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The impact of supra...
The impact of supraventricular ectopic complexes in different age groups and risk of recurrent atrial fibrillation after antiarrhythmic medication or catheter ablation
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- Alhede, Christina (author)
- Herlev Gentofte University Hospital, Denmark
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- Lauridsen, Trine K. (author)
- Herlev Gentofte University Hospital, Denmark
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- Johannessen, Arne (author)
- Herlev Gentofte University Hospital, Denmark
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- Dixen, Ulrik (author)
- Hvidovre University Hospital, Denmark
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- Jensen, Jan S. (author)
- Herlev Gentofte University Hospital, Denmark
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- Raatikainen, Pekka (author)
- Helsinki University Hospital, Finland
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- Hindricks, Gerhard (author)
- Leipzig University Hospital, Germany
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- Walfridsson, Håkan (author)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Kongstadf, Ole (author)
- Lund University Hospital, Sweden
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- Pehrson, Steen (author)
- Rigshosp, Denmark
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- Englund, Anders (author)
- Örebro University Hospital, Sweden
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- Hartikainen, Juha (author)
- Kupio University Hospital, Finland
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- Hansen, Peter S. (author)
- Varde Heart Centre, Denmark
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- Nielsen, Jens C. (author)
- Aarhus University Hospital, Denmark
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- Jons, Christian (author)
- Rigshosp, Denmark
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(creator_code:org_t)
- ELSEVIER IRELAND LTD, 2018
- 2018
- English.
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In: International Journal of Cardiology. - : ELSEVIER IRELAND LTD. - 0167-5273 .- 1874-1754. ; 250, s. 122-127
- Related links:
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https://helda.helsin...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Introduction: Supraventricular ectopic complexes (SVEC) are known risk factors of recurrent atrial fibrillation (AF). However, the impact of SVEC in different age groups is unknown. We aimed to investigate the risk of AF recurrence with higher SVEC burden in patients +/- 57 years, respectively, after treatment with antiarrhythmic medication (AAD) or catheter ablation (CA). Methods: In total, 260 patients with LVEF amp;gt;40% and age amp;lt;= 70 years were randomized to AAD (N = 132) or CA (N = 128) as first-line treatment for paroxysmal AF. All patients underwent 7-day Holter monitoring at baseline, and after 3, 6, 12, 18 and 24 months and were categorized according to median age +/- 57 years. We used multi-variate Cox regression analyses and we defined high SVEC burden at 3 months of follow-up as the upper 75th percentile amp;gt;195 SVEC/day. AF recurrence was defined as AF amp;gt;= 1 min, AF-related cardioversion or hospitalization. Results: Age amp;gt;57 years were significantly associated with higher AF recurrence rate after CA (58% vs 36%, p = 0.02). After CA, we observed a higher SVEC burden during follow-up in patients amp;gt;57 years which was not observed in the younger age group treatedwith CA (p = 0.006). High SVEC burden at 3 months after CA was associated with AF recurrence in older patients but not in younger patients (amp;gt;57 years: HR 3.4 [1.4-7.9], p = 0.005). We did not find any age-related differences after AAD. Conclusion: We found that younger and older patients respond differently to CA and that SVEC burden was only associated with AF recurrence in older patients. (C) 2017 Elsevier B.V. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Arrhythmia; Age; Treatment; Recurrence; Premature ectopic beats
Publication and Content Type
- ref (subject category)
- art (subject category)
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Alhede, Christin ...
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Lauridsen, Trine ...
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Johannessen, Arn ...
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Dixen, Ulrik
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Jensen, Jan S.
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Raatikainen, Pek ...
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Hindricks, Gerha ...
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Walfridsson, Håk ...
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Kongstadf, Ole
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Pehrson, Steen
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Englund, Anders
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Hartikainen, Juh ...
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Hansen, Peter S.
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Nielsen, Jens C.
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Jons, Christian
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- MEDICAL AND HEALTH SCIENCES
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Linköping University