
| 700 | 1 | a Stone, Jennifer4 aut |
| 700 | 1 | a Surowy, Harald4 aut |
| 700 | 1 | a Swerdlow, Anthony J4 aut |
| 700 | 1 | a Tamimi, Rulla M4 aut |
| 700 | 1 | a Tapper, William J4 aut |
| 700 | 1 | a Taylor, Jack A4 aut |
| 700 | 1 | a Terry, Mary Beth4 aut |
| 700 | 1 | a Tollenaar, Rob A E M4 aut |
| 700 | 1 | a Troester, Melissa A4 aut |
| 700 | 1 | a Truong, Thérèse4 aut |
| 700 | 1 | a Untch, Michael4 aut |
| 700 | 1 | a Vachon, Celine M4 aut |
| 700 | 1 | a Joseph, Vijai4 aut |
| 700 | 1 | a Wappenschmidt, Barbara4 aut |
| 700 | 1 | a Weinberg, Clarice R4 aut |
| 700 | 1 | a Wolk, Alicjau Uppsala universitet,Medicinsk epidemiologi,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden4 aut0 (Swepub:uu)alwol516 |
| 700 | 1 | a Yannoukakos, Drakoulis4 aut |
| 700 | 1 | a Zheng, Wei4 aut |
| 700 | 1 | a Ziogas, Argyrios4 aut |
| 700 | 1 | a Dunning, Alison M4 aut |
| 700 | 1 | a Pharoah, Paul D P4 aut |
| 700 | 1 | a Easton, Douglas F4 aut |
| 700 | 1 | a Milne, Roger L4 aut |
| 700 | 1 | a Lynch, Brigid M4 aut |
| 710 | 2 | a Karolinska Institutetb Cancer Council Victoria4 org |
| 710 | 2 | a Breast Cancer Association Consortium |
| 773 | 0 | t British Journal of Sports Medicined : BMJ Publishing Group Ltdg 56:20, s. 1157-1170q 56:20<1157-1170x 0306-3674x 1473-0480 |
| 856 | 4 | u http://dx.doi.org/10.1136/bjsports-2021-105132y FULLTEXT |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-489540 |
| 856 | 4 8 | u https://doi.org/10.1136/bjsports-2021-105132 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:150459871 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/33b1be06-6bf7-43ac-a73c-1357fab4e5bf |
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